Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK. is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1039192304
P356DOI10.1038/NRC1524
P698PubMed publication ID15630415

P2093author name stringShoukat Dedhar
Gregory Hannigan
Armelle A Troussard
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreadingQ24291182
Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.Q24291184
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinaseQ24314398
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sitesQ24318346
DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancerQ24323204
The protein kinase complement of the human genomeQ24324497
Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinaseQ24329209
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneityQ24539769
The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cellsQ24554520
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathwayQ42830760
Integrin-linked kinase (ILK) expression in human colon cancerQ43237146
Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cellsQ43539828
Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.Q43796891
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexesQ43996515
Integrin adhesion: when is a kinase a kinase?Q43996525
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.Q44101117
Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neuronsQ44299713
Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinomaQ44321854
alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cellsQ44365696
Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factorQ44696007
Regulation of tumor angiogenesis by integrin-linked kinase (ILK).Q44746334
Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transitionQ44814280
Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potencyQ45010284
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanismQ47074406
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathwaysQ47937413
ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells.Q52088055
Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinasesQ57445929
Down-Regulation of DOC-2 in Colorectal Cancer Points to Its Role as a Tumor Suppressor in This MalignancyQ57767890
Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complexQ64378764
A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migrationQ77123038
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomasQ80408118
Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinaseQ80428766
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1Q107343694
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).Q40837811
The integrin-linked kinase (ILK) suppresses anoikisQ40860408
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicityQ41067663
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progressionQ41109515
A link between cyclin A expression and adhesion-dependent cell cycle progressionQ41509705
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activityQ41715749
Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinaseQ41827565
Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edgeQ41884314
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivoQ42442207
Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluidQ42450835
Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinomaQ42459911
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathwayQ42618265
Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interactionQ24676556
The integrin-actin connection, an eternal love affairQ24676735
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interactionQ24679147
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domainQ27628157
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.Q27824819
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposisQ28189965
The role of integrin-linked kinase (ILK) in cancer progressionQ28190174
PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and SurvivalQ28208706
Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesionsQ28212649
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343Q28213632
Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migrationQ28217164
Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signalingQ28218983
Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4Q28240165
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family membersQ28250257
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cellsQ28275069
ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumourQ28282422
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugsQ28343682
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Integrin-linked kinase is a positive mediator of L6 myoblast differentiationQ28567387
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinaseQ28570031
Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelinationQ28570846
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathwaysQ28571378
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulationQ28585627
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesionsQ28589673
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growthQ28590099
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytesQ28591949
The protein kinase B/Akt signalling pathway in human malignancyQ28645742
Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinaseQ30661698
Spatial localization of mono-and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cellsQ31130958
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.Q33762935
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.Q33911629
Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent mannerQ33959947
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localizationQ34100459
Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.Q34137296
Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation.Q34153751
Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.Q34157973
Dual control of cell growth by somatomedins and platelet-derived growth factorQ34166887
ILKAP regulates ILK signaling and inhibits anchorage-independent growthQ34301995
Mechanotransduction Across the Cell Surface and Through the CytoskeletonQ34306171
Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survivalQ34337340
Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancerQ34356308
Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexesQ34429805
Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cellsQ34478047
PTEN: The down side of PI 3-kinase signalling.Q34540849
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out).Q34768669
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.Q34792468
Integrin signaling to the actin cytoskeleton.Q35547365
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.Q35725912
Integrin-linked kinase (ILK) in combination molecular targeting.Q35784993
The PINCH-ILK-parvin complexes: assembly, functions and regulation.Q35832718
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdownQ36232499
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma proteinQ36236717
Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cellsQ36254887
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/AktQ36323145
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activationQ36364880
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membraneQ36379951
Characterisation of integrin-linked kinase signalling in sporadic human colon cancerQ36649005
Integrin-linked kinase regulates endothelial cell survival and vascular development.Q37493087
Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrinsQ37597345
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesisQ39814662
Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity.Q40525063
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinaseQ40533718
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.Q40559153
Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398.Q40563572
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activationQ40657196
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.Q40674603
Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent mannerQ40766267
Integrin-linked kinase regulates chondrocyte shape and proliferationQ40771629
Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosisQ40777998
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)51-63
P577publication date2005-01-01
P1433published inNature Reviews CancerQ641657
P1476titleIntegrin-linked kinase: a cancer therapeutic target unique among its ILK.
P478volume5

Reverse relations

cites work (P2860)
Q5979775812-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer
Q3987620217-AAG, a Hsp90 inhibitor, attenuates the hypoxia-induced expression of SDF-1alpha and ILK in mouse RPE cells
Q39656305A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
Q87832682A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
Q35781567A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells
Q39148033A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells
Q28383207A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis
Q47149287ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis.
Q36969866Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis
Q41510993Activated Integrin-Linked Kinase Negatively Regulates Muscle Cell Enhancement Factor 2C in C2C12 Cells
Q36836697Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells
Q28244044Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin
Q61813975Adhesion Deregulation in Acute Myeloid Leukaemia
Q36721762Altered local and systemic immune profiles underlie lymph node metastasis in breast cancer patients.
Q28564696An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth
Q35608920Androgen receptor in laryngeal carcinoma: could there be an androgen-refractory tumor?
Q33896998Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway
Q35310168Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
Q39028687Anoikis and EMT: Lethal "Liaisons" during Cancer Progression
Q33763531Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma
Q26852158Anoikis molecular pathways and its role in cancer progression
Q34878637Anticancer actions of PPARγ ligands: Current state and future perspectives in human lung cancer
Q36241745Assembly and signaling of adhesion complexes
Q45986472Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
Q37970379Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression
Q33792600Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons
Q46066210CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling.
Q41840182COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP.
Q37631589Cell adhesion molecules: role and clinical significance in cancer
Q57073625Cell-cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis
Q37885569Centrosome clustering and chromosomal (in)stability: a matter of life and death
Q52563044Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.
Q42382167Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer
Q28553202Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells
Q99712040Comprehending Meningioma Signaling Cascades Using Multipronged Proteomics Approaches & Targeted Validation of Potential Markers
Q92648423Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity
Q42126608Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition
Q34048129Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development
Q40190677Critical involvement of ILK in TGFbeta1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system
Q37376161Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development
Q46888149Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.
Q42378361Cross-talk mechanism between endothelial cells and hepatocellular carcinoma cells via growth factors and integrin pathway promotes tumor angiogenesis and cell migration
Q39658831Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity
Q30491518Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness
Q54518183DICAM inhibits osteoclast differentiation through attenuation of the integrin αVβ3 pathway.
Q45412782DRR regulates AKT activation to drive brain cancer invasion
Q31171102Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells
Q36140879Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion
Q37137781Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality.
Q36202892Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency
Q27657269Determination of Multicomponent Protein Structures in Solution Using Global Orientation and Shape Restraints
Q54680137Differential beta-catenin expression between glottic and supraglottic laryngeal carcinoma.
Q34343134Down-regulation of uPAR and cathepsin B retards cofilin dephosphorylation.
Q46970691EGFR and beta1 integrins utilize different signaling pathways to activate Akt.
Q48230331Effect of matrix stiffness on osteoblast functionalization.
Q36774751Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells
Q35640263Elevated PI3K signaling drives multiple breast cancer subtypes
Q54197498Emodin Inhibits Migration and Invasion of Human Endometrial Stromal Cells by Facilitating the Mesenchymal-Epithelial Transition Through Targeting ILK.
Q37549516Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway
Q30564783Engineering the heart: evaluation of conductive nanomaterials for improving implant integration and cardiac function
Q40229398Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells
Q38759490Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy
Q38238991Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer
Q36857782Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis
Q47264014Estimation of pH effect on the structure and stability of kinase domain of human integrin-linked kinase
Q53299222Evaluation of thymosin β4 in the regulation of epithelial-mesenchymal transformation in urothelial carcinoma
Q41670915Exploring the Role of RGD-Recognizing Integrins in Cancer
Q39144655Expression of integrin-linked kinase in adenoid cystic carcinoma of salivary glands correlates with epithelial-mesenchymal transition markers and tumor progression
Q40120870Expression of integrin-linked kinase in the murine lens is consistent with its role in epithelial-mesenchymal transition of lens epithelial cells in vitro
Q39978242Expression of integrin-linked kinase is increased in differentiated cells
Q34253712Expression of parvin-β is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract
Q35846780FH535 inhibited metastasis and growth of pancreatic cancer cells
Q39789526Fibronectin-integrin mediated signaling in human cervical cancer cells (SiHa).
Q43154325Fish oil inhibits human lung carcinoma cell growth by suppressing integrin-linked kinase
Q37362793Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells
Q48011517Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
Q42409252Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair
Q36117925Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics
Q37406670Focal adhesion: a focal point in current cell biology and molecular medicine
Q36352100From Rapa Nui to rapamycin: targeting PI3K/Akt/mTOR for cancer therapy
Q38765612Gene set enrichment analysis and ingenuity pathway analysis of metastatic clear cell renal cell carcinoma cell line
Q38694367Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Q92764183Hypoxia-Induced Phenotypes that Mediate Tumor Heterogeneity
Q51736765ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance.
Q34292636ILK induces cardiomyogenesis in the human heart
Q34597585ILK mediates the effects of strain on intestinal epithelial wound closure
Q36403372ILK, PINCH and parvin: the tIPP of integrin signalling
Q36544158ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation
Q37352611ING4 regulates JWA in angiogenesis and their prognostic value in melanoma patients
Q33985104Identification and characterization of a novel integrin-linked kinase inhibitor
Q36202719Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival
Q37242557Identification of ILK as a novel therapeutic target for acute and chronic myeloid leukemia
Q33953601Identification of collaborative driver pathways in breast cancer
Q37272247Impact of heat-shock protein 90 on cancer metastasis
Q35754558Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model
Q36536533Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis
Q40899414In vivo gut transcriptome responses to Lactobacillus rhamnosus GG and Lactobacillus acidophilus in neonatal gnotobiotic piglets
Q37528252Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.
Q34163462Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats
Q58766018Indirect Down-regulation of Tumor-suppressive Family MicroRNAs by in Neuroblastoma
Q98195632Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons
Q33688434Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression
Q54374144Inhibition of high glucose-induced VEGF and ICAM-1 expression in human retinal pigment epithelium cells by targeting ILK with small interference RNA.
Q37330584Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis
Q34729973Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria
Q36625236Inhibitors of signal transduction protein kinases as targets for cancer therapy
Q92969956Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism
Q35807732Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network
Q37457890Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity
Q41869916Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus
Q37406751Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells
Q37688804Integrin signaling and lung cancer.
Q42826052Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation
Q28299126Integrin signalling adaptors: not only figurants in the cancer story
Q37271581Integrin signalling at a glance
Q92383113Integrin-Linked Kinase Is Involved In the Proliferation and Invasion of Esophageal Squamous Cell Carcinoma
Q38748841Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors.
Q50993502Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease.
Q36930821Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice
Q36735258Integrin-Linked Kinase: It's Role in the Vascular System
Q43786778Integrin-linked kinase (ILK) expression correlates with tumor severity in clear cell renal carcinoma
Q37825335Integrin-linked kinase 1: role in hormonal cancer progression
Q40330932Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival
Q37225450Integrin-linked kinase activity modulates the pro-metastatic behavior of ovarian cancer cells
Q53675615Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.
Q37220527Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer.
Q35950088Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase
Q91361879Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
Q82052532Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas
Q37208161Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly.
Q33533661Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration.
Q43122600Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.
Q42357572Integrin-linked kinase in ciliary Hedgehog signaling
Q28261429Integrin-linked kinase is an adaptor with essential functions during mouse development
Q37172536Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation
Q43011923Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation
Q24655829Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
Q28589224Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis
Q34283506Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor-α production via regulation of p65 serine 536 phosphorylation
Q33828741Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma
Q39942925Integrin-linked kinase regulates E-cadherin expression through PARP-1.
Q27321017Integrin-linked kinase regulates interphase and mitotic microtubule dynamics
Q40317325Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells
Q36890811Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells
Q43119912Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma
Q37878251Integrin-linked kinase: not so 'pseudo' after all.
Q38851702Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix
Q28066805Integrins in the Spotlight of Cancer
Q39939384Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation
Q35759468Integrins modulate relapse to cocaine-seeking
Q24310715Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling
Q36117238Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.
Q26798882Is there a role for epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor wild-type non-small cell lung cancer?
Q37209242JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma
Q22337328Key Regulators in Neuronal Polarity
Q39205429Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation.
Q84947040Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells
Q39628047Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase
Q39693828L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression
Q30588724LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase
Q35987858LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.
Q39709977Laminin induces matrix metalloproteinase-9 expression and activation in human cervical cancer cell line (SiHa).
Q38481151Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.
Q35238482MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis
Q36299911Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
Q21296660Matricellular proteins: a sticky affair with cancers
Q33804105Mechanisms of the epithelial-mesenchymal transition by TGF-beta
Q34210068MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression
Q38415772MicroRNAs as the fine-tuners of Src oncogenic signalling
Q59339290Microwave-induced enhancement of the dissolution rate of poorly water-soluble tibolone from poly(ethylene glycol) solid dispersions
Q40262829Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells
Q36848899Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front
Q28255061Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival
Q37306922Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation
Q51055209Molecular mechanisms involved in podocyte EMT and concomitant diabetic kidney diseases: an update.
Q37225156Molecular signatures in urologic tumors
Q52723794Multifaced Roles of the αvβ3 Integrin in Ehlers-Danlos and Arterial Tortuosity Syndromes' Dermal Fibroblasts.
Q58613172Muscarinic m2 receptor-mediated actin polymerization via PI3 kinase γ and integrin-linked kinase in gastric smooth muscle
Q35048027Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex
Q37783442New Insights into the Regulation of Ion Channels by Integrins
Q36010095New insights into epithelial-mesenchymal transition in kidney fibrosis
Q36519041New therapies for hepatocellular carcinoma.
Q58115566Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
Q34619203Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways.
Q57112652OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics
Q38974336Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors
Q37716265Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.
Q54508477Over-expression of integrin-linked kinase correlates with aberrant expression of Snail, E-cadherin and N-cadherin in oral squamous cell carcinoma: implications in tumor progression and metastasis.
Q50853594Overexpression of ILK1 in breast cancer associates with poor prognosis.
Q38400105Overexpression of integrin-linked kinase (ILK) is associated with tumor progression and an unfavorable prognosis in patients with colorectal cancer
Q39094498Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-κB pathway
Q42252800Overexpression of integrin-linked kinase promotes lung cancer cell migration and invasion via NF-κB-mediated upregulation of matrix metalloproteinase-9.
Q91698199PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis
Q38295612PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells
Q28292541PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer
Q34695847Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion
Q36421428Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation
Q54285345Periostin Enhances Migration, Invasion, and Adhesion of Human Endometrial Stromal Cells Through Integrin-Linked Kinase 1/Akt Signaling Pathway.
Q36731121Periostin Facilitates the Epithelial-Mesenchymal Transition of Endometrial Epithelial Cells through ILK-Akt Signaling Pathway
Q40040300Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro
Q28297327Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase
Q42092696Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure.
Q37216618Prospective of Ras signaling in stem cells
Q35586502Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice
Q36060746Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog
Q40527980Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity
Q34725837Proteomic analysis of chicken peripheral blood mononuclear cells after infection by Newcastle disease virus.
Q28485871Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex
Q37277114QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatmen
Q34182228Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.
Q33977140Recombinant viral capsid protein VP1 suppresses lung cancer metastasis by inhibiting COX-2/PGE2 and MIG-7.
Q94475256Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells
Q38815948Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells.
Q35761146Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells
Q34984892Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis.
Q26741077Research advances on structure and biological functions of integrins
Q38217707Research progress in signalling pathway in diabetic nephropathy
Q34806539Retracted: Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines
Q38692681Robustness of integrin signaling network
Q33977681Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.
Q44660842Role of integrin-linked kinase in osteosarcoma progression.
Q38686618Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells
Q28572867Role of the integrin-linked kinase (ILK) in determining neuronal polarity
Q39400819Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).
Q37679943SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome
Q33222107SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity
Q35930608Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Q37147752Selective anticancer strategies via intervention of the death pathways relevant to cell transformation
Q60601167Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration
Q36749420Serum concentration of integrin-linked kinase in malignant pleural mesothelioma and after asbestos exposure
Q45013092Serum integrin-linked kinase (sILK) concentration and survival in non-small cell lung cancer: a pilot study.
Q35213019Signaling mechanisms of the epithelial-mesenchymal transition
Q36627998Signaling networks in neuronal polarization.
Q33916456Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy
Q39298534Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1).
Q28546518Simulation predicts IGFBP2-HIF1α interaction drives glioblastoma growth
Q30440581Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3
Q37932559Solid dispersions, part II: new strategies in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs
Q64100009Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
Q36914640Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance.
Q95322301Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia
Q46171254Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain
Q27658441Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase
Q24312707Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase
Q52626789Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1.
Q37681488Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients
Q33718142Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance
Q41866389Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure
Q34230960Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival
Q37691830Targeting anoikis resistance in prostate cancer metastasis
Q47071450The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link
Q27646573The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions
Q39046463The cancer cell adhesion resistome: mechanisms, targeting and translational approaches
Q36717612The extracellular matrix as an adhesion checkpoint for mammary epithelial function
Q34118683The function of integrin-linked kinase in normal and activated stellate cells: implications for fibrogenesis in wound healing
Q37764250The importance of endothelin axis in initiation, progression, and therapy of ovarian cancer
Q39586214The importance of integrin-linked kinase in the regulation of bladder cancer invasion
Q36969635The inhibitory effect of ellagic Acid on cell growth of ovarian carcinoma cells
Q34031745The motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans
Q26825105The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration
Q37118131The p21-activated kinase is required for neuronal migration in the cerebral cortex.
Q36325617The parvins
Q37040558The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells
Q36219713The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck.
Q26827638The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy
Q33489630The small molecule inhibitor QLT0267 Radiosensitizes squamous cell carcinoma cells of the head and neck
Q24324678The structural basis of integrin-linked kinase-PINCH interactions
Q36274952The survival kinases Akt and Pim as potential pharmacological targets
Q97525008Therapeutic effect of integrin-linked kinase gene-modified bone marrow-derived mesenchymal stem cells for streptozotocin-induced diabetic cystopathy in a rat model
Q37628723There's something about ILK.
Q54573803Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase.
Q54558264Thymosin β4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation.
Q38752916Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells
Q42669981Transcription factors and stress response gene alterations in human keratinocytes following Solar Simulated Ultra Violet Radiation.
Q43187744Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma
Q22254808Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1
Q36977706Understanding h-prune biology in the fight against cancer.
Q39807837Up-regulation of integrin expression in lung adenocarcinoma cells caused by bacterial infection: in vitro study
Q36790876Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK)
Q37542907Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.
Q64890764Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism.
Q53030618[Butterfly effect and cancer: how a mechanical pressure induced in vivo leads to tumorigenesis in neighboring healthy cells].
Q39608009c-Jun N-terminal kinase is involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells
Q35312201mda-9/Syntenin protein positively regulates the activation of Akt protein by facilitating integrin-linked kinase adaptor function during adhesion to type I collagen
Q28564568tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling
Q41538152β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction.
Q34011023β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells

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