ILK mediates the effects of strain on intestinal epithelial wound closure

scientific article

ILK mediates the effects of strain on intestinal epithelial wound closure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00273.2010
P932PMC publication ID3043633
P698PubMed publication ID21084641
P5875ResearchGate publication ID47811971

P2093author name stringMarc D Basson
Lisi Yuan
Matthew A Sanders
P2860cites workOsteopontin stimulates vascular smooth muscle cell migration by inducing FAK phosphorylation and ILK dephosphorylationQ79871211
Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeatsQ22010842
ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signalingQ23924060
Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICAQ24292262
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinaseQ24314398
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interactionQ24679147
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
The structural basis of localization and signaling by the focal adhesion targeting domainQ27638962
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343Q28213632
Integrin-linked kinase is an adaptor with essential functions during mouse developmentQ28261429
One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23Q28294341
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cellsQ28344025
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinaseQ28570031
Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protectionQ28571389
Integrin-linked kinase in the vascular smooth muscle cell response to injuryQ28581550
Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complexQ28583390
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulationQ28585627
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous systemQ28587844
Integrin-linked kinase is required for epidermal and hair follicle morphogenesisQ30480583
Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinaseQ30661698
Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2Q33200951
Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factorQ33229227
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!Q33668166
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.Q33762935
Phosphoinositide 3-kinase signalling pathwaysQ33940898
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localizationQ34100459
Review of postoperative ileusQ34470196
Integrin-linked kinase: a cancer therapeutic target unique among its ILK.Q35998768
Cellular and molecular mechanisms of gastrointestinal ulcer healingQ36268032
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membraneQ36379951
ILK, PINCH and parvin: the tIPP of integrin signallingQ36403372
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damageQ36491774
Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermisQ36536533
Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migrationQ36825525
Evidence for the involvement of infectious agents in the pathogenesis of Crohn's diseaseQ37073806
Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cellsQ37169951
Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migrationQ37216047
Integrin-linked kinase--essential roles in physiology and cancer biology.Q37272385
Colonic motility in humans--a growing understandingQ37363560
Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cellsQ37677429
Epithelia under metabolic stress perceive commensal bacteria as a threatQ38722151
Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectinQ39889567
Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activityQ39903260
Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathwayQ39910462
Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayersQ39938136
Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3beta in endothelial cellsQ40135983
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cellsQ40184472
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activationQ40657196
Integrin-linked kinase regulates chondrocyte shape and proliferationQ40771629
Normal physiology of small intestinal motility.Q40784009
Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayersQ41181973
In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cellsQ41372887
Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failureQ41866389
Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathwayQ42138548
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturationQ42164315
Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanismQ42926530
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexesQ43996515
Altered small bowel motility in irritable bowel syndrome is correlated with symptoms.Q44194795
Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT.Q44680969
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
Quantitative analysis of peristalsis in the guinea-pig small intestine using spatio-temporal mapsQ46276773
Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.Q46713928
Striated brush border of intestinal absorptive epithelial cells: stereological studies on microvillous morphology in different adaptive statesQ48890674
Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.Q51486103
Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells.Q53641500
Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.Q53675615
Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitroQ68041338
Quantitative assessment of villous motilityQ69774233
Matrix-specific FAK and MAPK reorganization during Caco-2 cell motilityQ73131906
Human caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent mannerQ73907326
Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsisQ74096434
The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependentQ79214408
Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic miceQ79334337
FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathwayQ79818499
P433issue2
P304page(s)C356-67
P577publication date2010-11-17
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleILK mediates the effects of strain on intestinal epithelial wound closure
P478volume300

Reverse relations

cites work (P2860)
Q54195613A novel role for integrin-linked kinase in periodic mechanical stress-mediated ERK1/2 mitogenic signaling in rat chondrocytes.
Q38886083Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion
Q33701592Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism
Q93118372Emerging regulators of vascular smooth muscle cell migration
Q90402561ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process
Q51087956Integrin linked kinase regulates syncytialization of BeWo trophoblast cells.
Q36429803Intestinal mucosal atrophy and adaptation
Q38619878Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome
Q35543310Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells

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