| scholarly article | Q13442814 |
| P2093 | author name string | S Dedhar | |
| V Gray | |||
| S Persad | |||
| J Sanghera | |||
| M Delcommenne | |||
| A Troussard | |||
| S Attwell | |||
| P2860 | cites work | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 |
| Direct control of the Forkhead transcription factor AFX by protein kinase B | Q22009452 | ||
| Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats | Q22010842 | ||
| TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
| Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase | Q24314398 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells | Q24554520 | ||
| Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway | Q24653458 | ||
| Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways | Q24655497 | ||
| Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase | Q24682825 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| PTEN1 is frequently mutated in primary endometrial carcinomas | Q28250937 | ||
| Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt | Q28255373 | ||
| MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines | Q28256046 | ||
| Regulation of cell death protease caspase-9 by phosphorylation | Q28288607 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways | Q28571378 | ||
| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway | Q28588309 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation | Q30452661 | ||
| PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. | Q33860504 | ||
| Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner | Q33959947 | ||
| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 | ||
| The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. | Q35250021 | ||
| Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin | Q36235456 | ||
| Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways | Q36256326 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity | Q41067663 | ||
| Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression | Q41109515 | ||
| Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets | Q41198067 | ||
| Mechanisms and consequences of activation of protein kinase B/Akt | Q41751003 | ||
| Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway | Q42618265 | ||
| Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. | Q42815905 | ||
| Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 | ||
| PTEN gene mutations are seen in high-grade but not in low-grade gliomas. | Q44846579 | ||
| Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. | Q45029660 | ||
| Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers | Q48464018 | ||
| PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. | Q55478126 | ||
| Frequent inactivation of PTEN/MMAC1 in primary prostate cancer | Q57240096 | ||
| Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies | Q73722520 | ||
| Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome | Q73883821 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | prostate cancer | Q181257 |
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 3207-12 | |
| P577 | publication date | 2000-03-28 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells | |
| P478 | volume | 97 |
| Q28751755 | "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response |
| Q36334415 | 2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis |
| Q40455972 | 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. |
| Q34771742 | 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management |
| Q24291182 | A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading |
| Q24603024 | ARK5 is a tumor invasion-associated factor downstream of Akt signaling |
| Q47200013 | Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas |
| Q92069609 | Akt modes of stem cell regulation: more than meets the eye? |
| Q40598904 | Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells |
| Q28215553 | Anoikis mechanisms |
| Q35956150 | Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells |
| Q35603699 | Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo |
| Q47106351 | Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma |
| Q42100954 | Beta1-integrin signaling is essential for lens fiber survival |
| Q38237431 | Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression |
| Q39365401 | Cell Cycle Control by PTEN. |
| Q28138260 | Cell-substrate interactions and signaling through ILK |
| Q54557709 | Cellular repressor of E1A-stimulated genes regulates vascular endothelial cell migration by the ILK/AKT/mTOR/VEGF(165) signaling pathway. |
| Q37118092 | Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis. |
| Q37376161 | Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development |
| Q40415917 | Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation |
| Q28360348 | Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells |
| Q28581884 | Dp71f modulates GSK3-beta recruitment to the beta1-integrin adhesion complex |
| Q40850887 | Effect of PTEN Gene Mutations and Environmental Risk Factors on the Progression and Prognosis of Bladder Cancer. |
| Q36121689 | Evidence for PTEN-independent Akt activation and Akt-independent p27(Kip1) expression in advanced bladder cancer |
| Q36987424 | Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance. |
| Q34253712 | Expression of parvin-β is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract |
| Q37560428 | FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants |
| Q34042356 | Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells |
| Q38441711 | Gene expression, signal transduction pathways and functional networks associated with growth of sporadic vestibular schwannomas |
| Q35238980 | Genistein exerts anti-leukemic effects on genetically different acute myeloid leukemia cell lines by inhibiting protein synthesis and cell proliferation while inducing apoptosis - molecular insights from an iTRAQ™ quantitative proteomics study. |
| Q44930591 | Hepatocyte survival depends on beta1-integrin-mediated attachment of hepatocytes to hepatic extracellular matrix |
| Q38739650 | ILK and cytoskeletal architecture: an important determinant of AQP2 recycling and subsequent entry into the exocytotic pathway |
| Q34597585 | ILK mediates the effects of strain on intestinal epithelial wound closure |
| Q33985104 | Identification and characterization of a novel integrin-linked kinase inhibitor |
| Q36178164 | Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer |
| Q24795806 | Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer |
| Q34137296 | Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. |
| Q34145575 | Inhibition of protein kinase B/Akt. implications for cancer therapy |
| Q33644080 | Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target |
| Q92969956 | Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism |
| Q33762935 | Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. |
| Q33848813 | Integrin involvement in freeze resistance of androgen-insensitive prostate cancer |
| Q37406751 | Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells |
| Q37592138 | Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle |
| Q92383113 | Integrin-Linked Kinase Is Involved In the Proliferation and Invasion of Esophageal Squamous Cell Carcinoma |
| Q50993502 | Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease. |
| Q36735258 | Integrin-Linked Kinase: It's Role in the Vascular System |
| Q42624386 | Integrin-dependent Akt1 activation regulates PGC-1 expression and fatty acid oxidation |
| Q40500279 | Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8. |
| Q34429805 | Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes |
| Q43786778 | Integrin-linked kinase (ILK) expression correlates with tumor severity in clear cell renal carcinoma |
| Q37825335 | Integrin-linked kinase 1: role in hormonal cancer progression |
| Q36435777 | Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models |
| Q37225025 | Integrin-linked kinase can facilitate syncytialization and hormonal differentiation of the human trophoblast-derived BeWo cell line |
| Q35950088 | Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase |
| Q31010256 | Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells |
| Q42025988 | Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death. |
| Q38268065 | Integrin-linked kinase in gastric cancer cell attachment, invasion and tumor growth |
| Q40324201 | Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells. |
| Q30480583 | Integrin-linked kinase is required for epidermal and hair follicle morphogenesis |
| Q28570846 | Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination |
| Q28589224 | Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis |
| Q33828741 | Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma |
| Q37493087 | Integrin-linked kinase regulates endothelial cell survival and vascular development. |
| Q40766267 | Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner |
| Q39600634 | Integrin-linked kinase regulates melanoma angiogenesis by activating NF-κB/interleukin-6 signaling pathway. |
| Q37018280 | Integrin-linked kinase regulates smooth muscle differentiation marker gene expression in airway tissue. |
| Q36491774 | Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage |
| Q42850406 | Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart |
| Q34792920 | Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties |
| Q37878251 | Integrin-linked kinase: not so 'pseudo' after all. |
| Q37209242 | JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma |
| Q37002952 | Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly |
| Q89893362 | Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition |
| Q34186534 | Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway |
| Q35095228 | Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells |
| Q35217372 | Mechanical stimuli and IL-13 interact at integrin adhesion complexes to regulate expression of smooth muscle myosin heavy chain in airway smooth muscle tissue |
| Q24673182 | Mechanotransduction in skeletal muscle |
| Q57053009 | Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance |
| Q42069325 | Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via β-catenin upregulation |
| Q24291184 | Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. |
| Q35016166 | Modulation of integrin-linked kinase (ILK) expression in human oesophageal squamous cell carcinoma cell lines by the EGF and TGFbeta1 growth factors |
| Q38886538 | Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. |
| Q40694165 | Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. |
| Q38974336 | Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors |
| Q37716265 | Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption. |
| Q55404029 | Overexpressing TPTE2 (TPIP), a homolog of the human tumor suppressor gene PTEN, rescues the abnormal phenotype of the PTEN-/- mutant. |
| Q42252800 | Overexpression of integrin-linked kinase promotes lung cancer cell migration and invasion via NF-κB-mediated upregulation of matrix metalloproteinase-9. |
| Q40415899 | PKB mediates c-erbB2-induced epithelial beta1 integrin conformational inactivation through Rho-independent F-actin rearrangements |
| Q37378282 | PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells. |
| Q28292541 | PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer |
| Q24801835 | PTEN deficiency: a role in mammary carcinogenesis |
| Q43701623 | PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression |
| Q37012318 | Particularly interesting cysteine- and histidine-rich protein in cardiac development and remodeling |
| Q90031702 | Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt |
| Q34316184 | Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis. |
| Q27027815 | Posttranslational regulation of Akt in human cancer |
| Q43680908 | Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance |
| Q31059291 | Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1. |
| Q35586502 | Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice |
| Q37277114 | QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatmen |
| Q35628583 | RNA silencing of integrin-linked kinase increases the sensitivity of the A549 lung cancer cell line to cisplatin and promotes its apoptosis |
| Q34182228 | Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival. |
| Q28591949 | Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes |
| Q36439912 | Regulators of gene expression as biomarkers for prostate cancer |
| Q36218365 | Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway |
| Q34171365 | Retracted: 3, 3'-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process |
| Q34806539 | Retracted: Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines |
| Q39700543 | Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. |
| Q34193741 | Role of AKT signaling in DNA repair and clinical response to cancer therapy |
| Q39068047 | Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion. |
| Q28564942 | Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth |
| Q41882825 | SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling |
| Q61808060 | Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer |
| Q33763551 | Significance of talin in cancer progression and metastasis |
| Q37071708 | Silencing of ILK attenuates the abnormal proliferation and migration of human Tenon's capsule fibroblasts induced by TGF-β2. |
| Q34430583 | Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 |
| Q37002380 | Survival of monocytes and macrophages and their role in health and disease |
| Q41866389 | Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure |
| Q89973548 | Targeting AKT/PKB to improve treatment outcomes for solid tumors |
| Q30374421 | The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation |
| Q39586214 | The importance of integrin-linked kinase in the regulation of bladder cancer invasion |
| Q33906083 | The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer. |
| Q36745379 | The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer |
| Q44868984 | The rapid onset of hyperglycaemia in ZDF rats was associated with a widespread alteration of metabolic proteins implicated in glucose metabolism in the heart. |
| Q40526832 | The regulation of integrin-linked kinase in human platelets: evidence for involvement in the regulation of integrin alpha 2 beta 1. |
| Q36274952 | The survival kinases Akt and Pim as potential pharmacological targets |
| Q36364880 | Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation |
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