SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling

scientific article published on 5 November 2008

SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M808285200
P932PMC publication ID2613608
P698PubMed publication ID18990699

P2093author name stringJing Nie
E Helene Sage
P2860cites workFunctional interaction between peroxisome proliferator-activated receptor gamma and beta-cateninQ38408437
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinasesQ40184809
SPARC represses E-cadherin and induces mesenchymal transition during melanoma developmentQ40248571
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitroQ40307786
Changes in integrin expression during adipocyte differentiationQ40375216
Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis.Q40638066
Osteonectin-Null Mutation Compromises Osteoblast Formation, Maturation, and SurvivalQ40647978
The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinaseQ41889041
Expression and purification of recombinant human SPARC produced by baculovirusQ42055562
Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interfaceQ42492949
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Differentiation-dependent expression of laminin-8 (alpha 4 beta 1 gamma 1) mRNAs in mouse 3T3-L1 adipocytesQ42833926
Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cellsQ43539828
The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease.Q43668487
SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strengthQ44465718
Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitroQ44914125
Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsuleQ44915224
Understanding adipocyte differentiationQ46119331
Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouseQ46477839
Functional analysis of the matricellular protein SPARC with novel monoclonal antibodiesQ47585053
SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cellsQ48364943
Extracellular matrix substrata alter adipocyte yield and lipogenesis in primary cultures of stromal-vascular cells from human adipose.Q51722962
SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.Q52536817
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.Q54611050
Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and MyogenesisQ57363725
Canonical Wnt signaling in osteoblasts is required for osteoclast differentiationQ79872865
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gammaQ79918319
Inhibition of adipogenesis by Wnt signalingQ22254771
The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptorsQ24563124
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cellsQ28276215
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cellsQ28344025
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
APC-dependent suppression of colon carcinogenesis by PPARgammaQ28506424
Mitotic clonal expansion: a synchronous process required for adipogenesisQ28588756
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionQ31462537
SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activityQ33222107
Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytesQ33319636
IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cellsQ33347082
Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.Q33688041
Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiationQ33903282
Molecular regulation of adipogenesisQ34059685
SPARC, a matricellular protein: at the crossroads of cell-matrix communicationQ34164765
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-AQ34331369
Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms.Q34413514
SPARC-null mice exhibit increased adiposity without significant differences in overall body weightQ35022737
Runx2/Cbfa1: A Multifunctional Regulator of Bone FormationQ35552258
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.Q35725912
Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implicationsQ35771868
Laminin functions in tissue morphogenesis.Q35912792
Regulation of PPARgamma activity during adipogenesisQ36042255
PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptorsQ36234340
Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiationQ36324592
Laminin polymerization induces a receptor-cytoskeleton networkQ36342173
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activationQ36364880
A Wnt canon orchestrating osteoblastogenesisQ36391330
Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferationQ36872312
Osteopenia and decreased bone formation in osteonectin-deficient miceQ37176145
The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity.Q38302172
Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cellsQ38331308
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectadipogenesisQ2824461
P304page(s)1279-1290
P577publication date2008-11-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleSPARC inhibits adipogenesis by its enhancement of beta-catenin signaling
P478volume284

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cites work (P2860)
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Q36412223Association of serum SPARC level with severity of coronary artery lesion in type 2 diabetic patients with coronary heart disease
Q83631277Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions
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Q27309073SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane
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