SPARC functions as an inhibitor of adipogenesis

scientific article published on 2 October 2009

SPARC functions as an inhibitor of adipogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12079-009-0064-4
P932PMC publication ID2778584
P698PubMed publication ID19798596
P5875ResearchGate publication ID225749184

P2093author name stringJing Nie
E Helene Sage
P2860cites workInhibition of adipogenesis by Wnt signalingQ22254771
The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptorsQ24563124
SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrixQ24679549
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytesQ24791488
Structural basis of sequence-specific collagen recognition by SPARCQ27652906
Type VI collagen anchors endothelial basement membranes by interacting with type IV collagenQ28251550
The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IVQ28289732
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiationQ28357136
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
Modulation of collagen fibrillogenesis by tenascin-X and type VI collagenQ28505532
APC-dependent suppression of colon carcinogenesis by PPARgammaQ28506424
The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult miceQ28508070
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genesQ29618442
SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activityQ33222107
IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cellsQ33347082
Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytesQ33642552
Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.Q33688041
Molecular regulation of adipogenesisQ34059685
Matricellular proteins: extracellular modulators of cell functionQ34149511
Reversal of obesity by targeted ablation of adipose tissueQ34319543
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-AQ34331369
Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient miceQ34346225
Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms.Q34413514
A pericellular collagenase directs the 3-dimensional development of white adipose tissueQ34522343
Angiogenesis modulates adipogenesis and obesityQ34677131
SPARC-null mice exhibit increased adiposity without significant differences in overall body weightQ35022737
Adipose tissue angiogenesisQ35698318
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.Q35725912
De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factorQ35788885
Regulation of PPARgamma activity during adipogenesisQ36042255
SPARC is a source of copper-binding peptides that stimulate angiogenesisQ36234286
PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptorsQ36234340
Laminin polymerization induces a receptor-cytoskeleton networkQ36342173
A Wnt canon orchestrating osteoblastogenesisQ36391330
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.Q37110569
Osteopenia and decreased bone formation in osteonectin-deficient miceQ37176145
Adipogenesis and WNT signallingQ37325263
The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity.Q38302172
Functional interaction between peroxisome proliferator-activated receptor gamma and beta-cateninQ38408437
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinasesQ40184809
SPARC represses E-cadherin and induces mesenchymal transition during melanoma developmentQ40248571
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitroQ40307786
Changes in integrin expression during adipocyte differentiationQ40375216
Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis.Q40638066
Osteonectin-Null Mutation Compromises Osteoblast Formation, Maturation, and SurvivalQ40647978
Regulation of angiogenesis by SPARC and angiostatin: implications for tumor cell biologyQ41084437
White fat progenitor cells reside in the adipose vasculature.Q41145314
SPARC inhibits adipogenesis by its enhancement of beta-catenin signalingQ41882825
The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinaseQ41889041
Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryosQ42435445
Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo AdipogenesisQ42574886
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia.Q42833163
Regulation of fibronectin, integrin and cytoskeleton expression in differentiating adipocytes: inhibition by extracellular matrix and polylysineQ42834581
The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease.Q43668487
SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteinsQ43804262
SPARC-null mice exhibit accelerated cutaneous wound closureQ43826818
Increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges in SPARC-null miceQ43919367
SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strengthQ44465718
Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitroQ44914125
Understanding adipocyte differentiationQ46119331
Wnt10b inhibits development of white and brown adipose tissuesQ47364038
SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cellsQ48364943
Extracellular matrix substrata alter adipocyte yield and lipogenesis in primary cultures of stromal-vascular cells from human adipose.Q51722962
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.Q54611050
Collagen VI deficiency affects the organization of fibronectin in the extracellular matrix of cultured fibroblastsQ57006982
Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectivesQ75302855
Canonical Wnt signaling in osteoblasts is required for osteoclast differentiationQ79872865
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gammaQ79918319
Conditional deletion of beta-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometriumQ81417028
A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networksQ81514904
P433issue3-4
P921main subjectadipogenesisQ2824461
P304page(s)247-254
P577publication date2009-10-02
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titleSPARC functions as an inhibitor of adipogenesis
P478volume3

Reverse relations

cites work (P2860)
Q34547034Canonical wnt signaling regulates extracellular matrix expression in the trabecular meshwork
Q41490210Genetics of body fat mass and related traits in a pig population selected for leanness
Q50859770Healthy and tumoral tissue resistivity in wild-type and sparc-/- animal models.
Q37925022Matricellular proteins: new molecular targets to prevent heart failure
Q64898440MicroRNA and Human Bone Health.
Q36719096Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis.
Q27305401Putative regulatory factors associated with intramuscular fat content
Q91597546Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC
Q34261684Retracted: SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
Q35233858Revisiting the matricellular concept
Q37687199Roles of SPARC in urothelial carcinogenesis, progression and metastasis
Q39521848SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.
Q100694445SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells
Q42709950The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling

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