| scholarly article | Q13442814 |
| P2093 | author name string | N Nakamura | |
| T M Roberts | |||
| S Ramaswamy | |||
| S Perera | |||
| D B Batt | |||
| F Vazquez | |||
| W R Sellers | |||
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily | Q24294399 | ||
| Mechanism of activation of protein kinase B by insulin and IGF-1 | Q24309528 | ||
| Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. | Q48544624 | ||
| Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation | Q48555134 | ||
| Role of auxilin in uncoating clathrin-coated vesicles | Q50337340 | ||
| PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. | Q55478126 | ||
| Frequent inactivation of PTEN/MMAC1 in primary prostate cancer | Q57240096 | ||
| p70s6k function is essential for G1 progression | Q59054463 | ||
| Loss of the chromosomal region 10q23-25 in prostate cancer | Q71804687 | ||
| Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies | Q73722520 | ||
| A matter of life and cell death | Q77164675 | ||
| TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases | Q24323070 | ||
| Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA | Q24568308 | ||
| High-efficiency transformation of mammalian cells by plasmid DNA | Q27860469 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| PTEN1 is frequently mutated in primary endometrial carcinomas | Q28250937 | ||
| Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt | Q28255373 | ||
| MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines | Q28256046 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap | Q29620550 | ||
| 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway | Q29620730 | ||
| Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. | Q34250223 | ||
| Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. | Q34313328 | ||
| From form to function: signaling by protein tyrosine phosphatases. | Q34405391 | ||
| Translation control: connecting mitogens and the ribosome | Q34464205 | ||
| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 | ||
| Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth | Q35187190 | ||
| Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin | Q36235456 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation | Q39576120 | ||
| The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells | Q40993616 | ||
| Tumour suppression by the human von Hippel-Lindau gene product | Q41320477 | ||
| Mechanisms and consequences of activation of protein kinase B/Akt | Q41751003 | ||
| Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. | Q42815905 | ||
| PTEN: sometimes taking it off can be better than putting it on. | Q43104730 | ||
| PTEN gene mutations are seen in high-grade but not in low-grade gliomas. | Q44846579 | ||
| Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. | Q45029660 | ||
| Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation | Q45345194 | ||
| The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1. | Q48463636 | ||
| Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers | Q48464018 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2110-5 | |
| P577 | publication date | 1999-03-02 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway | |
| P478 | volume | 96 |
| Q33965618 | 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells |
| Q90146216 | A Systematic Review and Bioinformatics Study on Genes and micro-RNAs Involving the Transformation of Endometriosis into Ovarian Cancer |
| Q44714283 | A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells |
| Q41062747 | A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. |
| Q48222748 | A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma |
| Q33929512 | A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. |
| Q30749973 | A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens |
| Q40556578 | A new human cell line, PDSS-26, from poorly differentiated synovial sarcoma, with unique chromosomal anomalies |
| Q34236641 | A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis |
| Q37612660 | A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. |
| Q36836915 | A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy |
| Q37432527 | A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma |
| Q28305284 | A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. |
| Q40184782 | A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth |
| Q39171858 | AKT primes snail-induced EMT concomitantly with the collective migration of squamous cell carcinoma cells |
| Q89982718 | AKT regulates mitotic progression of mammalian cells by phosphorylating MASTL leading to PP2A inactivation |
| Q24540534 | AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. |
| Q35009571 | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling |
| Q42496198 | Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes |
| Q34013783 | Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase |
| Q36283583 | Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein |
| Q37410694 | Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism |
| Q35034550 | Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer |
| Q36313185 | Akt-regulated pathways in prostate cancer |
| Q28487802 | Akt1 enhances CA916798 expression through mTOR pathway |
| Q33740171 | Allele-specific tumor spectrum in pten knockin mice |
| Q40836678 | Alternative splicing of the human PTEN/MMAC1/TEP1 gene |
| Q30453740 | Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation |
| Q37430995 | An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation. |
| Q38314871 | Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase |
| Q73693654 | Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells |
| Q41928807 | BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation |
| Q44350476 | BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels |
| Q43700536 | Biochemical differences between SUDHL-1 and KARPAS 299 cells derived from t(2;5)-positive anaplastic large cell lymphoma are responsible for the different sensitivity to the antiproliferative effect of p27(Kip1). |
| Q39890810 | Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells |
| Q34321332 | Bisperoxovanadium compounds are potent PTEN inhibitors. |
| Q37322052 | Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis |
| Q33652855 | Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells |
| Q38519881 | Broad-spectrum antiviral agents |
| Q38893170 | CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro. |
| Q39431526 | CRM1 Inhibitors for Antiviral Therapy |
| Q24295164 | Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function |
| Q39365401 | Cell Cycle Control by PTEN. |
| Q40913396 | Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. |
| Q99591000 | Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research |
| Q36447008 | Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer |
| Q42650079 | Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers |
| Q92756232 | Compound C Inhibits B16-F1 Tumor Growth in a Syngeneic Mouse Model Via the Blockage of Cell Cycle Progression and Angiogenesis |
| Q41266999 | Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes |
| Q37479076 | Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer |
| Q33625447 | Contribution of tumor heterogeneity in a new animal model of CNS tumors |
| Q24537205 | Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors |
| Q59813350 | Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport |
| Q34015819 | Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development. |
| Q36255950 | Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway |
| Q36691800 | DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells |
| Q24550768 | Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation |
| Q90216237 | Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2 |
| Q36943802 | Degradation of Akt using protein-catalyzed capture agents. |
| Q47198022 | Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease |
| Q34104238 | Developmental mechanisms in the pathogenesis of neurodegenerative diseases |
| Q33481999 | Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes |
| Q36678446 | Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain |
| Q40802036 | Disruption of Akt kinase activation is important for immunosuppression induced by measles virus |
| Q44043150 | Dissection of angiogenic signaling in zebrafish using a chemical genetic approach |
| Q48148271 | Dnd1-mediated epigenetic control of teratoma formation in mouse |
| Q39639135 | Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus |
| Q36677595 | Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression |
| Q41560440 | Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system |
| Q39597035 | E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. |
| Q92408771 | EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways |
| Q34568941 | Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma |
| Q27003273 | Endometriosis and ovarian cancer: links, risks, and challenges faced |
| Q40509977 | Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalization in endometrial cancer cells |
| Q34561698 | Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway |
| Q34280493 | Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis |
| Q39710961 | Essential role of PI3-kinase pathway in p53-mediated transcription: Implications in cancer chemotherapy |
| Q36094983 | Establishment of oocyte population in the fetal ovary: primordial germ cell proliferation and oocyte programmed cell death |
| Q22253866 | Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 |
| Q77879703 | Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma |
| Q35095146 | Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells |
| Q91583393 | FBXO22 degrades nuclear PTEN to promote tumorigenesis |
| Q37706176 | Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells |
| Q37628912 | Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival. |
| Q50028326 | Fine tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation |
| Q33761221 | Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth |
| Q39457088 | Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. |
| Q39906248 | FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment |
| Q35842249 | Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas |
| Q34194118 | Functional analysis of the protein phosphatase activity of PTEN |
| Q47073902 | Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis |
| Q52642348 | Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. |
| Q35213246 | Gene therapy for ovarian cancer: progress and potential |
| Q58546816 | Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate |
| Q35494003 | Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response |
| Q50613740 | Germline activating AKT3 mutation associated with megalencephaly, polymicrogyria, epilepsy and hypoglycemia. |
| Q34423421 | Glioma cell growth inhibition following photochemical internalization enhanced non-viral PTEN gene transfection |
| Q28239503 | Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma |
| Q33560795 | Growth suppression of human lung cancer cells and implanted tumors by adenovirus-mediated transfer of the PTEN gene |
| Q44450066 | HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. |
| Q36419236 | Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition |
| Q36838764 | Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling |
| Q37984841 | HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis |
| Q42427997 | Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity |
| Q47118787 | Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle |
| Q34177562 | IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. |
| Q37081966 | Identification of nuclear export inhibitors with potent anticancer activity in vivo |
| Q28646919 | Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway |
| Q37623153 | Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine. |
| Q39262779 | Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses |
| Q100425524 | Immunotherapy for Metastatic Prostate Cancer: Current and Emerging Treatment Options |
| Q35806390 | In vitro and in vivo model systems used in prostate cancer research |
| Q44524425 | Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells |
| Q50752792 | Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma. |
| Q40877541 | Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression |
| Q35379204 | Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress |
| Q52727111 | Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells. |
| Q40896708 | Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene |
| Q34766464 | Inhibition of U6 snRNA Transcription by PTEN. |
| Q40841362 | Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells |
| Q28344025 | Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells |
| Q40615155 | Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias |
| Q36764258 | Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP) |
| Q64965692 | Interleukin 15 concentrations in follicular fluid and their effect on oocyte maturation in subfertile women undergoing intracytoplasmic sperm injection. |
| Q39653324 | KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro |
| Q24307898 | Kinetic mechanism of AKT/PKB enzyme family |
| Q34952741 | LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway |
| Q37718451 | LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway |
| Q38927489 | LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation |
| Q34441337 | Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. |
| Q44645813 | Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells |
| Q39273308 | Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity |
| Q35096682 | Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial |
| Q36194074 | Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2 |
| Q24797910 | Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor |
| Q55216568 | Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 |
| Q26751659 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours |
| Q34293370 | Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. |
| Q28538690 | MicroRNA-147 induces a mesenchymal-to-epithelial transition (MET) and reverses EGFR inhibitor resistance |
| Q39637411 | MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells |
| Q39433270 | MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact |
| Q46396119 | Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN. |
| Q57112111 | Molecular Subtypes of Prostate Cancer |
| Q35011121 | Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate |
| Q37138629 | Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects |
| Q37480806 | Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis |
| Q38895958 | Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity |
| Q35935658 | Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension |
| Q39387883 | Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma |
| Q36288315 | Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. |
| Q38453169 | Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53 |
| Q43167318 | Novel antioxidant technology for prostate cancer chemoprevention and treatment |
| Q55212155 | Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. |
| Q42076186 | Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation |
| Q35633427 | Nuclear transport and cancer: from mechanism to intervention |
| Q47217421 | Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase |
| Q38714699 | Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. |
| Q36937029 | Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells |
| Q37708804 | Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer |
| Q35172929 | Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1. |
| Q37645709 | Ovarian cancer in endometriosis: clinical and molecular aspects |
| Q35756547 | Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity |
| Q37122943 | PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2 |
| Q40355706 | PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis |
| Q26862544 | PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms |
| Q40923110 | PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs |
| Q38872254 | PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. |
| Q28512796 | PPARδ regulates satellite cell proliferation and skeletal muscle regeneration |
| Q36878777 | PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathways |
| Q47435142 | PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer. |
| Q30475282 | PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse |
| Q35282160 | PTEN controls tumor-induced angiogenesis |
| Q27852528 | PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation |
| Q94325481 | PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma |
| Q33765703 | PTEN gene and integrin signaling in cancer |
| Q50168053 | PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation |
| Q35349562 | PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation |
| Q43701623 | PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression |
| Q34409067 | PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells |
| Q42727150 | PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity |
| Q45904675 | PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer. |
| Q52009461 | PTEN is required for the normal progression of gastrulation by repressing cell proliferation after MBT in Xenopus embryos. |
| Q34761941 | PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression |
| Q37092758 | PTEN mutation, methylation and expression in breast cancer patients |
| Q39176925 | PTEN proteoforms in biology and disease |
| Q36497447 | PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). |
| Q35146572 | PTEN signaling pathways in melanoma |
| Q39844741 | PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma |
| Q34540849 | PTEN: The down side of PI 3-kinase signalling. |
| Q37270432 | PTEN: a new guardian of the genome. |
| Q33602963 | Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis |
| Q36781253 | Peroxisome proliferator activated receptor α ligands as anticancer drugs targeting mitochondrial metabolism |
| Q39610261 | Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells |
| Q36963374 | Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer |
| Q40854521 | Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells |
| Q34316184 | Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis. |
| Q40781206 | Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal states |
| Q40725486 | Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation |
| Q34135631 | Phosphatidylinositol 3-kinases in tumor progression |
| Q35550765 | Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation |
| Q40488705 | Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells |
| Q40769024 | Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death |
| Q37459257 | Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells |
| Q34101673 | Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex |
| Q22254305 | Phosphorylation of the PTEN tail regulates protein stability and function |
| Q37594392 | Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death |
| Q35935664 | Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis |
| Q24316318 | Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity |
| Q35147039 | Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model |
| Q51073086 | Protein kinase B beta/Akt2 plays a specific role in muscle differentiation. |
| Q35146110 | Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation |
| Q48365244 | Pten Regulates Retinal Amacrine Cell Number by Modulating Akt, Tgfβ, and Erk Signaling. |
| Q37215885 | Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes |
| Q60300261 | Quadruple Negative Breast Cancers (QNBC) Demonstrate Subtype Consistency among Primary and Recurrent or Metastatic Breast Cancer |
| Q52722394 | RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines. |
| Q34189695 | RRM1-induced metastasis suppression through PTEN-regulated pathways |
| Q30433703 | Rac1 is essential for basement membrane-dependent epiblast survival |
| Q39144903 | Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. |
| Q40658383 | Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis |
| Q92661391 | Recent Research Advances in Mitosis during Mammalian Gametogenesis |
| Q39136055 | Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers |
| Q84083766 | Reduced expression of PTEN protein and its prognostic significance in the gastrointestinal stromal tumor |
| Q47669969 | Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies |
| Q43675251 | Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling |
| Q39271041 | Regulation of the tumor suppressor PTEN by SUMO. |
| Q38695875 | Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt. |
| Q90253669 | Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA |
| Q24794042 | Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo |
| Q50526804 | Role of GSK-3β in Regulation of Canonical Wnt/β-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer. |
| Q42452984 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells |
| Q36899622 | Role of TRPM2 in cell proliferation and susceptibility to oxidative stress |
| Q42236733 | Role of phosphatidylinositol 3-kinase (PI3K) and Akt1 kinase in porcine reproductive and respiratory syndrome virus (PRRSV) replication |
| Q33966221 | Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. |
| Q39460820 | Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells |
| Q28572867 | Role of the integrin-linked kinase (ILK) in determining neuronal polarity |
| Q37127301 | Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications |
| Q36670785 | Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells. |
| Q89360870 | SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling |
| Q34410598 | SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations. |
| Q40032390 | STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells |
| Q39007397 | SUMOylation regulates AKT1 activity. |
| Q33559757 | Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL |
| Q35939806 | Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells |
| Q35224775 | Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases |
| Q37698902 | SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers |
| Q90245099 | Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma |
| Q24293737 | Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation |
| Q38920132 | Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis |
| Q42713803 | Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway |
| Q34658958 | TSC2 deficiency increases PTEN via HIF1alpha |
| Q36150842 | Targeted therapies for prostate cancer |
| Q28343581 | Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions |
| Q35931554 | Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation |
| Q35911227 | The Akt signaling pathway: an emerging therapeutic target in malignant melanoma. |
| Q35469548 | The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells |
| Q33828931 | The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling |
| Q37506648 | The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma |
| Q42481082 | The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells |
| Q37736437 | The Par3 polarity protein is an exocyst receptor essential for mammary cell survival |
| Q21145899 | The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling |
| Q24683845 | The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover |
| Q37656357 | The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. |
| Q41867465 | The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death |
| Q39530881 | The mitochondrial permeability transition pore regulates endothelial bioenergetics and angiogenesis. |
| Q39697902 | The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling |
| Q37454384 | The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. |
| Q34808464 | The role of PTEN in chronic growth hormone-induced hepatic insulin resistance |
| Q37270446 | The role of PTEN signaling perturbations in cancer and in targeted therapy |
| Q40796029 | The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line |
| Q73322454 | The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis |
| Q24631438 | Therapeutic Implications of Targeting AKT Signaling in Melanoma |
| Q46601914 | Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma |
| Q37039957 | Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness |
| Q54331857 | Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells. |
| Q37716386 | Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer |
| Q40892936 | Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor |
| Q34286691 | Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation |
| Q54966913 | Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. |
| Q44730673 | Translational regulation of terminal oligopyrimidine mRNAs induced by serum and amino acids involves distinct signaling events |
| Q57741132 | Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors |
| Q49713433 | Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain. |
| Q34574432 | Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane |
| Q36364880 | Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation |
| Q33803449 | Tumor-suppressor activity of RRIG1 in breast cancer |
| Q28086901 | Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research |
| Q38790000 | Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation |
| Q41746189 | Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. |
| Q37256834 | mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome |
| Q36316304 | p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB |
| Q39742724 | p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas |
| Q39820138 | p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. |
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