| scholarly article | Q13442814 |
| P2093 | author name string | A Gray | |
| C P Downes | |||
| N R Leslie | |||
| E A Orchiston | |||
| I Pass | |||
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region | Q22010498 | ||
| Mechanism of activation of protein kinase B by insulin and IGF-1 | Q24309528 | ||
| TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein | Q24534146 | ||
| PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane | Q24563377 | ||
| Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway | Q24653458 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| The small GTP-binding protein rac regulates growth factor-induced membrane ruffling | Q27861063 | ||
| MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines | Q28256046 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
| The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway | Q28611339 | ||
| Recognition of unique carboxyl-terminal motifs by distinct PDZ domains | Q29547580 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase | Q29618387 | ||
| Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs | Q30175793 | ||
| PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells | Q33586807 | ||
| PTEN: a tumour suppressor that functions as a phospholipid phosphatase | Q33594251 | ||
| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
| Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity | Q33774967 | ||
| PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. | Q33860504 | ||
| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 | ||
| Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. | Q36301565 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Phosphoinositide 3-kinases: a conserved family of signal transducers | Q38556727 | ||
| Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. | Q39630940 | ||
| Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase | Q40972780 | ||
| The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells | Q40993616 | ||
| Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway | Q41036881 | ||
| Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling | Q41471394 | ||
| Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 | ||
| TRP trapped in fly signaling web. | Q47754201 | ||
| Germline mutations in PTEN are present in Bannayan-Zonana syndrome | Q48046915 | ||
| Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. | Q48331127 | ||
| Structure and function of phosphoinositide 3-kinases. | Q52532836 | ||
| High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
| Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion | Q74037504 | ||
| Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK | Q77387406 | ||
| The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene | Q77726383 | ||
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 827-833 | |
| P577 | publication date | 2000-03-01 | |
| P1433 | published in | Biochemical Journal | Q864221 |
| P1476 | title | Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase | |
| P478 | volume | 346 Pt 3 |
| Q33641237 | A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise. |
| Q30477420 | A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells |
| Q40839096 | A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B. |
| Q36973814 | Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy |
| Q91644083 | Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia |
| Q40618985 | Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy |
| Q35915549 | Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development |
| Q24519078 | Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins |
| Q35435345 | Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines |
| Q30487052 | Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas. |
| Q30884393 | Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. |
| Q28217868 | PTEN associates with the vault particles in HeLa cells |
| Q35282160 | PTEN controls tumor-induced angiogenesis |
| Q24528114 | PTEN function: how normal cells control it and tumour cells lose it |
| Q39388363 | PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity |
| Q37655023 | PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer |
| Q24303571 | PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling |
| Q36646490 | PTEN/MMAC1 expression in melanoma resection specimens |
| Q24317335 | Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN |
| Q24316318 | Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity |
| Q36995391 | Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. |
| Q41883384 | Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons |
| Q37331720 | Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. |
| Q29568312 | Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway |
| Q28364566 | TPIP: a novel phosphoinositide 3-phosphatase |
| Q28343581 | Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions |
| Q40154931 | Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. |
| Q34244242 | The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms |
| Q24290417 | The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation |
| Q40601438 | The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif |
| Q39736424 | Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. |
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