scholarly article | Q13442814 |
P50 | author | Roumen Pankov | Q40664105 |
P2093 | author name string | K Matsumoto | |
K M Yamada | |||
T Takino | |||
M Tamura | |||
J Gu | |||
E H Danen | |||
P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration | Q24318859 | ||
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src | Q24320223 | ||
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases | Q24323070 | ||
The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation | Q24532185 | ||
Regulation of cell motility by mitogen-activated protein kinase | Q24678874 | ||
Cell migration: a physically integrated molecular process | Q27860682 | ||
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia | Q27861126 | ||
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein | Q28114826 | ||
Signaling Through Scaffold, Anchoring, and Adaptor Proteins | Q28131792 | ||
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway | Q28139300 | ||
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth | Q28282803 | ||
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration | Q28369093 | ||
Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells | Q28586458 | ||
Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events | Q28609216 | ||
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase | Q28646514 | ||
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice | Q29617498 | ||
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases | Q29618331 | ||
Transformation of mammalian cells by constitutively active MAP kinase kinase | Q29618686 | ||
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness | Q29620446 | ||
Requirements for localization of p130cas to focal adhesions | Q30176494 | ||
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells | Q33586807 | ||
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation | Q34133504 | ||
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src | Q34580219 | ||
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression | Q36067596 | ||
Fibronectin receptor exhibits high lateral mobility in embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cells | Q36219402 | ||
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly | Q36234598 | ||
The chemotactic response to PDGF-BB: evidence of a role for Ras. | Q36235836 | ||
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity | Q36237442 | ||
Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts | Q36254663 | ||
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways | Q36256326 | ||
Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated | Q36383309 | ||
Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons | Q36750000 | ||
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation | Q37381921 | ||
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase | Q38330900 | ||
Forces exerted by locomoting cells | Q40627374 | ||
Recent quantitative studies of actin filament turnover during cell locomotion | Q40861273 | ||
On the crawling of animal cells | Q40907482 | ||
Adhesion in cell migration | Q40952555 | ||
Integrin ligation and PKC activation are required for migration of colon carcinoma cells | Q41008602 | ||
Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner | Q41021037 | ||
Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway | Q41024604 | ||
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K | Q41075804 | ||
Neural crest cell locomotion induced by antibodies to beta 1 integrins. A tool for studying the roles of substratum molecular avidity and density in migration | Q41139545 | ||
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras | Q41483761 | ||
Regulation of chemotaxis by the platelet-derived growth factor receptor-beta | Q41488423 | ||
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. | Q41564910 | ||
Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines | Q41676572 | ||
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function | Q41848857 | ||
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger | Q42645065 | ||
The adaptor protein Shc couples a class of integrins to the control of cell cycle progression | Q42807056 | ||
Controlled induction of focal adhesion disassembly and migration in primary fibroblasts. | Q42809072 | ||
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC | Q42824933 | ||
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer | Q45029660 | ||
Cell migration: regulation of force on extracellular-matrix-integrin complexes | Q47721637 | ||
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. | Q48331127 | ||
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. | Q52180037 | ||
Functional domains of the insulin receptor responsible for chemotactic signaling. | Q52219133 | ||
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin | Q67020082 | ||
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn | Q71593826 | ||
Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion | Q74037504 | ||
Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration | Q77353628 | ||
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene | Q77726383 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 389-403 | |
P577 | publication date | 1999-07-01 | |
P1433 | published in | Journal of Cell Biology | Q1524550 |
P1476 | title | Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. | |
P478 | volume | 146 |
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Q28201567 | A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated |
Q44170741 | A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis |
Q30309688 | Adaptive mechanisms induced by long-term estrogen deprivation in breast cancer cells |
Q24301574 | Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells |
Q45869247 | Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo |
Q27314883 | Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes |
Q40836678 | Alternative splicing of the human PTEN/MMAC1/TEP1 gene |
Q36153774 | Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules |
Q38314871 | Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase |
Q30558614 | Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells |
Q54436502 | Association of sporadic breast cancer with PTEN/MMAC1/TEP1 promoter hypermethylation |
Q39410384 | Automatic cell tracking applied to analysis of cell migration in wound healing assay |
Q34103311 | Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo |
Q44572786 | Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation |
Q34840579 | Biological aspects of signal transduction by cell adhesion receptors |
Q34444274 | Biological mechanisms of glioma invasion and potential therapeutic targets |
Q47925582 | Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. |
Q42803219 | Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation |
Q43993793 | Calcium oscillations trigger focal adhesion disassembly in human U87 astrocytoma cells |
Q34425717 | Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2. |
Q41838103 | Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death |
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Q38304039 | Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration |
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Q28353893 | Dynamic modules and heterogeneity of function: a lesson from tyrosine kinase receptors in endothelial cells |
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Q34527534 | Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells |
Q35745799 | Epigenetic PTEN silencing in malignant melanomas without PTEN mutation |
Q35865016 | Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma |
Q28144169 | FAK integrates growth-factor and integrin signals to promote cell migration |
Q30370419 | FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm |
Q36006472 | Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis |
Q42784215 | Focal adhesion kinase (FAK) and mechanical stimulation negatively regulate the transition of airway smooth muscle tissues to a synthetic phenotype |
Q43688564 | Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells |
Q33944467 | Focal adhesion kinase is involved in mechanosensing during fibroblast migration |
Q35842249 | Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas |
Q28273098 | Fyn: a novel molecular target in cancer |
Q45742683 | Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling |
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Q73410694 | Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues |
Q39975483 | High shear flow induces migration of adherent human platelets |
Q45943269 | Host cell transcriptome modification upon exogenous HPV16 L2 protein expression. |
Q98733448 | ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells |
Q30884393 | Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. |
Q41758432 | Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling |
Q30440155 | In vivo dynamics of Rac-membrane interactions |
Q34572332 | Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo |
Q47164766 | Insights into the Shc Family of Adaptor Proteins. |
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Q34283477 | Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas. |
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