Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

scientific article

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.146.2.389
P932PMC publication ID2156182
P698PubMed publication ID10427092
P5875ResearchGate publication ID236239846

P50authorRoumen PankovQ40664105
P2093author name stringK Matsumoto
K M Yamada
T Takino
M Tamura
J Gu
E H Danen
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell MigrationQ24318859
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-SrcQ24320223
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatasesQ24323070
The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferationQ24532185
Regulation of cell motility by mitogen-activated protein kinaseQ24678874
Cell migration: a physically integrated molecular processQ27860682
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor proteinQ28114826
Signaling Through Scaffold, Anchoring, and Adaptor ProteinsQ28131792
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathwayQ28139300
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growthQ28282803
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migrationQ28369093
Pten is essential for embryonic development and tumour suppressionQ28509238
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cellsQ28586458
Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation EventsQ28609216
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinaseQ28646514
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinasesQ29618331
Transformation of mammalian cells by constitutively active MAP kinase kinaseQ29618686
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessQ29620446
Requirements for localization of p130cas to focal adhesionsQ30176494
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferationQ34133504
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-srcQ34580219
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Fibronectin receptor exhibits high lateral mobility in embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cellsQ36219402
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assemblyQ36234598
The chemotactic response to PDGF-BB: evidence of a role for Ras.Q36235836
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinityQ36237442
Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblastsQ36254663
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulatedQ36383309
Contact and adhesive specificities in the associations, migrations, and targeting of cells and axonsQ36750000
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferationQ37381921
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinaseQ38330900
Forces exerted by locomoting cellsQ40627374
Recent quantitative studies of actin filament turnover during cell locomotionQ40861273
On the crawling of animal cellsQ40907482
Adhesion in cell migrationQ40952555
Integrin ligation and PKC activation are required for migration of colon carcinoma cellsQ41008602
Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent mannerQ41021037
Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathwayQ41024604
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)KQ41075804
Neural crest cell locomotion induced by antibodies to beta 1 integrins. A tool for studying the roles of substratum molecular avidity and density in migrationQ41139545
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21rasQ41483761
Regulation of chemotaxis by the platelet-derived growth factor receptor-betaQ41488423
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.Q41564910
Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell linesQ41676572
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector functionQ41848857
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.Q42610778
Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces albonigerQ42645065
The adaptor protein Shc couples a class of integrins to the control of cell cycle progressionQ42807056
Controlled induction of focal adhesion disassembly and migration in primary fibroblasts.Q42809072
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMACQ42824933
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transferQ45029660
Cell migration: regulation of force on extracellular-matrix-integrin complexesQ47721637
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.Q48331127
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.Q52180037
Functional domains of the insulin receptor responsible for chemotactic signaling.Q52219133
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectinQ67020082
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and FynQ71593826
Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma InvasionQ74037504
Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migrationQ77353628
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogeneQ77726383
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)389-403
P577publication date1999-07-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleShc and FAK differentially regulate cell motility and directionality modulated by PTEN.
P478volume146

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Q30443138The role of PTEN in prostate cancer cell tropism to the bone micro-environment
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Q31485514Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes
Q33984914Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation
Q38503419Use of angiotensin-converting enzyme inhibitors in the prophylaxis of anthracycline or trastuzumab-related cardiac dysfunction: preclinical and clinical considerations
Q24633165c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion
Q40407116mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
Q41619834p66Shc couples mechanical signals to RhoA through FAK-dependent recruitment of p115-RhoGEF and GEF-H1.
Q37867129p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress
Q37073926p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 mem
Q36323184uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
Q42450372v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts

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