Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene

scientific article

Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3748/WJG.V11.I15.2224
P932PMC publication ID4305803
P698PubMed publication ID15818730
P5875ResearchGate publication ID276325100

P2093author name stringYan Cao
Ying Hang
Yu-Jie Sui
Qing-Shan Li
Yong-Chen Zheng
P2860cites workThe tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).Q33606105
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cellsQ33965618
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.Q34742581
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanomaQ36260162
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.Q36301565
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.Q39457088
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cellsQ40993616
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexesQ41667743
PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.Q41925995
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cellsQ42481082
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.Q44846579
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.Q45029660
Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN geneQ45864448
p27Kip1 is required for PTEN-induced G1 growth arrest.Q46585082
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancersQ47720095
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.Q48331127
Somatic mutations of PTEN in glioblastoma multiformeQ48618632
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.Q52180037
Frequent inactivation of PTEN/MMAC1 in primary prostate cancerQ57240096
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell deathQ73400418
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignanciesQ73722520
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogeneQ77726383
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)2224-2229
P577publication date2005-04-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleSuppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene
P478volume11

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cites work (P2860)
Q39325807Arsenic trioxide induces G2/M arrest in hepatocellular carcinoma cells by increasing the tumor suppressor PTEN expression
Q39521543Down-regulated miRNA-214 induces a cell cycle G1 arrest in gastric cancer cells by up-regulating the PTEN protein
Q44577628Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer
Q39093740Genistein induces G2/M arrest in gastric cancer cells by increasing the tumor suppressor PTEN expression
Q34235604Prostate cancer-specific and potent antitumor effect of a DD3-controlled oncolytic virus harboring the PTEN gene

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