| scholarly article | Q13442814 |
| P2093 | author name string | C Brandts | |
| M Wong | |||
| L Reilly | |||
| V Taylor | |||
| L M Cowsert | |||
| N M Dean | |||
| D Stokoe | |||
| S Moodie | |||
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase | Q22253894 | ||
| Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B | Q24309564 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase | Q24336639 | ||
| Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 | Q24531380 | ||
| The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase | Q24567715 | ||
| Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA | Q24568308 | ||
| Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma | Q24604935 | ||
| Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway | Q24653458 | ||
| A simplified system for generating recombinant adenoviruses | Q24682328 | ||
| Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase | Q24682825 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B | Q28116107 | ||
| PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells | Q28236975 | ||
| A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate | Q28254402 | ||
| Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP | Q28254532 | ||
| Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein | Q28276173 | ||
| p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity | Q28280824 | ||
| Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 | Q28285431 | ||
| The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity | Q28289470 | ||
| Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate | Q28301966 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site | Q28373472 | ||
| Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling | Q28581883 | ||
| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway | Q28588309 | ||
| Role of translocation in the activation and function of protein kinase B | Q28609902 | ||
| Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation | Q28616026 | ||
| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha | Q28616168 | ||
| Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 | ||
| Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment | Q29615852 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association. | Q30176624 | ||
| Essential role for the C-terminal noncatalytic region of SHIP in FcgammaRIIB1-mediated inhibitory signaling | Q30305586 | ||
| The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells | Q30472928 | ||
| PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells | Q33586807 | ||
| PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. | Q33860504 | ||
| Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate | Q34466007 | ||
| The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation | Q36310121 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program | Q36845878 | ||
| Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase | Q39577792 | ||
| An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement | Q39610838 | ||
| A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. | Q40020748 | ||
| SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival | Q40443155 | ||
| FcgammaRIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells | Q40957381 | ||
| The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells | Q40993616 | ||
| Phosphoinositide 3-kinase and the regulation of cell growth | Q41078881 | ||
| Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization | Q41120523 | ||
| The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation | Q41151188 | ||
| Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. | Q41166947 | ||
| Mutation of the conserved domains of two inositol polyphosphate 5-phosphatases | Q41191015 | ||
| PI3K: downstream AKTion blocks apoptosis | Q41351876 | ||
| Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes | Q41667743 | ||
| The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling | Q42462089 | ||
| Distribution of the src-homology-2-domain-containing inositol 5-phosphatase SHIP-2 in both non-haemopoietic and haemopoietic cells and possible involvement of SHIP-2 in negative signalling of B-cells | Q42811183 | ||
| Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 | ||
| Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression | Q43806330 | ||
| PTEN and inherited hamartoma-cancer syndromes | Q47852476 | ||
| PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. | Q55476772 | ||
| High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity | Q57986498 | ||
| Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas | Q72016451 | ||
| Enzymatic activity of the Src homology 2 domain-containing inositol phosphatase is regulated by a plasma membrane location | Q73675868 | ||
| P433 | issue | 18 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | glioblastoma | Q282142 |
| P304 | page(s) | 6860-6871 | |
| P577 | publication date | 2000-09-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells | |
| P478 | volume | 20 |
| Q39979475 | A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. |
| Q40445488 | Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication |
| Q44647433 | Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells |
| Q45869247 | Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo |
| Q30478648 | Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation |
| Q36973814 | Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy |
| Q37945234 | Anti-apoptotic effect of Tax: an NF-κB path or a CREB way? |
| Q34321332 | Bisperoxovanadium compounds are potent PTEN inhibitors. |
| Q28078208 | Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate |
| Q24317707 | Charting the molecular network of the drug target Bcr-Abl |
| Q37109227 | Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. |
| Q37631723 | Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells |
| Q33277534 | Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth |
| Q35058356 | Discovery and development of small molecule SHIP phosphatase modulators |
| Q92258266 | Downregulation of SHIP2 by Hepatitis B Virus X Promotes the Metastasis and Chemoresistance of Hepatocellular Carcinoma through SKP2 |
| Q39504317 | Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability |
| Q34694755 | High SHIP2 expression indicates poor survival in colorectal cancer |
| Q39155362 | How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? |
| Q90397006 | IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity |
| Q34747123 | In situ detection of phospholipid and phosphoinositide metabolism |
| Q40615155 | Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias |
| Q38223317 | Inositol lipid phosphatases in membrane trafficking and human disease. |
| Q50481460 | Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. |
| Q34184917 | Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. |
| Q35635353 | JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis |
| Q36438742 | Lipid phosphatases as drug discovery targets for type 2 diabetes. |
| Q37451135 | Mechanisms of resistance to EGFR inhibitors in head and neck cancer |
| Q39470573 | Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene |
| Q36862768 | Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response |
| Q24551012 | Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity |
| Q33738762 | PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells |
| Q34389540 | PKB/AKT: functional insights from genetic models |
| Q34202681 | PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control |
| Q42811887 | PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells |
| Q34540849 | PTEN: The down side of PI 3-kinase signalling. |
| Q38127844 | Perifosine--a new option in treatment of acute myeloid leukemia? |
| Q38879505 | Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease |
| Q40750094 | Phosphatidylinositol 3-kinase is essential for the proliferation of lymphoblastoid cells |
| Q38572786 | Phosphatidylinositolphosphate phosphatase activities and cancer |
| Q36866978 | Phosphoinositide phosphatases in a network of signalling reactions |
| Q40769024 | Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death |
| Q40456737 | Phosphorylation of both EGFR and ErbB2 is a reliable predictor of prostate cancer cell proliferation in response to EGF. |
| Q40492430 | Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells |
| Q24541325 | Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry |
| Q37399361 | Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation |
| Q44230853 | Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade |
| Q34966603 | Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging |
| Q24338807 | SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor |
| Q42157035 | SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels |
| Q28190360 | SHIP-2 Inositol Phosphatase Is Inducibly Expressed in Human Monocytes and Serves to Regulate Fcγ Receptor-mediated Signaling |
| Q44504090 | SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles |
| Q37479242 | SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor |
| Q37763949 | SHIP2 and its involvement in various diseases |
| Q24296643 | SHIP2 interaction with the cytoskeletal protein Vinexin |
| Q30155578 | SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties |
| Q28216309 | SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line |
| Q38788518 | SHIP2: Structure, Function and Inhibition |
| Q41329955 | Structural basis for interdomain communication in SHIP2 providing high phosphatase activity |
| Q54257572 | Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt. |
| Q35010842 | Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene |
| Q28343581 | Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions |
| Q40154931 | Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. |
| Q24685244 | The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin |
| Q28188461 | The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells |
| Q39252524 | The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. |
| Q35077647 | The host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virus |
| Q35857125 | The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling. |
| Q34069966 | The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics |
| Q41902860 | The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. |
| Q41847084 | The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain. |
| Q35814123 | The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation |
| Q28645742 | The protein kinase B/Akt signalling pathway in human malignancy |
| Q35147412 | The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases |
| Q34467090 | Thrombopoietin: a pan-hematopoietic cytokine |
| Q35858762 | Transcriptional Profiling Identifies Location-Specific and Breed-Specific Differentially Expressed Genes in Embryonic Myogenesis in Anas Platyrhynchos |
| Q90372564 | Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma |
| Q28203012 | Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway |
| Q37270444 | Understanding PTEN regulation: PIP2, polarity and protein stability |
| Q102058973 | YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA |
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