Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo

scientific article published on November 1, 2003

Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1004379147
P356DOI10.1038/SJ.GT.3302100
P953full work available at URLhttps://www.nature.com/articles/3302100
https://www.nature.com/articles/3302100.pdf
P698PubMed publication ID14528320
P5875ResearchGate publication ID9064537

P2093author name stringY. Saito
R. Ramesh
S. Chada
A. M. Mhashilkar
C. D. Branch
R. Schrock
X. Swanson
Y. Oida
L. Zumstein
P2860cites workPTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancersQ47720095
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivoQ64378714
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell deathQ73400418
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionQ22010498
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15Q24563116
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216Q28247771
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding siteQ28610026
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).Q33606105
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cellsQ33965618
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.Q34742581
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanomaQ36260162
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.Q36301565
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.Q39457088
PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.Q41925995
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cellsQ42481082
The cdc25 protein contains an intrinsic phosphatase activityQ46716281
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectgeneticsQ7162
colorectal cancerQ188874
AdenoviridaeQ193447
molecular medicineQ3523816
colorectal carcinomaQ25493920
P304page(s)1961-1969
P577publication date2003-11-01
P1433published inGene TherapyQ15763095
P1476titleAdenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo
P478volume10