| scholarly article | Q13442814 |
| P2093 | author name string | K M Yamada | |
| M Tamura | |||
| J Gu | |||
| P2860 | cites work | JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain | Q24308838 |
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src | Q24320223 | ||
| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Protein modules and signalling networks | Q27860694 | ||
| Integrins: versatility, modulation, and signaling in cell adhesion | Q27860844 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| PTEN1 is frequently mutated in primary endometrial carcinomas | Q28250937 | ||
| A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth | Q28282803 | ||
| Integrins: emerging paradigms of signal transduction | Q28283614 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events | Q28609216 | ||
| Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase | Q28646514 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases | Q29618331 | ||
| Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells | Q29618480 | ||
| Transformation of mammalian cells by constitutively active MAP kinase kinase | Q29618686 | ||
| Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation | Q30452661 | ||
| Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation | Q30452710 | ||
| Signal transduction through integrins: a central role for focal adhesion kinase? | Q30464970 | ||
| Growth factor activation of MAP kinase requires cell adhesion. | Q33887464 | ||
| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 | ||
| Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly | Q36234598 | ||
| Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts | Q36254663 | ||
| Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors | Q36257661 | ||
| Integrins, oncogenes, and anchorage independence. | Q36276579 | ||
| Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation | Q36525558 | ||
| Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase | Q36567534 | ||
| Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain | Q36818855 | ||
| Molecular themes in oncogenesis | Q37625792 | ||
| Extracellular matrix modulates epidermal growth factor receptor activation in rat glomerular epithelial cells | Q40345685 | ||
| Integrin transmembrane signaling and cytoskeletal control | Q40952551 | ||
| Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras | Q41483761 | ||
| Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
| Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger | Q42645065 | ||
| The adaptor protein Shc couples a class of integrins to the control of cell cycle progression | Q42807056 | ||
| Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected]. | Q42810800 | ||
| Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization | Q42811833 | ||
| MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos. | Q42829269 | ||
| Integrin-mediated cell adhesion activates mitogen-activated protein kinases. | Q42833091 | ||
| Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. | Q45029660 | ||
| Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway | Q46217115 | ||
| Germline mutations in PTEN are present in Bannayan-Zonana syndrome | Q48046915 | ||
| Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2 | Q72391840 | ||
| Cell-to-cell contact and extracellular matrix | Q93903473 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1375-1383 | |
| P577 | publication date | 1998-11-01 | |
| P1433 | published in | Journal of Cell Biology | Q1524550 |
| P1476 | title | Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways | |
| P478 | volume | 143 |
| Q35128009 | 3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex |
| Q37324522 | A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells |
| Q33929512 | A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. |
| Q29568319 | A role for nuclear PTEN in neuronal differentiation. |
| Q44170741 | A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis |
| Q61813438 | ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis |
| Q38963519 | Actin cytoskeleton organization, cell surface modification and invasion rate of 5 glioblastoma cell lines differing in PTEN and p53 status. |
| Q44647433 | Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells |
| Q45869247 | Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo |
| Q40836678 | Alternative splicing of the human PTEN/MMAC1/TEP1 gene |
| Q35535596 | Association of p75(NTR) and α9β1 integrin modulates NGF-dependent cellular responses |
| Q29568324 | Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload |
| Q49061270 | Brain tumour invasion: Many cooks can spoil the broth |
| Q28278854 | Cancer phenomics: RET and PTEN as illustrative models |
| Q49410803 | Colorectal polyposis and inherited colorectal cancer syndromes |
| Q39804055 | Combination gene therapy with PTEN and EGFR siRNA suppresses U251 malignant glioma cell growth in vitro and in vivo |
| Q47142338 | Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance |
| Q90047400 | Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer |
| Q52052243 | De novo t(7;10)(q33;q23) translocation and closely juxtaposed microdeletion in a patient with macrocephaly and developmental delay. |
| Q37452346 | Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction |
| Q35069243 | Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava. |
| Q37461528 | Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling |
| Q92922823 | Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression |
| Q35810225 | Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors |
| Q37175069 | Differential role of PTEN phosphatase in chemotactic growth cone guidance |
| Q36706060 | Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer |
| Q35435345 | Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines |
| Q41170725 | Dysregulation of PTEN in cardiopulmonary vascular remodeling induced by pulmonary hypertension. |
| Q44103702 | EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase |
| Q40268565 | Effects of cotransfection of antisense-EGFR and wild-type PTEN cDNA on human glioblastoma cells |
| Q40686073 | Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. |
| Q36174374 | Evaluation of PTEN immunoexpression in oral submucous fibrosis: role in pathogenesis and malignant transformation |
| Q21184033 | Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors |
| Q81228758 | Expression and significance of PTEN and VEGF in canine mammary gland tumours |
| Q36261565 | Expression of NF-κB and PTEN in primary epithelial ovarian carcinoma and the correlation with chemoresistance |
| Q54282770 | FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells. |
| Q30445295 | FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. |
| Q36956729 | Focal adhesion kinase: a promising target for anticancer therapy |
| Q34178906 | Genes that regulate metastasis and angiogenesis |
| Q38525479 | Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases |
| Q37305035 | Genetic modelling of the PTEN/AKT pathway in cancer research |
| Q35700587 | Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity |
| Q33989023 | Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancer |
| Q36178870 | Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products |
| Q53118756 | Hematopoietic Stem Cell Activity Is Regulated by Pten Phosphorylation Through a Niche-Dependent Mechanism. |
| Q56928447 | Hereditary breast cancer |
| Q73410694 | Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues |
| Q40157228 | IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells |
| Q36860719 | Identification of key regulators of pancreatic cancer progression through multidimensional systems-level analysis |
| Q77996269 | Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo |
| Q34043823 | Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer |
| Q38301253 | Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: inhibition of epidermal growth factor-induced dephosphorylation of focal adhesion kinase |
| Q28344025 | Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells |
| Q28576729 | Inhibition of neuronal phenotype by PTEN in PC12 cells |
| Q41971722 | Inhibition of transfected PTEN on human colon cancer |
| Q31807473 | Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells |
| Q39559581 | Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel |
| Q22253438 | Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase |
| Q30437740 | Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy |
| Q34184917 | Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. |
| Q98782026 | Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten |
| Q36312697 | Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa |
| Q24797910 | Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor |
| Q53390981 | Loss of tumor suppressor protein PTEN during renal carcinogenesis. |
| Q73616956 | MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival |
| Q40679352 | Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling |
| Q34991305 | Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations |
| Q24673182 | Mechanotransduction in skeletal muscle |
| Q38725879 | MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN. |
| Q34841931 | MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression |
| Q34283477 | Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas. |
| Q39097617 | Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line |
| Q38264216 | Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy |
| Q60961343 | Novel Clofarabine-Based Combinations with Polyphenols Epigenetically Reactivate Retinoic Acid Receptor Beta, Inhibit Cell Growth, and Induce Apoptosis of Breast Cancer Cells |
| Q28391204 | Nuclear PTEN levels and G2 progression in melanoma cells |
| Q40343052 | Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo |
| Q37268874 | Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN |
| Q37680192 | P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. |
| Q34133079 | PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling. |
| Q74141759 | PTEN expression is maintained in sporadic colorectal tumours |
| Q33765703 | PTEN gene and integrin signaling in cancer |
| Q30416701 | PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations |
| Q44702044 | PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpus |
| Q37977769 | PTEN in DNA damage repair |
| Q40258879 | PTEN inhibits adrenomedullin expression and function in brain tumor cells |
| Q34796595 | PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium |
| Q28202778 | PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow |
| Q35146572 | PTEN signaling pathways in melanoma |
| Q54411913 | PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3‐kinase and MAP kinase signaling |
| Q40911230 | PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. |
| Q36284520 | PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance |
| Q36753139 | PTEN, more than the AKT pathway |
| Q37698905 | PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression |
| Q39247664 | PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis |
| Q37270432 | PTEN: a new guardian of the genome. |
| Q28203387 | PTEN: one gene, many syndromes |
| Q35203208 | PTEN: tumour suppressor, multifunctional growth regulator and more |
| Q40323743 | Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells |
| Q89700534 | Phosphatase and tensin homologue: a therapeutic target for SMA |
| Q35542014 | Phosphatases in cell-matrix adhesion and migration |
| Q37418266 | Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis |
| Q34316184 | Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis. |
| Q39172025 | Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways |
| Q33862413 | Phosphoinositide phosphatases in cell biology and disease |
| Q36544734 | Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway |
| Q28508048 | Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis |
| Q38744037 | Pioglitazone induces cell growth arrest and activates mitochondrial apoptosis in human uterine leiomyosarcoma cells by a peroxisome proliferator-activated receptor γ-independent mechanism. |
| Q36924388 | Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling |
| Q38899532 | Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process |
| Q24613810 | Protean PTEN: form and function |
| Q28602310 | Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas |
| Q34707865 | Pten signaling in gliomas |
| Q24795499 | RETRACTED: TGFβ1 signaling via αVβ6 integrin |
| Q42799689 | Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins |
| Q77785363 | Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts |
| Q77342895 | Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN |
| Q33784061 | Regulation of integrin function by T cell activation: points of convergence and divergence |
| Q33525257 | Role of Nogo-A in neuronal survival in the reperfused ischemic brain |
| Q42452984 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells |
| Q79095314 | Role of PTEN and MMP‐7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma |
| Q28572050 | Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis |
| Q24290742 | SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading |
| Q36301565 | Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. |
| Q33684614 | Signaling via Alk5 controls the ontogeny of lung Clara cells. |
| Q35010842 | Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene |
| Q57185252 | T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance |
| Q47984457 | Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins |
| Q38042699 | Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. |
| Q37810478 | The PI3K signaling pathway mediates the biological effects of leptin |
| Q36396479 | The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway |
| Q34828662 | The PTEN-PI3K pathway: of feedbacks and cross-talks |
| Q34241295 | The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors |
| Q34605237 | The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia |
| Q26772035 | The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation |
| Q40596882 | The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinoma |
| Q35976355 | The complexity of PTEN: mutation, marker and potential target for therapeutic intervention |
| Q41841993 | The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway |
| Q81241238 | The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans |
| Q34656554 | The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death |
| Q41840314 | The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. |
| Q44505036 | The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells |
| Q36289377 | The role of semaphorins and their receptors in gliomas |
| Q40817321 | Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway |
| Q30175294 | Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. |
| Q38098152 | When Overgrowth Bumps Into Cancer: The PTEN-Opathies |
| Q51046620 | When overgrowth bumps into cancer: the PTEN-opathies. |
| Q39667150 | XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling |
| Q34299534 | microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion |
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