Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction

scientific article

Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI39929
P932PMC publication ID2786803
P698PubMed publication ID19884655

P50authorStanislas LyonnetQ7598948
Isabel PuigQ42783196
Pascal de Santa BarbaraQ42942206
P2093author name stringLionel Larue
Delphine Champeval
Francis Jaubert
P2860cites workTEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Chronic intestinal pseudo-obstructionQ24647826
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
PTEN: one gene, many syndromesQ28203387
Cancer phenomics: RET and PTEN as illustrative modelsQ28278854
A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ cultureQ28504866
Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalonQ28506801
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainQ28506943
Pten is essential for embryonic development and tumour suppressionQ28509238
A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient miceQ28510532
Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptorsQ28513205
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesisQ30455473
Extracellular matrix components of the peripheral pathway of chick trigeminal axonsQ30460196
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's diseaseQ33699347
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesisQ34280493
Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal modelsQ34299988
Enteric nervous system: development and developmental disturbances--part 1.Q34635136
The PTEN-PI3K pathway: of feedbacks and cross-talksQ34828662
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
Intestinal neuronal dysplasia type B: one giant ganglion is not good enoughQ36681277
Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studiesQ36827186
Tenets of PTEN tumor suppressionQ37154214
Diffuse ganglioneuromatosis in small intestine associated with neurofibromatosis type 1.Q37361005
Hereditary gastrointestinal polyposis syndromesQ39506073
Types of nerves in the enteric nervous systemQ40097710
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.Q40218278
Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasiaQ40413223
Genetic basis of endocrine disease: multiple endocrine neoplasia type 2Q40442961
GDNF availability determines enteric neuron number by controlling precursor proliferation.Q40659699
Dividing neuron precursors express neuron‐specific tubulinQ40987131
Activation of MAP kinase (ERK1/2) in human neonatal colonic enteric nervous systemQ42028430
Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.Q46011005
Spatiotemporal gene control by the Cre-ERT2 system in melanocytesQ46898473
PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathwaysQ46923172
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos diseaseQ47198015
Cre-mediated recombination in the skin melanocyte lineage.Q48273940
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivoQ48722189
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon.Q50952770
Neuronal dysplasia: A controversial pathological correlate of intestinal pseudo‐obstructionQ52099700
Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development.Q52176250
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
The tyrosinase promoter is active in a subset of vagal neural crest cells during early development in miceQ60367876
A transgenic model for studying development of the enteric nervous system in normal and aganglionic miceQ67988109
Multiple Hamartoma Syndrome (Cowden's Disease)Q69386355
Ganglioneuromatosis of the colon and extensive glycogenic acanthosis in Cowden's diseaseQ69995099
Definition and clinical significance of dysplasia in the digestive tract. Results of a meeting of the Society of Gastroenterologic Pathology of the German Society of Pathology 25 November 1989 in KronbergQ70145021
Heterogeneous mutation of the RET proto-oncogene in subpopulations of medullary thyroid carcinomaQ71046877
Involvement of the digestive tract in Cowden's diseaseQ71438959
Ganglioneuromas of the gastrointestinal tract. Relation to Von Recklinghausen disease and other multiple tumor syndromesQ72669837
Expression of the PTEN tumour suppressor protein during human developmentQ73911026
[Intestinal ganglioneuromatosis as presenting form of Cowden's syndrome in 2 brothers]Q74839838
Flanking genomic region of Tyr::Cre mice, rapid genotyping for homozygous miceQ80610923
A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case reportQ83216899
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3586-3596
P577publication date2009-11-02
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleDeletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction
P478volume119

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cites work (P2860)
Q83275156A role for Pten in paediatric intestinal dysmotility disorders
Q27322903A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus
Q37384030AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development
Q43083601Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis.
Q92576493Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum
Q36887088An unusual case of Cowden syndrome associated with ganglioneuromatous polyposis
Q38128774Classification and diagnostic criteria of variants of Hirschsprung's disease
Q38066359Development and developmental disorders of the enteric nervous system
Q50033560Development of the Enteric Nervous System: A Genetic Guide to the Perplexed
Q38558481Enteric nervous system development: A crest cell's journey from neural tube to colon.
Q26849660Enteric nervous system development: migration, differentiation, and disease
Q34635204Ex vivo neurogenesis within enteric ganglia occurs in a PTEN dependent manner
Q51762070Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.
Q38782466Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention
Q38899834Genetics of enteric neuropathies.
Q35970822Immunostaining to visualize murine enteric nervous system development
Q92060189LKB1 specifies neural crest cell fates through pyruvate-alanine cycling
Q57186379Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit
Q38883845Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players
Q38048884PTEN and melanomagenesis
Q30559287Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.
Q26750556White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

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