PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations

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PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-07-1963
P932PMC publication ID3813002
P698PubMed publication ID18339852
P5875ResearchGate publication ID5512197

P2093author name stringManish Kumar
John Laterra
Roger Abounader
Elizabeth Johnson
David Schiff
Yongde Bao
Fadila Guessous
Isa Hussaini
Yunqing Li
Bachchu Lal
Lauren Fuller
Sherwin Kwon
Opeyemi Ibidapo
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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growthQ34402080
Pten signaling in gliomasQ34707865
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein networkQ34825957
Transcriptional activities of mutant p53: when mutations are more than a lossQ35902152
p53 mutation heterogeneity in cancerQ36113160
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
Tumours and tremors: how PTEN regulation underlies bothQ36404118
Mutant p53 proteins: between loss and gain of functionQ36661775
Transcription regulation by mutant p53.Q36777349
Tumor-derived p53 mutants induce NF-kappaB2 gene expressionQ39614332
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.Q40200606
The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancyQ40360944
PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to ChemotherapyQ40765673
Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells.Q40943652
The expression of both domains of the 69/71 kDa 2',5' oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral responseQ40956174
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cellsQ40993616
Induction of senescence in human malignant glioma cells by p16INK4A.Q41098516
Gain of function mutations in p53.Q41557652
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.Q42445479
Genetic pathways to glioblastoma: a population-based studyQ44673208
p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibitionQ44762886
PTEN regulates Mdm2 expression through the P1 promoterQ44848220
PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumorsQ46682481
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
Functional evaluation of p53 and PTEN gene mutations in gliomas.Q55475014
PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent MannerQ57591077
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomasQ57591220
Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expressionQ73004517
PTEN and p53: who will get the upper hand?Q73086898
p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3Q79961068
Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cellsQ79961179
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1723-1731
P577publication date2008-03-01
P1433published inCancer ResearchQ326097
P1476titlePTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations
P478volume68

Reverse relations

cites work (P2860)
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