Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

scientific article

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1750-3639.1999.TB00536.X
P698PubMed publication ID10416987
P5875ResearchGate publication ID12882526

P50authorErwin G. Van MeirQ30503507
P2093author name stringM Tada
N Ishii
D Maier
A Merlo
Y Sawamura
A C Diserens
P2860cites workThe tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathwaysQ24321528
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53Q28266637
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrestQ28270478
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
A simple p53 functional assay for screening cell lines, blood, and tumorsQ34397902
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.Q35960464
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Genetic alterations associated with the evolution and progression of astrocytic brain tumoursQ40427187
Field cancerisation and polyclonal p53 mutation in the upper aero- digestive tractQ54953383
Frequent loss of the cyclin-dependent kinase-4 inhibitor gene in human gliomas.Q55021597
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.Q55477977
Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.Q55478215
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancersQ55480673
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locusQ57269211
Genetic instability leads to loss of both p53 alleles in a human glioblastomaQ41064852
p53 protein accumulation and gene mutations in human glioma cell linesQ41509767
Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitroQ41706700
Establishment and characterization of five cell lines derived from human malignant gliomasQ42817353
Constitutional p53 mutations associated with brain tumors in young adultsQ46575531
PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomasQ47740646
Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomasQ47775705
Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assayQ47975834
PTEN mutations in gliomas and glioneuronal tumors.Q47995275
Subsets of glioblastoma multiforme defined by molecular genetic analysisQ48379049
Intrinsic brain-stem tumors of childhood: surgical indicationsQ48391525
Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assayQ48960481
Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomasQ48972634
P4510describes a project that usesU-87MG ATCCQ7863603
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U-118MGQ54973503
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U-251MGQ54973550
U-343MGQ54973568
U-373MG ATCCQ54973575
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A-172Q54605968
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P433issue3
P921main subjectcell lineQ21014462
P304page(s)469-479
P577publication date1999-07-01
P1433published inBrain PathologyQ4955776
P1476titleFrequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
P478volume9

Reverse relations

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cites work (P2860)
Q35677134A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy
Q30501296A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells
Q38954633A critical overview of long non-coding RNA in glioma etiology 2016: an update
Q27324733A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma
Q34568957A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis
Q39320231A myeloid progenitor cell line capable of supporting human cytomegalovirus latency and reactivation, resulting in infectious progeny
Q38741033A novel cell-permeable RDP-p53 fusion protein for specific inhibition on the growth of cancerous neural cells
Q48340796A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy
Q37492151A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1.
Q33112696A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.
Q55397197A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells.
Q39236559ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
Q43098841ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells.
Q90641009AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells
Q58727164ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner
Q35103214Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma
Q57161414Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma
Q39895365Absence of GAPDH regulation in tumor-cells of different origin under hypoxic conditions in - vitro.
Q35847030Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways
Q35570177Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans
Q43600431Activation of extracellular-regulated kinases by normal and mutant EGF receptors
Q24555121Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1
Q34365378Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis
Q39680687Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity
Q40511785Alkylphosphocholine-induced glioma cell death is BCL-X(L)-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation
Q48307341Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells
Q30417011Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch
Q27683806An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging
Q40722521Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.
Q46024830Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death.
Q42170315Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines
Q39095859Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines
Q46409357Are 25 SNPs from the CARDIoGRAM study associated with ischaemic stroke?
Q64107495Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
Q34667252Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
Q39290679Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
Q37625457Autophagy and oxidative stress in gliomas with IDH1 mutations
Q39421577Bay846, a new irreversible small molecule inhibitor of EGFR and Her2, is highly effective against malignant brain tumor models
Q34293024Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types
Q38943486Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization.
Q33598840Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage
Q49516500Bioinformatical analysis of gene expression signatures of different glioma subtypes
Q24684369Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression
Q42378296Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells
Q64239669CHNO and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression
Q40616862CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death
Q33680449Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation
Q40749203Caveolin-1 expression is maintained in rat and human astroglioma cell lines
Q39700144Cetuximab insufficiently inhibits glioma cell growth due to persistent EGFR downstream signaling
Q39977339Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Q39712685Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
Q42168743Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro
Q39064313Cisplatin associated with LY294002 increases cytotoxicity and induces changes in transcript profiles of glioblastoma cells.
Q34037067Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres.
Q46232869Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1.
Q58889406Cold atmospheric plasma treatment of melanoma and glioblastoma cancer cells
Q21133610Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor model
Q34069663Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development
Q90629577Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity
Q37268884Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions
Q42222863Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry
Q61449553Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease
Q34198939Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model
Q36010078DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Q44083581DNA hypermethylation status of multiple genes in prostate adenocarcinomas
Q34994888Death pathways triggered by activated Ras in cancer cells
Q38784169Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers
Q34603835Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival
Q39646942Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter
Q35869307Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules
Q33611551Different molecular patterns in glioblastoma multiforme subtypes upon recurrence
Q60919667Differential Exosomic Proteomic Patterns and Their Influence in Resveratrol Sensitivities of Glioblastoma Cells
Q35748846Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations
Q35587229Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas
Q40237643Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines
Q44925953Down-regulation of Wilms' tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53.
Q40086566Down-regulation of the inhibitor of growth 1 (ING1) tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death
Q35061682Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells
Q36682802Dual effect of serum amyloid A on the invasiveness of glioma cells.
Q46131414Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation
Q38725917E2F transcription factors associated with up-regulated genes in glioblastoma
Q36355848EGFR blockade prevents glioma escape from BRAFV600E targeted therapy
Q37445712EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.
Q39953614Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells
Q47154528Engineering PTEN-L for Cell-Mediated Delivery.
Q40645479Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator-plasmin cascade.
Q34395707Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies
Q35845255Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation
Q38708860Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients
Q92783224Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity
Q55474355Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.
Q36361068Fermented mistletoe extract as a multimodal antitumoral agent in gliomas
Q38753773Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma.
Q35800503Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy
Q39991463Frequent and variable abnormalities in p14 tumor suppressor gene in glioma cell lines
Q33289143GAPDH is not regulated in human glioblastoma under hypoxic conditions
Q36089874GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo
Q28476300GSK3beta regulates differentiation and growth arrest in glioblastoma
Q35198623Gamma-tocotrienol and hydroxy-chavicol synergistically inhibits growth and induces apoptosis of human glioma cells.
Q40060078Gene Delivery in Neuro-Oncology
Q35143797Genes and pathways driving glioblastomas in humans and murine disease models
Q36021580Genetic and hypoxic regulation of angiogenesis in gliomas
Q37602543Glioblastoma Multiforme Oncogenomics and Signaling Pathways
Q31885912Glioma cell sensitivity to topotecan: the role of p53 and topotecan-induced DNA damage
Q33317073Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines
Q33378368Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro.
Q30318543HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression
Q92356851HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells
Q34581562HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β
Q35670756Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis
Q55242072Hierarchical closeness-based properties reveal cancer survivability and biomarker genes in molecular signaling networks.
Q47172701High-molecular-weight tropomyosins localize to the contractile rings of dividing CNS cells but are absent from malignant pediatric and adult CNS tumors
Q28190953Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5
Q34052754Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma
Q24633377Human glioma growth is controlled by microRNA-10b
Q40577599Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas
Q43918452Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability
Q53890346INK4a/Arf is required for suppression of EGFR/DeltaEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma.
Q38886482Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis
Q45398491Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells
Q33574853Immunocompetent murine models for the study of glioblastoma immunotherapy
Q46727514Inactivation of p53 sensitizes astrocytic glioma cells to BCNU and temozolomide, but not cisplatin
Q34365365Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6
Q38970906Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells
Q38323649Inhibition of N-Myc down regulated gene 1 in in vitro cultured human glioblastoma cells.
Q37022290Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo
Q54979176Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs.
Q36344771Integrative functional genomics identifies RINT1 as a novel GBM oncogene
Q33719798Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
Q37179323Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma
Q38840489Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics
Q45539872JC virus early protein detection by immunohistochemistry in progressive multifocal leukoencephalopathy: a comparative study with in situ hybridization and polymerase chain reaction.
Q26859017Keep-ING balance: tumor suppression by epigenetic regulation
Q64078949Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide
Q36192530Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death
Q41967160Late ROS accumulation and radiosensitivity in SOD1-overexpressing human glioma cells
Q38398188Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor
Q24297357Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
Q38991458Loss of Sparc in p53-null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival
Q39266398Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness
Q39354544LuIII parvovirus selectively and efficiently targets, replicates in, and kills human glioma cells.
Q37130116MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma
Q28552962MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
Q92912403MET in glioma: signaling pathways and targeted therapies
Q46296960Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
Q39370401Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme
Q34318242Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide
Q37376084Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo
Q90084125Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Q39308847Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide
Q35036059MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development
Q24336898MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
Q35017058MicroRNA-19a promotes glioma cell growth by repressing LRIG1
Q48397147Microtubule actin cross-linking factor 1, a novel target in glioblastoma.
Q92240775Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of Glioma In Vitro and In Vivo in Glioblastoma Bearing Mice
Q47325193Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status
Q39097617Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line
Q34480160Molecular biology of nervous system tumors
Q47738114Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data
Q33716257Multiparameter computational modeling of tumor invasion
Q39012877Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384.
Q34977358N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide
Q35599399NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma
Q39304886Necrosis is not induced by gadolinium neutron capture in glioblastoma multiforme cells
Q36825579Network and pathway analysis of microRNAs, transcription factors, target genes and host genes in human glioma
Q36004162New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer
Q89989620New drugs are not enough‑drug repositioning in oncology: An update
Q36635311Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Q41675187Nutlin-3a Nanodisks Induce p53 Stabilization and Apoptosis in a Subset of Cultured Glioblastoma Cells
Q35844142O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies
Q64238496On the influence of cannabinoids on cell morphology and motility of glioblastoma cells
Q42935268Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway
Q34802264Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair
Q35858003P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.
Q41864823P14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway.
Q40453259PAX6 suppresses growth of human glioblastoma cells.
Q33599207PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A
Q40453267PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
Q37719276PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors
Q30416701PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations
Q35070903PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity
Q35661819PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.
Q33958963PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.
Q37207668PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1.
Q35092641PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation
Q24303571PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
Q77361286Persistent use of misidentified cell lines and its prevention
Q27851556Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
Q48464361Pharmacologic manipulations of mitochondrial membrane potential (DeltaPsim) selectively in glioma cells
Q38985518Physiological oxygen concentration alters glioma cell malignancy and responsiveness to photodynamic therapy in vitro
Q34886884Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.
Q90145933Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory
Q59132119Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide
Q55470737Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling.
Q38208182Proteomic analysis of cerebrospinal fluid: toward the identification of biomarkers for gliomas
Q55474425Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas.
Q39689666ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro
Q39874006Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines
Q93049221Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms
Q61794392Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma
Q34739540Regulation of glioblastoma cell invasion by PKC iota and RhoB.
Q39905965Regulatory effect of nerve growth factor in alpha9beta1 integrin-dependent progression of glioblastoma.
Q39436597Repression of cancer cell senescence by PKCι.
Q40185681Repression of p53-mediated transcription by adenovirus E1B 55-kDa does not require corepressor mSin3A and histone deacetylases
Q39954297Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
Q36212896Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
Q33644048Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis
Q28750173Retracted: Differential SELEX in Human Glioma Cell Lines
Q92966660Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts
Q41917289SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans
Q38903930STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.
Q34277050Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription
Q90062681Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment
Q48939509Second primary glioblastoma
Q42370561Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacy
Q39334108Silencing of Eps8 blocks migration and invasion in human glioblastoma cell lines
Q35176325Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
Q37269355Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
Q34269290Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro
Q30391301Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer
Q28833679Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway [...]
Q26850467Sui generis: gene therapy and delivery systems for the treatment of glioblastoma
Q33989679Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors
Q35683150Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth
Q34159322Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death
Q64244322Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner
Q36546689TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo
Q35756919TRAIL and malignant glioma.
Q92541976TRPM7 Induces Mechanistic Target of Rap1b Through the Downregulation of miR-28-5p in Glioma Proliferation and Invasion
Q36488714Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4
Q37041337Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
Q27652488Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Q33780536Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential
Q39740608Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma
Q38697698Temozolomide induces autophagy in primary and established glioblastoma cells in an EGFR independent manner
Q39214188Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells
Q39627791The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
Q40862061The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme
Q34064643The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival
Q61447495The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma
Q35085317The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence
Q40782828The development of necrosis and apoptosis in glioma: experimental findings using spheroid culture systems
Q35105214The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application
Q38990450The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells.
Q28391635The future role of personalized medicine in the treatment of glioblastoma multiforme
Q64052634The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
Q46504176The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription
Q57162865The p53 Pathway in Glioblastoma
Q35296657The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM
Q34480697The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells
Q39820505The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.
Q48362692The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
Q38742530Therapeutic Hypothesis Testing With Rodent Brain Tumor Models.
Q37137412Therapeutic approaches to target cancer stem cells
Q39691784Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma
Q59134245Thioredoxin Confers Intrinsic Resistance to Cytostatic Drugs in Human Glioma Cells
Q36368481Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells
Q38956529Tocotrienol-rich fraction, [6]-gingerol and epigallocatechin gallate inhibit proliferation and induce apoptosis of glioma cancer cells.
Q61812918Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway
Q50083504Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNβ in Glioblastomas.
Q35000404U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells
Q36782143Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Q33112684Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism
Q42974434Vorinostat(SAHA) Promotes Hyper-Radiosensitivity in Wild Type p53 Human Glioblastoma Cells.
Q38899864WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.
Q38043443What We Know about the Molecular Genetics of Central Nervous System (CNS) Tumours in Malaysia
Q35751162Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression
Q39209883ZFX regulates glioma cell proliferation and survival in vitro and in vivo
Q34423084miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas
Q28307352miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors
Q36048184p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells
Q37522828p53 isoform profiling in glioblastoma and injured brain

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