NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma

scientific article published on 11 February 2015

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1003782212
P356DOI10.1186/1476-4598-14-2
P932PMC publication ID4429406
P698PubMed publication ID25971746
P5875ResearchGate publication ID276297735

P2093author name stringHui Wang
Wen-Sheng Li
Zhe Yu
Lun Luo
Zhuo-Peng Ye
Jian-Qing Pan
Xin-Jie Ning
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Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGHQ24654938
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TGF-beta signalling from cell membrane to nucleus through SMAD proteinsQ28131770
Controlling TGF-beta signalingQ28139621
Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-beta1-induced negative regulation of IL-1R/TLR signalingQ28273752
The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasmQ28585178
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microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastomaQ30407637
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Gliomagenesis: genetic alterations and mouse modelsQ34186001
Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathwayQ34411179
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The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophreniaQ34570430
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STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNAQ36110907
Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.Q36564164
miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops.Q36596742
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets.Q36659217
miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancerQ36745826
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cellsQ36937559
The TGFBeta pathway as a therapeutic target in cancer.Q37061588
The tumor suppressing effects of QKI-5 in prostate cancer: a novel diagnostic and prognostic proteinQ37610068
TGF-β as a therapeutic target in high grade gliomas - promises and challenges.Q38060439
Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survivalQ38426352
Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-κB pathwayQ39094498
The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cellsQ39210646
Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosisQ39351939
NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cellsQ39606322
Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme.Q40296913
Tumor suppressor activity of the TGF-beta pathway in human cancersQ41157801
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.Q43246655
Glioblastoma survival in the United States improved after Food and Drug Administration approval of bevacizumab: a population-based analysisQ44661518
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B geneQ48276455
SnapShot: glioblastoma multiformeQ48495755
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastomaQ48673261
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.Q52577959
TGF-beta and cancerQ81484456
P921main subjectNF-κBQ411114
P304page(s)2
P577publication date2015-02-11
P1433published inMolecular CancerQ15724585
P1476titleNF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma
P478volume14

Reverse relations

cites work (P2860)
Q36772047Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer
Q92481663C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells
Q59796239Complex role of miR-130a-3p and miR-148a-3p balance on drug resistance and tumor biology in esophageal squamous cell carcinoma
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Q65000219HOTAIRM1 competed endogenously with miR-148a to regulate DLGAP1 in head and neck tumor cells.
Q33276239IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance
Q41346414MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins
Q33648875MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations
Q92839922MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression
Q90285576PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion
Q96648272Role of different Th17 and Treg downstream signalling pathways in the pathogenesis of Staphylococcus aureus infection induced septic arthritis in mice
Q26743549The Role of Mir-148a in Cancer
Q48111289The role of the miR-148/-152 family in physiology and disease.
Q57453928Transforming Growth Factor β1 (TGF-β1)-Stimulated Integrin-Linked Kinase (ILK) Regulates Migration and Epithelial-Mesenchymal Transition (EMT) of Human Lens Epithelial Cells via Nuclear Factor κB (NF-κB)
Q37565531miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-κB and sustains NF-κB activation by decreasing Cylindromatosis expression

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