Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression

scientific article published on 4 September 2010

Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11060-010-0374-7
P932PMC publication ID3277601
P698PubMed publication ID20820871
P5875ResearchGate publication ID46159292

P50authorHelen L. FillmoreQ58802785
P2093author name stringWilliam C Broaddus
Joy L Ware
Shawn E Holt
Aaron J Clark
Archana Chidambaram
Mike Y Chen
Dana C Chan
P2860cites workRegulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1Q24313334
WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosisQ24313596
A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1Q24324095
Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1Q24337538
WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomesQ24596062
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INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.Q27933934
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damageQ28236024
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RNA editing in the Wilms' tumor susceptibility gene, WT1Q28238638
WT-1 is required for early kidney developmentQ28512266
The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cellsQ28576102
Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells.Q48544609
Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomasQ49072671
Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.Q52169566
Wilms' tumour gene 1 (WT1) in human neoplasia.Q52938297
Expression of the Wilms' tumor gene (WT1) in human leukemiasQ53490672
Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.Q54372832
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1Q67493857
Synergism of taxol and gallium nitrate in human breast carcinoma cells: schedule dependencyQ72699561
Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressorQ73025306
Induction of p21 by the Wilms' tumor suppressor gene WT1Q73235597
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxelQ74484391
Transcriptional regulation by the Wilms' tumour suppressor protein WT1Q80912149
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The candidate Wilms' tumour gene is involved in genitourinary developmentQ34189819
Paraptosis: mediation by MAP kinases and inhibition by AIP-1/AlixQ34326791
The relationship between six-month progression-free survival and 12-month overall survival end points for phase II trials in patients with glioblastoma multiformeQ35688316
WT1 influences apoptosis through transcriptional regulation of Bcl-2 family membersQ36499914
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RNA binding by the Wilms tumor suppressor zinc finger proteins.Q37426489
Alternative splicing and genomic structure of the Wilms tumor gene WT1Q37611742
Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growthQ38326365
A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines.Q38360653
Wilms tumor 1 expression in malignant gliomas and correlation of +KTS isoforms with p53 statusQ40077672
Autophagy delays apoptotic death in breast cancer cells following DNA damageQ40228732
DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cellsQ40237176
hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activationQ40241092
Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirusQ40284343
Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathwayQ40308394
WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.Q40372880
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.Q40434380
HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells.Q40464845
Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumorsQ40500190
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.Q40519472
Transcriptional activation of c-myc proto-oncogene by WT1 proteinQ40529835
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.Q40543801
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cellsQ40600919
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulationQ40688483
Downregulation of Wilms' tumor 1 protein inhibits breast cancer proliferationQ40716988
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.Q40823490
Transcriptional regulation of insulin-like growth factor-I receptor gene expression in prostate cancer cellsQ40834085
Internal translation initiation generates novel WT1 protein isoforms with distinct biological propertiesQ40937124
Type-1 insulin-like growth factor receptor reexpression in the malignant phenotype of SV40-T-immortalized human prostate epithelial cells enhances apoptosisQ41095166
The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomasQ41098050
Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cellsQ41119806
WT1 induces expression of insulin-like growth factor 2 in Wilms' tumor cellsQ41282537
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosisQ41302327
Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytesQ41438299
WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogeneQ41786212
The role of a low pH intracellular compartment in the processing, storage, and secretion of ACTH and endorphinQ41911881
The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapyQ42193837
Cyclin E is a target of WT1 transcriptional repressionQ42817131
A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1.Q42830606
Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.Q44427360
Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transductionQ44866247
Human U251MG glioma cells expressing the membrane form of macrophage colony-stimulating factor (mM-CSF) are killed by human monocytes in vitro and are rejected within immunodeficient mice via paraptosis that is associated with increased expression oQ46039988
Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells.Q46421665
Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinomaQ47221022
Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptorQ47988156
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cellsQ48211866
The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.Q48369257
Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracraniQ48527887
P433issue1
P921main subjectglioblastomaQ282142
P304page(s)87-102
P577publication date2010-09-04
P1433published inJournal of Neuro-OncologyQ15752119
P1476titleWilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression
P478volume103

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cites work (P2860)
Q52644558An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme-Role in Pathogenesis and Therapeutic Perspective.
Q38791893Combination Therapy with AKT3 and PI3KCA siRNA Enhances the Antitumor Effect of Temozolomide and Carmustine in T98G Glioblastoma Multiforme Cells.
Q47095382Function of insulin-like growth factor 1 receptor in cancer resistance to chemotherapy
Q35606589Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance
Q52846347Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma.
Q99610842Ribosomal protein QM/RPL10 positively regulates defence and protein translation mechanisms during nonhost disease resistance
Q39849637Synthesis and in vitro evaluation of [18F]BMS-754807: a potential PET ligand for IGF-1R.
Q24633750Targeting the insulin growth factor receptor 1
Q35556180The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma
Q50971977Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis.
Q37582083WT1 shRNA delivery using transferrin-conjugated PEG liposomes in an in vivo model of melanoma
Q35489149Wilms' tumor gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line

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