Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide

scientific article published on 02 November 2018

Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2018.01271
P8608Fatcat IDrelease_7jiqfjekynaivmplueshmgbiz4
P932PMC publication ID6224489
P698PubMed publication ID30450051

P50authorIwona CiechomskaQ58631767
P2093author name stringBozena Kaminska
Judyta Jackl
Marta Patrycja Marciniak
P2860cites workLC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formationQ24294635
G9a and Glp methylate lysine 373 in the tumor suppressor p53Q24298004
Functional Role of G9a Histone Methyltransferase in CancerQ26781247
Crosstalk between apoptosis, necrosis and autophagyQ26829723
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseQ27860541
Stem cells, cancer, and cancer stem cellsQ27860878
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Chromatin modifications and their functionQ27861067
Epigenetic regulation of autophagy by the methyltransferase G9aQ28115438
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3Q28214048
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
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Accumulation of low-dose BIX01294 promotes metastatic potential of U251 glioblastoma cellsQ33597842
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Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.Q33936618
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A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With GlioblastomaQ35701142
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiationQ35735009
Cyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies.Q53677022
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and modelsQ74063639
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G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancerQ35858016
Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cellsQ36026945
Postradiation sensitization of the histone deacetylase inhibitor valproic acidQ36085669
BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cellsQ36831427
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activityQ37256069
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferationQ37425389
BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells.Q37487279
The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma.Q37725428
H3K9 methyltransferase G9a and the related molecule GLP.Q37865974
Valproic acid for the treatment of malignant gliomas: review of the preclinical rationale and published clinical resultsQ38016227
The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells.Q38987638
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cellsQ38994487
Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine a-induced cell deathQ39349204
Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation.Q39450904
H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.Q39645130
Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell linesQ40126767
Cyclosporine a induces growth arrest or programmed cell death of human glioma cells.Q40387310
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.Q40438982
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cellsQ40600919
Vorinostat(SAHA) Promotes Hyper-Radiosensitivity in Wild Type p53 Human Glioblastoma Cells.Q42974434
Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294.Q44814931
Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acidQ45172727
Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cellsQ46266480
Involvement of the mismatch repair system in temozolomide-induced apoptosisQ47752780
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecttemozolomideQ425088
P304page(s)1271
P577publication date2018-11-02
P1433published inFrontiers in PharmacologyQ2681208
P1476titlePre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide
P478volume9

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cites work (P2860)
Q89605002Histone Modifying Enzymes and Chromatin Modifiers in Glioma Pathobiology and Therapy Responses
Q61446856Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells

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