Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma

scientific article published on 16 October 2015

Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDD.2015.131
P932PMC publication ID4986636
P698PubMed publication ID26470725
P5875ResearchGate publication ID282911349

P50authorEric GuerinQ56524613
Maxime LehmannQ39190256
P2093author name stringH Kessler
S Martin
M Dontenwill
S Neubauer
G Renner
F Rechenmacher
V Koenig
I Lelong-Rebel
S Bär
A-F Blandin
F Noulet
H Janouskova
J Nuesch
L Choulier
N Etienne-Selloum
P2860cites workPED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosisQ22003766
Hallmarks of Cancer: The Next GenerationQ22252312
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complexQ24306474
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic actionQ24683017
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Q27851827
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic functionQ28215522
The somatic genomic landscape of glioblastomaQ28300185
Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiformeQ28477660
Blinded by the Light: The Growing Complexity of p53Q29547590
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
Restoration of p53 function leads to tumour regression in vivoQ29618727
Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasisQ30430565
Improved grading and survival prediction of human astrocytic brain tumors by artificial neural network analysis of gene expression microarray dataQ31153954
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.Q33209208
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trialQ33417361
Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosisQ33438165
Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancerQ33955214
Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosisQ34038417
Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectinQ34103283
Nemo-like kinase is critical for p53 stabilization and function in response to DNA damageQ34153536
Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistanceQ34662363
YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cellsQ34795766
Emerging landscape of oncogenic signatures across human cancersQ35058708
RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivoQ35225270
Expression of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) in astrocytic tumors: a novel approach of correlating malignancy grade and prognosisQ48206002
Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosisQ48394930
Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3.Q53092366
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.Q54018179
Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB networkQ35807732
Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoterQ36235303
Strategies for therapeutic targeting of the p53 pathway in cancer.Q36430162
A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosisQ36678322
Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesisQ36747299
Survivin promotion of melanoma metastasis requires upregulation of α5 integrinQ37151634
Integrins in angiogenesis and lymphangiogenesisQ37170752
ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.Q37631181
Targeting survivin in cancer: the cell-signalling perspectiveQ37867746
Integrins as therapeutic targets.Q38013361
Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors.Q38161726
Survivin as a preferential target for cancer therapyQ38188377
Drugging the p53 pathway: understanding the route to clinical efficacyQ38191796
Focal adhesion signaling and therapy resistance in cancerQ38239375
The extracellular matrix modulates the hallmarks of cancerQ38266276
Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.Q38315813
E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesisQ38963822
Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells.Q38996999
Radiation-induced mitotic cell death and glioblastoma radioresistance: a new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1 alpha and survivin in U87 cellsQ39142533
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironmentsQ39147447
Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cellsQ39176861
The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomasQ39182293
Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.Q39347057
Chk2 mediates RITA-induced apoptosisQ39430270
Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and α5 Integrin UpregulationQ39661250
alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cellsQ39748375
The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.Q40093567
ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinaseQ40330305
PED mediates AKT-dependent chemoresistance in human breast cancer cellsQ40390454
FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes.Q40499562
Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-α-induced Apoptosis via the AKT/Survivin PathwayQ40629411
A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6.Q41474344
Microarray analysis verifies two distinct phenotypes of glioblastomas resistant to antiangiogenic therapyQ41809732
Differentiation therapy exerts antitumor effects on stem-like glioma cellsQ42814006
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activationQ44594112
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destructionQ46853183
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
P4510describes a project that usesImageJQ1659584
P433issue4
P921main subjectapoptotic processQ14599311
P304page(s)640-653
P577publication date2015-10-16
P1433published inCell Death & DifferentiationQ2943974
P1476titleIntegrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma
P478volume23

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cites work (P2860)
Q471348675-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins.
Q38951345Adhering towards tumorigenicity: altered adhesion mechanisms in glioblastoma cancer stem cells
Q38453709An integrated transcriptomic and computational analysis for biomarker identification in human glioma
Q92069848C16 Peptide Promotes Vascular Growth and Reduces Inflammation in a Neuromyelitis Optica Model
Q33786677Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity.
Q41670915Exploring the Role of RGD-Recognizing Integrins in Cancer
Q39404706Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells
Q37721603Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis
Q49892600Integrin-β4 is a novel transcriptional target of TAp73.
Q44411444Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update
Q38607668Predictive Role of Galectin-1 and Integrin α5β1 in Cisplatin-based Neoadjuvant Chemotherapy of Bulky Squamous Cervical Cancer
Q92164003Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
Q47099290Survivin overexpression is potentially associated with pituitary adenoma invasiveness
Q60907638TAp73 regulates ATP7A: possible implications for ageing-related diseases
Q47899475p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile
Q57147619αvβ3 INTEGRIN MEDIATES RADIORESISTANCE OF PROSTATE CANCER CELLS THROUGH REGULATION OF SURVIVIN
Q38852942αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating
Q26774789β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer

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