Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

scientific article published on 04 September 2018

Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma is …
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scholarly articleQ13442814

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P356DOI10.1007/S12017-018-8507-9
P698PubMed publication ID30182330

P50authorChunzhi ZhangQ91291964
P2093author name stringSai Liang
Wanli Yu
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulatorsQ24336898
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanismQ24600173
miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expressionQ24610377
An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastomaQ24629145
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and websiteQ24645514
IDH1 and IDH2 mutations in gliomasQ24648948
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cellsQ24649056
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer modelQ24655262
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Deletion of RDINK4/ARF enhancer: A novel mutation to "inactivate" the INK4-ARF locusQ39422458
MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expressionQ39450296
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiformeQ39606772
Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059JQ39651756
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN statusQ39756064
Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred ChemosensitivityQ39776996
Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic LesionsQ39848278
MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM.Q39990148
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrestQ39992760
Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75.Q40122040
Contribution of Notch signaling activation to human glioblastoma multiforme.Q40157837
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.Q40179252
TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cellsQ40246842
Short-Course Radiation plus Temozolomide in Elderly Patients with GlioblastomaQ40291239
MiR-429 induces apoptosis of glioblastoma cell through Bcl-2.Q40381720
MiR-126 Regulates the ERK Pathway via Targeting KRAS to Inhibit the Glioma Cell Proliferation and InvasionQ40999025
MicroRNA‑141 inhibits the self‑renewal of glioblastoma stem cells via Jagged1Q41059804
SDF1-CXCR4 Signaling Maintains Central Post-Stroke Pain through Mediation of Glial-Neuronal InteractionsQ41074630
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cellsQ41164260
A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.Q41325859
miR-133a Promotes TRAIL Resistance in Glioblastoma via Suppressing Death Receptor 5 and Activating NF-κB Signaling.Q41440890
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible systemQ41483751
Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinaseQ41639273
MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastomaQ41846503
MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.Q42123071
Modulation of chemoresponsiveness to platinum-based agents by microRNAs in cancerQ42215256
Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapyQ42288627
Serum microRNA profiling in patients with glioblastoma: a survival analysisQ42317085
Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomesQ42371249
TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3pQ42378963
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonistsQ42380563
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cellsQ36561540
MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-AQ36642299
The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.Q36756817
MiR-138 exerts anti-glioma efficacy by targeting immune checkpointsQ36785139
Apoptosis signaling pathways and lymphocyte homeostasisQ36852224
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.Q36914209
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyQ36935749
Epigenetic regulation of miRNA-211 by MMP-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivityQ37030916
Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migrationQ37081036
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesisQ37157031
MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cellsQ37187706
miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of gliomaQ37191655
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cellsQ37221453
Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expressionQ37232935
MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling.Q37253571
Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTENQ37268874
miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastomaQ37475020
Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.Q37482805
The prognostic value of a seven-microRNA classifier as a novel biomarker for the prediction and detection of recurrence in glioma patientsQ37619766
MicroRNA-564 is downregulated in glioblastoma and inhibited proliferation and invasion of glioblastoma cells by targeting TGF-β1.Q37636608
Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNA let-7eQ37641753
Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive GrowthQ37658825
MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastomaQ37694818
Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cellsQ37750917
Regulatory T cells in tumor immunityQ37762224
TGF-beta1 interactome: metastasis and beyond.Q37775435
Biomarkers downstream of RAS: a search for robust transcriptional targetsQ37780776
Targeting metabolic remodeling in glioblastoma multiformeQ37840941
Evolutionary functional analysis and molecular regulation of the ZEB transcription factorsQ37986328
Ubiquitination in signaling to and activation of IKK.Q37995681
The molecular profile of microglia under the influence of gliomaQ38008966
Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.Q38065873
Detection methods for microRNAs in clinic practiceQ38090212
Cell transfer therapy for cancer: past, present, and futureQ38205228
Glioma Stem Cells: Signaling, Microenvironment, and TherapyQ26765854
Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapiesQ26823118
Adeno-associated virus-mediated microRNA delivery and therapeuticsQ27005597
MGMT gene silencing and benefit from temozolomide in glioblastomaQ27824832
Epithelial-mesenchymal transitions in tumour progressionQ27860487
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformationQ28140810
Identification of CDK4 sequences involved in cyclin D1 and p16 bindingQ28244094
Extensive modulation of a set of microRNAs in primary glioblastomaQ28263314
TGFβ signalling in contextQ28275410
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastomaQ28280337
MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3Q28564217
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
Hypoxia--a key regulatory factor in tumour growthQ29547318
New functions for the matrix metalloproteinases in cancer progressionQ29547738
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
Inflammation meets cancer, with NF-κB as the matchmakerQ29620242
microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastomaQ30407637
Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim.Q30413140
miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastomaQ30419258
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cellsQ30430077
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenesQ30434616
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma.Q30570563
Recent developments in the use of chemotherapy in brain tumours.Q33232219
Overexpression of miR-29a reduces the oncogenic properties of glioblastoma stem cells by downregulating Quaking gene isoform 6Q33648713
Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorshipQ33719798
At the bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapyQ33732329
Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathwaysQ33764768
Cross-talk between miRNA and Notch signaling pathways in tumor development and progressionQ33801752
Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potentialQ33825657
Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarkerQ33839507
Intratumoral Lentivector-Mediated TGF-β1 Gene Downregulation As a Potent Strategy for Enhancing the Antitumor Effect of Therapy Composed of Cyclophosphamide and Dendritic CellsQ33858506
A ten-microRNA expression signature predicts survival in glioblastomaQ33869822
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenograftsQ33883897
14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiationQ33951080
Tailoring to RB: tumour suppressor status and therapeutic responseQ34040108
MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathwayQ35945582
PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loopQ35955191
miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 CellsQ36070278
VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signalingQ36127410
MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human AstrocytomaQ36139783
miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2Q36210894
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastomaQ36232178
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptorsQ36235100
MicroRNA-199a-3p suppresses glioma cell proliferation by regulating the AKT/mTOR signaling pathwayQ36278102
cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23aQ36300857
MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiformeQ36347204
Heterogeneity and plasticity of T helper cellsQ36388771
Matrix metalloproteinases: changing roles in tumor progression and metastasisQ36422976
Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3pQ36493809
NOTCH signaling as a novel cancer therapeutic targetQ36539533
miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomasQ36557234
P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expressionQ34083360
MiR-181b sensitizes glioma cells to teniposide by targeting MDM2.Q34136136
Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell linesQ34157966
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.Q34159409
MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-RasQ34193764
Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiformeQ34207182
MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in gliomaQ34221882
MicroRNAs/TP53 feedback circuitry in glioblastoma multiformeQ34262423
TGFβ in T cell biology and tumor immunity: Angel or devil?Q34276027
MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escapeQ34365811
Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastomaQ34381578
A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomasQ34427825
Tumor antigen-specific T helper cells in cancer immunity and immunotherapyQ34433202
The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cellsQ34490171
MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1.Q34575813
Activation of glioma cells generates immune tolerant NKT cellsQ34683179
Glioma cancer stem cells induce immunosuppressive macrophages/microgliaQ34992518
Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG.Q34997130
Decreased miR-106a inhibits glioma cell glucose uptake and proliferation by targeting SLC2A3 in GBM.Q35017237
MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathwayQ35051948
Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activityQ35163556
miR-135b contributes to the radioresistance by targeting GSK3β in human glioblastoma multiforme cellsQ35284695
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastomaQ35293772
14-3-3 Proteins: diverse functions in cell proliferation and cancer progressionQ35566220
Deregulation of Snai2 is associated with metastasis and poor prognosis in tongue squamous cell carcinomaQ35624074
Sumoylation of vimentin354 is associated with PIAS3 inhibition of glioma cell migrationQ35640113
A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma TherapyQ35677134
HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathwayQ35687115
miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma CellsQ35770894
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in TumorsQ35811255
MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2Q35832262
MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1.Q35839826
VSIG4 is highly expressed and correlated with poor prognosis of high-grade glioma patientsQ35941343
LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastomaQ38261762
Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells.Q38321797
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondriaQ38325201
MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.Q38336556
MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC.Q38353056
miR-19a and miR-19b overexpression in gliomasQ38395794
MiR-198 enhances temozolomide sensitivity in glioblastoma by targeting MGMT.Q38692922
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation ProgramQ38710467
MiR-217 promoted the proliferation and invasion of glioblastoma by repressing YWHAG.Q38719284
Effects of CDKN2A (p16INK4A/p14ARF) Over-Expression on Proliferation and Migration of Human Melanoma A375 CellsQ38725224
Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/β-catenin pathwayQ38729493
Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggressionQ38732546
Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastomaQ38737828
The renewed battle against RAS-mutant cancersQ38740000
Immunotherapy and radiation in glioblastoma.Q38752191
MicroRNA-34a inhibits cell proliferation and induces cell apoptosis of glioma cells via targeting of Bcl-2.Q38771273
MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptorQ38787480
MiR-608 inhibits the migration and invasion of glioma stem cells by targeting macrophage migration inhibitory factorQ38789492
miR-373 Inhibits Glioma Cell U251 Migration and Invasion by Down-Regulating CD44 and TGFBR2.Q38795514
MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1.Q38807949
MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF-β pathwayQ38810687
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastomaQ38817536
MicroRNA‑566 modulates vascular endothelial growth factor by targeting Von Hippel‑Landau in human glioblastoma in vitro and in vivoQ38819321
miR-590-3p suppresses cancer cell migration, invasion and epithelial-mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2.Q38820350
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4.Q38822348
MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1.Q38824154
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summaryQ38829244
miR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-MetQ38845681
Upregulation of miR-181a suppresses the formation of glioblastoma stem cells by targeting the Notch2 oncogene and correlates with good prognosis in patients with glioblastoma multiformeQ38847371
Presentation of Two Cases with Early Extracranial Metastases from Glioblastoma and Review of the Literature.Q38849886
Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppressionQ38857175
miR-663 Suppresses Oncogenic Function of CXCR4 in GlioblastomaQ38869719
miR-20a mediates temozolomide-resistance in glioblastoma cells via negatively regulating LRIG1 expressionQ38876901
Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinaseQ42419112
TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patientsQ42426054
Canonical NFκB signaling in myeloid cells is required for the glioblastoma growthQ42645448
New prospects on the NKG2D/NKG2DL system for oncologyQ42796257
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.Q43283510
Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology GuidelineQ43580249
Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforinQ44209275
MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutatedQ45012413
miR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1.Q45044001
Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology GuidelineQ45270171
Anti-cancer effect of R3V6 peptide-mediated delivery of an anti-microRNA-21 antisense-oligodeoxynucleotide in a glioblastoma animal modelQ45855761
Glucose metabolites, glutamate and glycerol in malignant glioma tumours during radiotherapyQ46532765
A Selective Cyclin-Dependent Kinase 4, 6 Dual Inhibitor, Ribociclib (LEE011) Inhibits Cell Proliferation and Induces Apoptosis in Aggressive Thyroid Cancer.Q47202838
Inhibition of cancer cell migration with CuS@ mSiO2-PEG nanoparticles by repressing MMP-2/MMP-9 expressionQ47215416
Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancerQ47345855
Krüppel Like Factors Family Expression in Cervical Cancer CellsQ47382515
Prognostic relevance of genetic alterations in diffuse lower-grade gliomasQ47583690
Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cellsQ47638547
Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587.Q47881690
Mesenchymal Stem Cells as Natural Bio-Factories for Exosomes Carrying miR-124a in the Treatment of GliomasQ48025819
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.Q48134470
Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cellsQ48135067
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
Macrophage migration inhibitory factor mediates viability and apoptosis of PVM/Ms through PI3K/Akt pathwayQ48202458
MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2.Q48315466
MiR-152 functions as a tumor suppressor in glioblastoma stem cells by targeting Krüppel-like factor 4.Q48545857
Radiogenomics to characterize regional genetic heterogeneity in glioblastomaQ48582092
Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastomaQ48616366
Immunocytochemical analysis of glomerular regionalization and neuronal diversity in the olfactory deutocerebrum of the spiny lobsterQ48797706
Aging and the Krüppel-like factorsQ49372792
The Wnt Transcriptional Switch: TLE Removal or Inactivation?Q49693008
HMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinomaQ49724235
PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.Q49887901
Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitorsQ49887919
Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.Q49920435
Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafishQ49977670
A 4-miRNAs signature predicts survival in glioblastoma multiforme patients.Q50225594
Metformin inhibits TGF-β1-induced epithelial-to-mesenchymal transition-like process and stem-like properties in GBM via AKT/mTOR/ZEB1 pathway.Q50327413
MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma.Q50894719
miR-124 radiosensitizes human glioma cells by targeting CDK4.Q50913359
Natural killer T cells: drivers or passengers in preventing human disease?Q51828144
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.Q52855186
MAP kinase pathway gene copy alterations in NRAS/BRAF wild-type advanced melanoma.Q54227390
miR-101 acts as a tumor suppressor by targeting Kruppel-like factor 6 in glioblastoma stem cells.Q54321491
Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways.Q54499021
Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.Q54633524
Glioblastoma multiforme metastasis outside the CNS: three case reports and possible mechanisms of escape.Q55461135
[Relationship between miR-218 and CDK6 expression and their biological impact on glioma cell proliferation and apoptosis].Q55462716
The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling.Q55463049
Role of connexin (gap junction) genes in cell growth control and carcinogenesisQ60324708
[Changes in the functional status of the myocardium after left ventricular bypass]Q71278768
Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.Q38878830
MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1.Q38883624
miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2.Q38893903
Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signatureQ38929512
MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger proteinQ38930784
MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG.Q38940603
MiR-15b targets cyclin D1 to regulate proliferation and apoptosis in glioma cellsQ38978071
Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.Q39007403
miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathwaysQ39017914
A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivoQ39026399
miR-221/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN statusQ39051241
TGF-β-induced miR10a/b expression promotes human glioma cell migration by targeting PTEN.Q39084923
Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomasQ39099065
MiRNA-329 targeting E2F1 inhibits cell proliferation in glioma cellsQ39124132
miR-125b inhibitor may enhance the invasion-prevention activity of temozolomide in glioblastoma stem cells by targeting PIAS3.Q39125450
LRIG1 dictates the chemo-sensitivity of temozolomide (TMZ) in U251 glioblastoma cells via down-regulation of EGFR/topoisomerase-2/Bcl-2.Q39126449
Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expressionQ39126470
Let-7b expression determines response to chemotherapy through the regulation of cyclin D1 in glioblastomaQ39134240
microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cellsQ39136340
Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiformeQ39147552
miR-181b modulates glioma cell sensitivity to temozolomide by targeting MEK1.Q39156112
MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma.Q39172188
Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2.Q39198008
Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cellsQ39198840
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitinationQ39199690
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cellsQ39200427
P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2.Q39230616
Effect of miR-21 and miR-30b/c on TRAIL-induced apoptosis in glioma cells.Q39281860
miR-92a is a critical regulator of the apoptosis pathway in glioblastoma with inverse expression of BCL2L11.Q39296979
MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1.Q39319071
MiR-410 regulates MET to influence the proliferation and invasion of gliomaQ39322020
The IL-10/STAT3 axis: Contributions to immune tolerance by thymus and peripherally derived regulatory T-cellsQ39385246
miR-221/222 is the regulator of Cx43 expression in human glioblastoma cellsQ39403463
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
P304page(s)452-474
P577publication date2018-09-04
P1433published inNeuroMolecular MedicineQ15716731
P1476titleAberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma
P478volume20