Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.

scientific article published in September 2006

Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1600-0854.2006.00462.X
P698PubMed publication ID17004325
P5875ResearchGate publication ID6790952

P50authorSreenivasan PonnambalamQ38801053
P2093author name stringIan C Zachary
Azadeh Bagherzadeh
Gareth J Howell
Haiyan Jia
John H Walker
Shweta Mittar
Lorna C Ewan
Helen M Jopling
P433issue9
P921main subjectendotheliumQ111140
protein ubiquitinationQ3547638
P304page(s)1270-1282
P577publication date2006-09-01
P1433published inTrafficQ1572846
P1476titleIntrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.
P478volume7

Reverse relations

cites work (P2860)
Q52843117A biphasic endothelial stress-survival mechanism regulates the cellular response to vascular endothelial growth factor A.
Q30439884A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
Q34472013A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair
Q33912279A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2
Q57161414Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma
Q39196795Adenosine triphosphate is a critical determinant for VEGFR signal during hypoxia
Q36570882An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury
Q51317921Antiangiogenic Therapeutic Potential of Peptides Derived from the Molecular Motor KIF13B that Transports VEGFR2 to Plasmalemma in Endothelial Cells.
Q34182311Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells
Q33716813Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins
Q39773007Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells
Q26771983Cell Adhesion Molecules and Ubiquitination-Functions and Significance
Q92513343Comparison of the ligand-binding properties of fluorescent VEGF-A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET
Q36273980Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells
Q37397984Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking.
Q57467572Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides
Q55413755Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat.
Q39685598Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding
Q38090234Coordination of VEGF receptor trafficking and signaling by coreceptors.
Q39527514Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast
Q34092503Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src
Q37715042Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner
Q36783457Endocytosis of receptor tyrosine kinases
Q54446981Endocytosis regulates VEGF signalling during angiogenesis.
Q35728079Endogenous vascular endothelial growth factor-A (VEGF-A) maintains endothelial cell homeostasis by regulating VEGF receptor-2 transcription
Q64289797Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
Q41921599Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation
Q30413823Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia.
Q36760264Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.
Q30838210Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses
Q36498075Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling
Q38939975Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis
Q36685121Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.
Q34416113Expression of VEGF receptors on endothelial cells in mouse skeletal muscle.
Q35314084Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells
Q41945502Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency
Q24293152Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
Q40143659Hrs is a positive regulator of VEGF and insulin signaling
Q42801018Hrs regulates the endocytic sorting of the fibroblast growth factor receptor 2b.
Q40218344Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells.
Q37625434Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
Q34624074Involvement of lysosomal degradation in VEGF-C-induced down-regulation of VEGFR-3.
Q30592335KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2
Q35800730MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation
Q36554547MicroRNA control of vascular endothelial growth factor signaling output during vascular development
Q47703386MicroRNAs in cancer metastasis and angiogenesis
Q35000925Microtubules coordinate VEGFR2 signaling and sorting
Q52717006Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.
Q47131330Multi-physics interactions drive VEGFR2 relocation on endothelial cells.
Q36869441Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1.
Q33655366Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib: a molecular imaging study
Q47915232Palmitic acid increases pro-oxidant adaptor protein p66Shc expression and affects vascularization factors in angiogenic mononuclear cells: Action of resveratrol.
Q36132737Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer
Q37222633Purinergic regulation of vascular endothelial growth factor signaling in angiogenesis
Q58413005Quantifying the phosphorylation timescales of receptor-ligand complexes: a Markovian matrix-analytic approach
Q51717661Quantum dot multiplexing for the profiling of cellular receptors.
Q42134556Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells
Q52654047Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.
Q38219954Receptor tyrosine kinases endocytosis in endothelium: biology and signaling
Q90471472Receptor-Mediated Endocytosis of VEGF-A in Rat Liver Sinusoidal Endothelial Cells
Q64069367Recombinant RGD-disintegrin DisBa-01 blocks integrin αβ and impairs VEGF signaling in endothelial cells
Q42577163Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP.
Q38012210Regulation of VEGF signaling by membrane traffic
Q34666953Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6
Q64977643SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model.
Q58771413SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Q84520249Signal transduction by vascular endothelial growth factor receptors
Q35661415Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model
Q34108757Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development
Q46079015Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.
Q36090830Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
Q50551664The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence.
Q52845770The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.
Q26796921The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
Q36905630Tubeimoside-1 suppresses tumor angiogenesis by stimulation of proteasomal VEGFR2 and Tie2 degradation in a non-small cell lung cancer xenograft model
Q42513534Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Q54976759VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling.
Q34081464VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions
Q41810895VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Q41900132VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2
Q38560836VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis
Q91726007VEGFR endocytosis regulates the angiogenesis in a mouse model of hindlimb ischemia
Q46151844VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent
Q40198221VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.
Q38874224VEGFR2-Targeted Contrast-Enhanced Ultrasound to Distinguish between Two Anti-Angiogenic Treatments.
Q48440622Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke
Q24337309Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
Q41869550Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.
Q24649056miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells
Q39411716miRNAs in vascular integrity
Q37592046microRNAs in gliomas: small regulators of a big problem