Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

scientific article published on 06 February 2017

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2017.00048
P932PMC publication ID5292565
P698PubMed publication ID28220078

P50authorAleksander S. PopelQ1642695
P2093author name stringJeffery S Isenberg
Hojjat Bazzazi
P2860cites workThrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cellsQ85232367
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Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinasesQ24311877
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The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1Q28145820
Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)Q28186833
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1Q28251463
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Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endotheliumQ28741586
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A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondinQ33763790
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Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxationQ34275612
CD47 signaling regulates the immunosuppressive activity of VEGF in T cellsQ34289358
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Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.Q34385843
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Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.Q36223338
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Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimerQ38332364
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.Q39780346
Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapyQ39981758
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Signal transduction by vascular endothelial growth factor receptorsQ84520249
P2507corrigendum / erratumCorrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico InvestigationQ42318042
P4510describes a project that usesImageJQ1659584
P921main subjectin silicoQ192572
P304page(s)48
P577publication date2017-02-06
P1433published inFrontiers in PhysiologyQ2434141
P1476titleInhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
P478volume8

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cites work (P2860)
Q57467572Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides
Q55413755Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat.
Q92642755Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: just What It Takes to Make a Blood Vessel
Q50019794Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions
Q92891221Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma
Q88641629Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature
Q47234112Predictive model identifies strategies to enhance TSP1-mediated apoptosis signaling.
Q39438819Thrombospondins: A Role in Cardiovascular Disease

Q42318042Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigationmain subjectP921

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