Signal transduction by vascular endothelial growth factor receptors

scientific article published on 01 July 2012

Signal transduction by vascular endothelial growth factor receptors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A006502
P932PMC publication ID3385940
P698PubMed publication ID22762016

P50authorLena Claesson-WelshQ4942989
P2093author name stringSina Koch
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Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.Q34451462
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.Q34455428
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeabilityQ34478521
Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cellsQ34496489
Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factorQ34496547
Notch signalling and the regulation of angiogenesisQ34970926
Regulation of vascular permeability by vascular endothelial growth factors.Q35127972
phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial developmentQ35965422
How do endothelial cells orientate?Q35992840
Tyrosine phosphatases in vessel wall signalingQ36017187
Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and developmentQ36074211
Neural guidance molecules regulate vascular remodeling and vessel navigationQ36119408
Integrin signaling is critical for pathological angiogenesisQ36228035
Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissueQ36433516
The role of heparan sulphate proteoglycans in angiogenesisQ36482141
Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cellsQ36615085
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.Q36677542
Bone marrow cells in the 'pre-metastatic niche': within bone and beyondQ36691234
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.Q36693824
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent mannerQ36760948
NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo.Q36775303
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organizationQ36948568
VEGF-A splicing: the key to anti-angiogenic therapeutics?Q37035757
Vascular and epithelial junctions: a barrier for leucocyte migrationQ37117935
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapyQ37135987
Neuropilins: a versatile partner of extracellular molecules that regulate development and diseaseQ37175295
Integrin affinity modulation in angiogenesisQ37179787
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?Q37333639
Phosphoinositide 3-kinases in cell migrationQ37340915
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.Q37599022
VEGFRs and Notch: a dynamic collaboration in vascular patterningQ37631636
Regulation of angiogenesis by ETS transcription factorsQ37631641
Involvement of endothelial progenitor cells in tumor vascularizationQ37677862
Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1).Q37686444
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cellsQ33689582
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesisQ33714947
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulationQ33734632
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.Q33899627
Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexesQ33940345
Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesisQ34019593
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesisQ34022315
Differential expression of neuropilin-1 and neuropilin-2 in arteries and veinsQ34099220
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve developmentQ34162552
Role of ETS family transcription factors in vascular development and angiogenesisQ34246903
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Autocrine VEGF signaling is required for vascular homeostasisQ34443661
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Mapping of the Sites Involved in Ligand Association and Dissociation at the Extracellular Domain of the Kinase Insert Domain-containing Receptor for Vascular Endothelial Growth FactorQ57980717
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartmentQ58035861
Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras ActivationQ58450934
A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation1Q61479346
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alphaQ73150469
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defectQ74215451
Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesisQ79518543
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cellsQ82264553
Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiationQ83177173
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesisQ83296438
C-terminal heparin-binding peptide of snake venom VEGF specifically blocks VEGF-stimulated endothelial cell proliferationQ83365023
Signal transduction by vascular endothelial growth factor receptorsQ84461284
The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cellsQ28216634
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migrationQ28250994
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cellsQ28257153
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growthQ28278074
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formationQ28285842
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cellsQ28363361
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in miceQ28504776
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in miceQ28508807
Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endotheliumQ28512027
Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimerQ28574927
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumQ28587604
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3Q28588628
Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemiaQ28589545
Absence of erythrogenesis and vasculogenesis in Plcg1-deficient miceQ28591776
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growthQ28594005
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesisQ28594191
Focal adhesion kinase: the first ten yearsQ28609173
VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factorQ28646402
VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor bindingQ28646414
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing moleculesQ28646549
Corneal avascularity is due to soluble VEGF receptor-1Q28755125
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF geneQ29547732
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesisQ29614537
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluidQ29617640
Dimerization of VEGF receptors and implications for signal transduction: a computational studyQ30488864
Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesisQ30489396
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell inductionQ30496577
Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergismQ30504482
Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesisQ32061444
Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patternsQ33234980
Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesisQ33553383
Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor actionQ37698859
Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding.Q37716522
The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zetaQ38329456
Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell MigrationQ38349883
Differential expression of neuropilin-1 in malignant and benign prostatic stromal tissue.Q38451455
Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activityQ39709099
Vascular endothelial growth factor B controls endothelial fatty acid uptake.Q39727853
Characterizing the effects of the juxtamembrane domain on vascular endothelial growth factor receptor-2 enzymatic activity, autophosphorylation, and inhibition by axitinib.Q39837884
Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinomaQ39904602
Blocking neuropilin-2 function inhibits tumor cell metastasisQ39994431
The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.Q40193180
Apoptosis of human macrophages by Flt-4 signaling: implications for atherosclerotic plaque pathology.Q40248141
Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancerQ40268215
Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migrationQ40290704
Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptorsQ40427768
Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activityQ40506028
Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarctionQ40643967
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesisQ40713163
Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domainQ40858040
Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligandQ40939852
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutantQ41488146
Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidanceQ41606141
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeabilityQ41714210
Structure of a VEGF-VEGF receptor complex determined by electron microscopyQ41792412
Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sproutingQ41891694
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardiumQ42572244
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cellsQ42815794
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesisQ43072819
VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression.Q43286257
Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal outputQ43435823
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.Q43592482
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophagesQ43664809
A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domainQ43784472
Live imaging of lymphatic development in the zebrafishQ44238801
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sitesQ44526093
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.Q44729061
A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsiaQ45143705
Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.Q45934563
Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesisQ46220745
Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factorQ46693604
Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liverQ46817255
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitmentQ46823868
Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1.Q46843965
Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability.Q47790199
VEGFR-1 signaling regulates the homing of bone marrow-derived cells in a mouse stroke modelQ48340918
Receptors for collapsin/semaphorinsQ48352679
Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.Q51804915
Abnormal lymphatic vessel development in neuropilin 2 mutant mice.Q52114149
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.Q52855186
IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis.Q53618817
VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors.Q54529734
Flt-1 signaling in macrophages promotes glioma growth in vivo.Q55465812
Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesisQ55482573
P433issue7
P304page(s)a006502
P577publication date2012-07-01
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleSignal transduction by vascular endothelial growth factor receptors
P478volume2

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Q33818704Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability
Q38187040Growth factors and early mesoderm morphogenesis: insights from the sea urchin embryo
Q21131825HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice
Q60920093Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma
Q60045624Higher plane of nutrition pre-weaning enhances Holstein calf mammary gland development through alterations in the parenchyma and fat pad transcriptome
Q37731561Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma
Q37501825Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro
Q64065167Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model
Q92343419Hypotensive Snake Venom Components-A Mini-Review
Q52678835Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy.
Q33716420Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation
Q55536886Impact of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) single nucleotide polymorphisms on outcome in gastroenteropancreatic neuroendocrine neoplasms.
Q93015669Impaired Neovascularization in Aging
Q28544931In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis
Q100945794Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model
Q37625434Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
Q49684144Integrated approaches to spatiotemporally directing angiogenesis in host and engineered tissues
Q92999641Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer
Q38088193Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
Q48029881Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion
Q51100722Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery.
Q35877762Joint Effect of Urinary Total Arsenic Level and VEGF-A Genetic Polymorphisms on the Recurrence of Renal Cell Carcinoma
Q38985125KRAS genetic variant as a prognostic factor for recurrence in resectable non-small cell lung cancer
Q47754576Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells.
Q38894472Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells
Q38634403Localization of VEGF to Vascular ECM Is an Important Aspect of Tumor Angiogenesis
Q47147967Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis
Q41718028Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Q92924413Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis
Q35294298Low glucose microenvironment of normal kidney cells stabilizes a subset of messengers involved in angiogenesis.
Q64276542Maternal protein restriction differentially alters the expression of AQP1, AQP9 and VEGFr-2 in the epididymis of rat offspring
Q58132098Mechanical Forces in Tumor Angiogenesis
Q38231224Mechanisms of endothelial cell migration
Q57170602Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review
Q64226777Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury
Q39020269Modulation of VEGF receptor 2 signaling by protein phosphatases
Q50423780Molecular Regulation of Sprouting Angiogenesis
Q26774636Molecular targets for the treatment of pancreatic cancer: Clinical and experimental studies
Q30841236Motor neurons control blood vessel patterning in the developing spinal cord
Q92879135Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression
Q92924530Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis
Q93064139Myoferlin silencing inhibits VEGFR2-mediated proliferation of metastatic clear cell renal cell carcinoma
Q60920540N-acetylcysteine protects hepatocytes from hypoxia-related cell injury
Q90119226NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells
Q38087875Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues
Q41762927Need glucose to sprout: local metabolic control of angiogenesis
Q64891197Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells.
Q89587291Neuropilin: Handyman and Power Broker in the Tumor Microenvironment
Q64275592Neuropilins in the Context of Tumor Vasculature
Q26746028New perspectives in glioblastoma antiangiogenic therapy
Q90246106Nintedanib ameliorates animal model of dermatitis
Q55312849Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.
Q57034613Notch2 signal is required for the maintenance of canine hemangiosarcoma cancer stem cell-like cells
Q38937915Notch: A multi-functional integrating system of microenvironmental signals
Q33842838Novel small peptides derived from VEGF125-136: potential drugs for radioactive diagnosis and therapy in A549 tumor-bearing nude mice
Q33881566Nuclear localization of vascular endothelial growth factor-D and regulation of c-Myc-dependent transcripts in human lung fibroblasts
Q46130631Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Q92634861Oral Delivery of a Tetrameric Tripeptide Inhibitor of VEGFR1 Suppresses Pathological Choroid Neovascularization
Q36327911Ordinary and Activated Bone Grafts: Applied Classification and the Main Features.
Q55470224Outcomes and prognostic factors for aggressive posterior retinopathy of prematurity following initial treatment with intravitreal ranibizumab.
Q41407607Oxidized low-density lipoprotein decreases VEGFR2 expression in HUVECs and impairs angiogenesis
Q47157518P311 Deficiency Leads to Attenuated Angiogenesis in Cutaneous Wound Healing
Q37461467PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
Q42357211PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Q58591190Pathophysiology of Diabetic Retinopathy: The Old and the New
Q92151830Pericytes in Microvessels: From "Mural" Function to Brain and Retina Regeneration
Q44205350Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1.
Q42546627Peroxisome proliferator‑activated receptor γ mediates porcine placental angiogenesis through hypoxia inducible factor‑, vascular endothelial growth factor‑ and angiopoietin‑mediated signaling
Q45071708Placental Growth Factor is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles
Q58778121Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes
Q46037889Podosome rosettes precede vascular sprouts in tumour angiogenesis.
Q38913862Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor
Q28083779Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time
Q37015817Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides
Q50086029Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices
Q38284407Regulation of signaling interactions and receptor endocytosis in growing blood vessels
Q37094060Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
Q35829579Reprogramming energy metabolism and inducing angiogenesis: co-expression of monocarboxylate transporters with VEGF family members in cervical adenocarcinomas.
Q39221209Response of the cerebral vasculature following traumatic brain injury
Q89622533Reverting Immune Suppression to Enhance Cancer Immunotherapy
Q33616384Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis
Q58697249Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway
Q64977643SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model.
Q38804261Semaphorins and their Signaling Mechanisms
Q89762331Simulated Microgravity Influences VEGF, MAPK, and PAM Signaling in Prostate Cancer Cells
Q33620110Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Q47290719Structure-Based Kinase Profiling To Understand the Polypharmacological Behavior of Therapeutic Molecules.
Q91871600Sustain, Adapt, and Overcome-Hypoxia Associated Changes in the Progression of Lymphatic Neoplasia
Q28817495Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown
Q98224544Systems Biology Will Direct Vascular-Targeted Therapy for Obesity
Q45074473Systems Pharmacology of VEGF165b in Peripheral Artery Disease
Q92591242TIPE regulates VEGFR2 expression and promotes angiogenesis in colorectal cancer
Q40219062Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization
Q26781278Targeting RTK Signaling Pathways in Cancer
Q28546317Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro
Q35959083The Association between VEGFR Gene Polymorphisms and Stroke: A Meta-Analysis
Q47136171The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats.
Q91816174The Extraordinary Role of Extracellular RNA in Arteriogenesis, the Growth of Collateral Arteries
Q64978168The Intestinal Lymphatic System: Functions and Metabolic Implications.
Q55078229The Janus Face of VEGF in Stroke.
Q37099065The Lymphatic System in Disease Processes and Cancer Progression
Q50099967The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling
Q37439707The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
Q27030833The Role of Hypoxia-Inducible Factor in Wound Healing
Q91994816The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance
Q94596270The Role of Rho GTPases in VEGF Signaling in Cancer Cells
Q37586773The angiogenic activity of ascites in the course of ovarian cancer as a marker of disease progression
Q26796921The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
Q37210936The delivery of therapeutic oligonucleotides
Q89624349The manifold roles of sialic acid for the biological functions of endothelial glycoproteins
Q35807878The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease
Q60308057The precise molecular signals that control endothelial cell-cell adhesion within the vessel wall
Q54999086The progress of prophylactic treatment in retinopathy of prematurity.
Q42366665The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis.
Q38880066The roles of vascular endothelial growth factor in bone repair and regeneration
Q36192998Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis.
Q64948295Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.
Q90194802Trends and Challenges in Tumor Anti-Angiogenic Therapies
Q26830901Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms
Q64064605Two Birds, One Stone: Double Hits on Tumor Growth and Lymphangiogenesis by Targeting Vascular Endothelial Growth Factor Receptor 3
Q37565593Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells
Q42513534Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Q38219834Understanding the role of Notch in osteosarcoma
Q64104795Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor-induced endothelial progenitor cell proliferation and migration
Q33573324VEGF targets the tumour cell
Q41961850VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration
Q34081464VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions
Q41810895VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Q42271421VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis
Q47137711VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells
Q34480730VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling
Q64277092VEGF/Neuropilin Signaling in Cancer Stem Cells
Q42491822VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications
Q47370649VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2.
Q47100851VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways.
Q40198221VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.
Q47145612VEGFR2 alteration in Alzheimer's disease
Q45318084VEGFR2 mediated cell proliferation
Q51097984VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
Q35031502VEGFR3 does not sustain retinal angiogenesis without VEGFR2
Q55379904Vascular Endothelial Growth Factor B and Its Signaling.
Q36417877Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases
Q38909867Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1.
Q27023354Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair
Q55425447Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
Q60939630Vascular Endothelial Growth Factor, from Basic Research to Clinical Applications
Q38790301Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner.
Q38983079Vascular endothelial growth factor control mechanisms in skeletal growth and repair
Q92671018Vascular endothelial growth factor inhibition and proliferative diabetic retinopathy, a changing treatment paradigm?
Q36387982Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans
Q35517559Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension
Q89182402Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning
Q37345998Vascular endothelial growth factor-A signaling in bone marrow-derived endothelial progenitor cells exposed to hypoxic stress
Q33684215Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cells
Q38882640Vascular endothelial growth factor: a neurovascular target in neurological diseases
Q38418718Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease
Q42377393Vegfa signals through ERK to promote angiogenesis, but not artery differentiation.
Q90047090WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis
Q91675426YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA
Q89929943c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly
Q64051780iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications

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