VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.

scientific article published on 13 October 2015

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. is …
instance of (P31):
scholarly articleQ13442814

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P5530Altmetric DOI10.1111/TRA.12341
P6179Dimensions Publication ID1052094358
P356DOI10.1111/TRA.12341
P953full work available at URLhttp://eprints.whiterose.ac.uk/90882/
P6366Microsoft Academic ID2175236682
P932PMC publication ID4832373
P698PubMed publication ID26459808
P1154Scopus EID2-s2.0-84950152014

P50authorGina SmithQ38801017
Michael HarrisonQ38801036
Sreenivasan PonnambalamQ38801053
Darren C. TomlinsonQ43197540
Stephen WheatcroftQ43402450
Gareth William FearnleyQ56427861
P2093author name stringIzma Abdul-Zani
P2860cites workPossible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokinesQ22010172
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulationQ24306674
AMSH is an endosome-associated ubiquitin isopeptidaseQ24676880
Mechanisms underlying ubiquitinationQ27860656
A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKPQ28138440
Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathwayQ28188326
A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomesQ28245757
Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomesQ28511379
VEGF receptor signalling - in control of vascular functionQ29617256
A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repairQ34472013
Tyrosine Kinase Receptor Flt/VEGFR Family: Its Characterization Related to Angiogenesis and CancerQ34972727
UUCD: a family-based database of ubiquitin and ubiquitin-like conjugationQ36491390
Ubiquitin: Same Molecule, Different Degradation PathwaysQ37812727
Cellular functions of the DUBsQ37987409
Regulation of VEGF signaling by membrane trafficQ38012210
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.Q39780346
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesisQ40713163
Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel FormationQ41921599
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cellsQ42134556
ERBB2 is a target for USP8-mediated deubiquitinationQ42818688
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesisQ43072819
c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic routeQ43700308
Diversity of polyubiquitin chains.Q46040658
Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165.Q46527823
Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells.Q52840587
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.Q52855186
Endothelial cell confluence regulates Weibel-Palade body formation.Q52858151
USP8 controls the trafficking and sorting of lysosomal enzymes.Q54347722
MIT domainiaQ80491571
Signal transduction by vascular endothelial growth factor receptorsQ84461284
Signal transduction by vascular endothelial growth factor receptorsQ84520249
P433issue1
P921main subjectproteolysisQ33123
P304page(s)53-65
P577publication date2015-10-13
P1433published inTrafficQ1572846
P1476titleVEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.
P478volume17

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cites work (P2860)
Q92513343Comparison of the ligand-binding properties of fluorescent VEGF-A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET
Q39685598Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding
Q39074161Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
Q52717006Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.
Q33632000Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations.
Q52654047Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.
Q36257821Release of endothelial cell associated VEGFR2 during TGF-β modulated angiogenesis in vitro
Q58771413SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Q89032142Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma
Q37117319The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation
Q47706180The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways
Q92038158Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions
Q42513534Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Q41810895VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

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