Regulation of VEGF signaling by membrane traffic

scientific article published on 19 May 2012

Regulation of VEGF signaling by membrane traffic is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELLSIG.2012.05.007
P932PMC publication ID5248559
P698PubMed publication ID22617029
P5875ResearchGate publication ID225055776

P2093author name stringArie Horowitz
Himabindu Reddy Seerapu
P2860cites workStabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular developmentQ34108757
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Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factorQ34496547
A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.Q34557341
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Endocytosis and intracellular trafficking of ErbBsQ34827744
PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulationQ35096547
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signalingQ35131603
Urokinase receptor and integrin interactionsQ35181146
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingQ35201347
Growing and shaping the vascular tree: multiple roles for VEGFQ35568152
Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalizationQ35617859
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesisQ35689743
Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signalingQ35770239
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3AQ35848293
Clathrin- and non-clathrin-mediated endocytic regulation of cell signallingQ36028155
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblastsQ36210313
Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinaseQ36235312
Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5aQ36342565
Regulation of membrane traffic by phosphoinositide 3-kinasesQ36391678
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Vesicular trafficking of tyrosine kinase receptors and associated proteins in the regulation of signaling and vascular functionQ36436394
Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1.Q36869441
B-type Eph receptors and ephrins induce growth cone collapse through distinct intracellular pathwaysQ36932964
Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeabilityQ37344103
Systems biology of growth factor-induced receptor endocytosisQ37381801
Endosomes: a legitimate platform for the signaling trainQ37394435
Integrins: masters and slaves of endocytic transport.Q37630929
VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysisQ37631630
The urokinase receptor: focused cell surface proteolysis, cell adhesion and signalingQ37663098
c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1Q37672284
Feedback regulation of EGFR signalling: decision making by early and delayed loops.Q37831109
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Cooperation between integrins and growth factor receptors in signaling and endocytosisQ37887791
The urokinase receptor interactomeQ37895298
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.Q22008760
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalizationQ22009127
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growthQ24293042
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signalingQ24294449
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartmentsQ24299236
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148Q24303092
JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludinQ24306920
Myo6 facilitates the translocation of endocytic vesicles from cell peripheriesQ24307920
FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapseQ24310437
Rab13 mediates the continuous endocytic recycling of occludin to the cell surfaceQ24311646
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosisQ24312776
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targetsQ24313085
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factorQ24321564
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradationQ24323121
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4Q24336334
Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1Q24337418
Sorting nexin 17 facilitates LRP recycling in the early endosomeQ24535575
Integrin ligands at a glanceQ24600618
Eph/ephrin molecules--a hub for signaling and endocytosisQ24611588
Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activityQ24633333
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.Q27331901
Identification and Analysis of Occludin Phosphosites: A Combined Mass Spectrometry and Bioinformatics ApproachQ27653352
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signalingQ27666024
The biology of VEGF and its receptorsQ27860704
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherinQ28116308
Rab GTPases as coordinators of vesicle trafficQ28131746
Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1Q28140309
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesisQ28140788
Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migrationQ28141795
16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cellsQ28143550
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular developmentQ28145776
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion moleculeQ28203316
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylationQ28240025
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cellsQ28257153
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroliginQ28285563
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesisQ28510232
Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesiclesQ28511953
Interactions of GIPC with Dopamine D2, D3but not D4Receptors Define a Novel Mode of Regulation of G Protein-coupled ReceptorsQ28573869
The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)Q28579753
The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veinsQ28590445
Integrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switchQ28732003
Endocytosis and signalling: intertwining molecular networksQ29616848
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradationQ29622825
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pitsQ30159982
Role of Grb2 in EGF-stimulated EGFR internalization.Q30165476
Cell migration is regulated by platelet-derived growth factor receptor endocytosisQ30437225
Genome-wide screen reveals APC-associated RNAs enriched in cell protrusionsQ30437829
Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesisQ30489396
The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts.Q30493646
Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domainQ30494045
Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherinQ33564095
Molecular basis of the core structure of tight junctionsQ33685399
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cellsQ33689582
Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neuronsQ33744718
RAFTK/Pyk2-mediated cellular signallingQ33855347
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptorQ33886791
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesisQ34022315
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migrationQ39963386
The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1.Q39974418
Hrs is a positive regulator of VEGF and insulin signalingQ40143659
The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.Q40193180
Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathwayQ40540331
17 beta -estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk.Q40551077
Platelet-derived growth factor receptor-mediated signal transduction from endosomesQ40609877
Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarctionQ40643967
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesisQ40713163
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431Q40718358
The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling.Q40787511
Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.Q40793167
Identification of isoforms of G proteins and PKC that colocalize with tight junctionsQ41231542
Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.Q41869550
Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathwayQ41927046
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cellsQ42134556
EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.Q42795950
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routingQ42806503
Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis.Q42812672
Dimerization of internalized epidermal growth factor receptorsQ42825202
Protein kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and endothelial cell migrationQ43061421
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesisQ43072819
Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathwaysQ43107632
Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal outputQ43435823
Control of EGF receptor signaling by clathrin-mediated endocytosis.Q45345953
Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migrationQ46626360
C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesisQ47073889
Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surfaceQ47603425
Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability.Q47790199
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cellsQ50336697
Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.Q51804915
Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.Q52541168
The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.Q52845770
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.Q52855186
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartmentQ58035861
Inhibition of fibroblast growth factor receptor 1 endocytosis promotes axonal branching of adult sensory neuronsQ62558017
VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistributionQ63152610
A mechanism for modulation of cellular responses to VEGF: activation of the integrinsQ64380279
Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells.Q64923679
Recycling of epidermal growth factor-receptor complexes in A431 cellsQ69736463
Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomesQ71955066
Dynamics of signaling during insulin-stimulated endocytosis of its receptor in adipocytesQ72391909
Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicleQ72952422
Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2Q80952270
Signal transduction by vascular endothelial growth factor receptorsQ84461284
Endocytosis and signaling: cell logistics shape the eukaryotic cell planQ37980726
Functional interaction of VEGF-C and VEGF-D with neuropilin receptorsQ38311836
Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell MigrationQ38349883
Endosomal dynamics of Met determine signaling outputQ39745537
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.Q39780346
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pitsQ39909110
P433issue9
P1104number of pages11
P304page(s)1810-1820
P577publication date2012-05-19
P1433published inCellular SignallingQ1524097
P1476titleRegulation of VEGF signaling by membrane traffic
P478volume24

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cites work (P2860)
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