VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions

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VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions is …
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scholarly articleQ13442814

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P5530Altmetric DOI10.1091/MBC.E14-05-0962
P6179Dimensions Publication ID1048519243
P356DOI10.1091/MBC.E14-05-0962
P953full work available at URLhttp://eprints.whiterose.ac.uk/80658/
https://doi.org/10.1091/mbc.E14-05-0962
P932PMC publication ID4142621
P698PubMed publication ID24966171
P1154Scopus EID2-s2.0-84905970103

P50authorGareth William FearnleyQ56427861
Sreenivasan PonnambalamQ38801053
Stephen WheatcroftQ43402450
P2093author name stringIan C Zachary
Adam F Odell
Alexander F Bruns
Antony M Latham
Shervanthi Homer-Vanniasinkam
Nicholas J Burgoyne
Nadeem A Mughal
Monica C Hollstein
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Signal transduction by vascular endothelial growth factor receptorsQ84461284
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Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesisQ21089934
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylationQ22254129
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsQ24291278
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growthQ24293042
MSK activation and physiological rolesQ24316998
Cell signaling by receptor tyrosine kinasesQ24598357
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylationQ28240025
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migrationQ28250994
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cellsQ31660362
Decreased immediate inflammatory gene induction in activating transcription factor-2 mutant miceQ31830577
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cellsQ33689582
Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.Q33931625
Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cellsQ33990421
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.Q34111723
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factorsQ34152009
Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.Q34267284
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.Q34452740
Inductive angiocrine signals from sinusoidal endothelium are required for liver regenerationQ34625109
The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cellsQ34988184
p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cellsQ35188461
Role of inflammatory mediators in angiogenesis.Q36048112
ATF2 - at the crossroad of nuclear and cytosolic functionsQ36211955
Anti-VEGF therapies in the clinicQ36330281
Beta1 integrins: zip codes and signaling relay for blood cellsQ36571060
Endothelial signalling events during leukocyte transmigrationQ36586945
The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivoQ36641840
Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesisQ36850583
VEGF-A splicing: the key to anti-angiogenic therapeutics?Q37035757
Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostilityQ37142751
Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancerQ37605234
VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysisQ37631630
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocationQ37822076
Developmental and pathological angiogenesisQ37901035
Endothelial membrane reorganization during leukocyte extravasationQ38008939
Regulation of VEGF signaling by membrane trafficQ38012210
Coordination of VEGF receptor trafficking and signaling by coreceptors.Q38090234
New prospects in the roles of the C-terminal domains of VEGF-A and their cooperation for ligand binding, cellular signaling and vessels formation.Q38319139
Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expressionQ38524223
Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL.Q39699347
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.Q39780346
Vascular endothelial growth factor induces branching morphogenesis/tubulogenesis in renal epithelial cells in a neuropilin-dependent fashionQ40383970
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.Q40402637
VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.Q40595312
Involvement of tyrosine phosphorylation in endothelial adhesion molecule inductionQ41062979
Leukocyte-endothelial adhesion and angiogenesis in tumorsQ41140276
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cellsQ42134556
A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression.Q43871241
VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinomaQ44068637
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potencyQ44317160
VEGF differentially activates STAT3 in microvascular endothelial cellsQ44489900
VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis modelQ46142852
Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165.Q46527823
The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation.Q50319622
Cellular and molecular regulation of vascular permeability.Q50760843
Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells.Q52840587
The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.Q52845770
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.Q52855186
Endothelial cell confluence regulates Weibel-Palade body formation.Q52858151
VEGF189 stimulates endothelial cells proliferation and migration in vitro and up-regulates the expression of Flk-1/KDR mRNA.Q53667872
Vascular endothelial growth factor synergistically enhances induction of E-selectin by tumor necrosis factor-alpha.Q54567111
Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation.Q54610272
P4510describes a project that usesImageJQ1659584
P433issue16
P921main subjectendotheliumQ111140
P304page(s)2509-2521
P577publication date2014-06-25
P1433published inMolecular Biology of the CellQ2338259
P1476titleVEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions
P478volume25

Reverse relations

cites work (P2860)
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Q26796921The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
Q64948295Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.
Q41961850VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration
Q41810895VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Q38418718Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease

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