Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development

scientific article (publication date: September 1999)

Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1097-2765(00)80342-1
P3181OpenCitations bibliographic resource ID1081969
P698PubMed publication ID10518221

P2093author name stringD J Anderson
Z F Chen
H U Wang
S S Gerety
P2860cites workAbnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory gangliaQ29615041
Visualizing an olfactory sensory mapQ29616849
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fateQ29619008
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular developmentQ33633524
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinasesQ34058301
VasculogenesisQ34387300
Antiangiogenic gene therapyQ36069788
Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rateQ36220799
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2Q36223383
ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming SomitesQ36554495
Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart diseaseQ39462155
Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivoQ41168628
Blood vessel formation: what is its molecular basis?Q41288467
Tyrosine phosphorylation of transmembrane ligands for Eph receptorsQ42802862
Signaling Vascular Morphogenesis and MaintenanceQ45058276
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration.Q45967946
Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowthQ46218122
Eph receptors and ephrins restrict cell intermingling and communicationQ48164807
In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrinsQ48195215
The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cellsQ52193318
Angiogenic Therapy of the Human HeartQ55067407
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloningQ24310148
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formationQ24316945
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responsesQ24316974
Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4Q24336334
Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase HtkQ24563938
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisQ24608892
PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle FateQ24683266
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesisQ28286738
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesisQ28287785
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligandsQ28294023
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesisQ28300359
Nuk controls pathfinding of commissural axons in the mammalian central nervous systemQ28507318
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogeneQ28512170
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumQ28587604
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
Mechanisms of angiogenesisQ29547485
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF geneQ29547732
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
circulatory systemQ11068
Eph receptor B4Q21981347
P304page(s)403-14
P577publication date1999-09-01
P1433published inMolecular CellQ3319468
P1476titleSymmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
P478volume4

Reverse relations

cites work (P2860)
Q28510897A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis
Q51923232A genetic screen for mutations that affect cranial nerve development in the mouse.
Q37468040A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development
Q43240696A migratory role for EphrinB ligands in avian epicardial mesothelial cells.
Q47721941A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition
Q40727092A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis
Q47617068ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Q41697025Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow
Q48266279Abnormal blood vessel development in mice lacking presenilin-1.
Q28277857All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos
Q45271793Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations
Q42734618Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy
Q34075013Angiogenesis and chronic kidney disease
Q29614541Angiogenesis in health and disease
Q41828383Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4.
Q30498222Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis
Q35903876Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway
Q34810312Arteries and veins: making a difference with zebrafish
Q28513355Arteriovenous malformations in mice lacking activin receptor-like kinase-1
Q28506090Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis
Q30414333Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy
Q36510991Attenuation of retinal vascular development and neovascularization in PECAM-1-deficient mice
Q37746510Axon guidance molecules in vascular patterning
Q36648644BRG1 promotesCOUP-TFIIexpression and venous specification during embryonic vascular development
Q35937580Blood vessel patterning at the embryonic midline
Q36402724Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseases
Q26765120Building and re-building the heart by cardiomyocyte proliferation
Q36672272Cardiovascular genomics: a current overview of in vivo and in vitro studies
Q27325791Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo
Q38703370Cell type-specific localization of Ephs pairing with ephrin-B2 in the rat postnatal pituitary gland
Q36801092Cell-cell signaling in the neurovascular unit
Q48745802Cellular and molecular mechanisms of embryonic haemangiogenesis and lymphangiogenesis
Q28214281Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues
Q39256747Clinical implications of EphB4 receptor expression in pancreatic cancer
Q36396980Coexistence of EphB1 and EphrinB2 in Port Wine Stain Endothelial Progenitor Cells Contributes to Clinicopathological Vasculature Dilatation.
Q48030369Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers
Q36484515Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers
Q33752236Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis
Q35952161Common cues in vascular and axon guidance
Q34433723Common mechanisms of nerve and blood vessel wiring
Q24290904Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5
Q104510621Comprehensive phenotyping of endothelial cells using flow cytometry 1: Murine
Q35181668Contact-dependent signaling during the late events of platelet activation.
Q39370974Control of blood vessel identity: from embryo to adult.
Q33941577Control of cell behaviour by signalling through Eph receptors and ephrins.
Q34104147Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma
Q91762067Core Element Cloning, Cis-Element Mapping and Serum Regulation of the Human EphB4 Promoter: A Novel TATA-Less Inr/MTE/DPE-Like Regulated Gene
Q30537567Coronary veins determine the pattern of sympathetic innervation in the developing heart
Q54543769Critical role of the axonal guidance cue EphrinB2 in lung growth, angiogenesis, and repair.
Q36844220Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors
Q41579824Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure.
Q30592602Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.
Q38144750Development and pathologies of the arterial wall
Q52113809Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice
Q36489774Differentiation of arterial and venous endothelial cells and vascular morphogenesis
Q30855572Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage
Q37850141Dissection of Cardiovascular Development and Disease Pathways in Zebrafish
Q30581940Distinct Notch signaling outputs pattern the developing arterial system.
Q34872708Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis
Q28506356Dosage-dependent requirement for mouse Vezf1 in vascular system development
Q31813080Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction
Q91893672Dysregulation of the EphrinB2-EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in patients
Q48089344EPHB4 Mutation Implicated in Capillary Malformation-Arteriovenous Malformation Syndrome: A Case Report
Q34129223EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations
Q38951519EPHB4 tyrosine-kinase receptor expression and biological significance in soft tissue sarcoma
Q44636591Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
Q41061677Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α.
Q37046062Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation
Q83226379Endothelial EphB4 maintains vascular integrity and transport function in adult heart
Q36342350Endothelial cells and VEGF in vascular development
Q39699715Endothelial cells regulate cardiomyocyte development from embryonic stem cells
Q38085095Endothelial heterogeneity and adhesion molecules N-glycosylation: implications in leukocyte trafficking in inflammation.
Q44138748Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.
Q85010601Eph family receptors as therapeutic targets
Q29619988Eph receptor signalling casts a wide net on cell behaviour
Q34103639Eph receptors and ephrin ligands: embryogenesis to tumorigenesis
Q38080387Eph receptors and their ligands: Promising molecular biomarkers and therapeutic targets in prostate cancer
Q28677705Eph signaling: a structural view
Q38209232Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics
Q53193478Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase.
Q34681404Eph-B4 prevents venous adaptive remodeling in the adult arterial environment
Q37971902Eph-dependent cell-cell adhesion and segregation in development and cancer.
Q24611588Eph/ephrin molecules--a hub for signaling and endocytosis
Q38436466Eph/ephrin signaling in the kidney and lower urinary tract
Q37120500Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer
Q37951183Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches.
Q38267753EphA3 biology and cancer.
Q48486658EphA4 regulates central nervous system vascular formation
Q30479634EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling
Q35894825EphB3 marks delaminating endocrine progenitor cells in the developing pancreas
Q34747922EphB4 as a therapeutic target in mesothelioma
Q40327178EphB4 controls blood vascular morphogenesis during postnatal angiogenesis
Q34769816EphB4 expression in pterygium is associated with microvessel density
Q35486972EphB4 forward signalling regulates lymphatic valve development
Q35676082EphB4 forward-signaling regulates cardiac progenitor development in mouse ES cells
Q39354035EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target
Q40365399EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival.
Q44390853EphB4 receptor tyrosine kinase transgenic mice develop glomerulopathies reminiscent of aglomerular vascular shunts
Q38972704EphB4 regulates the growth and migration of pancreatic cancer cells
Q37466344EphB4-targeted imaging with antibody h131, h131-F(ab')2 and h131-Fab
Q49709391EphB4: A promising target for upper aerodigestive malignancies
Q42174452Epha3 acts as proangiogenic factor in multiple myeloma
Q33613966Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1.
Q36962774Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment
Q37658786Ephrin expression and function in cancer.
Q39356254Ephrin ligands and Eph receptors contribution to hematopoiesis
Q35536905Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.
Q34536346Ephrin-As as receptors in topographic projections
Q28212190Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction
Q39248946Ephrin-B stimulation of calvarial bone formation.
Q47659849Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats.
Q34022315Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Q30493939Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding.
Q44956263Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development
Q38404246EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown
Q37317736EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.
Q21145780EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment
Q36719255EphrinB2 Reverse Signaling Protects against Capillary Rarefaction and Fibrosis after Kidney Injury
Q57265483EphrinB2 Signalling in Osteoblast Differentiation, Bone Formation and Endochondral Ossification
Q52602937EphrinB2 activation enhances angiogenesis, reduces amyloid-β deposits and secondary damage in thalamus at the early stage after cortical infarction in hypertensive rats
Q35227778EphrinB2 controls vessel pruning through STAT1-JNK3 signalling
Q36959852EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta
Q99211437EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity
Q92020719EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease
Q38842539EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease.
Q34701751Ephs and ephrins close ranks
Q44569763Ephs and ephrins during early stages of chick embryogenesis
Q28586276Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis
Q34031959Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis
Q33264945Expression of ephrin in retinal neovascularization and iris rubeosis
Q42444483Fluid shear stress induces arterial differentiation of endothelial progenitor cells
Q36103385Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice
Q64054528Functional characterization of iPSC-derived arterial- and venous-like endothelial cells
Q84514621Generation of transgenic mice overexpressing EfnB2 in endothelial cells
Q36379514Genetic and epigenetic mechanisms in the early development of the vascular system
Q37467785Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance
Q35568152Growing and shaping the vascular tree: multiple roles for VEGF
Q57072959Guidance Molecules in Vascular Smooth Muscle
Q50696862HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia
Q37594746Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
Q28505269Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Q39004714Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs
Q30482359Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice
Q43119202Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development
Q54593908High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.
Q33511250Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes
Q64270938Hypoxia promotes differentiation of adipose-derived stem cells into endothelial cells through demethylation of ephrinB2
Q54338851Increased EphB2 expression predicts cholangiocarcinoma metastasis
Q92321643Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Q35828791Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
Q90123314Inhibition of erythropoietin-producing hepatoma receptor B4 (EphB4) signaling suppresses the vascularization and growth of endometriotic lesions
Q27664544Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors
Q24534800Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred
Q37994636Intercellular cross-talk among bone cells: new factors and pathways.
Q47105284Intraluminal valves: development, function and disease.
Q33651585Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
Q34428794Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells
Q46862943KLF2 transcription factor modulates blood vessel maturation through smooth muscle cell migration
Q38765961KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors
Q31965129Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.
Q37971729Life is a pattern: vascular assembly within the embryo
Q24301313Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway
Q28506951Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor
Q35743851Manipulating angiogenesis in medicine
Q28208291Mechanisms and functions of Eph and ephrin signalling
Q35962939Mechanisms and regulation of lung vascular development
Q38704281Mechanisms of ephrin-Eph signalling in development, physiology and disease.
Q37509308Microvascular pericytes in healthy and diseased kidneys
Q84736698Molecular Mechanisms of Tumor Angiogenesis
Q35551132Molecular basis of angiogenesis and cancer
Q35066914Molecular control of arterial-venous blood vessel identity
Q37593631Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals
Q36766808Molecular mechanisms of pulmonary vascular development
Q35564001Motor axon migration: a long way to go
Q28304868Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system
Q28205325Multiple roles of EPH receptors and ephrins in neural development
Q41337528Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer.
Q34014661Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart
Q38087875Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues
Q36264747Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature
Q38085110New Insights into the Developmental Mechanisms of Coronary Vessels and Epicardium
Q54624593New vandetanib analogs: fused tricyclic quinazolines with antiangiogenic potential.
Q35252574Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis
Q29620377Notch signaling is essential for vascular morphogenesis in mice
Q24299001Notch signaling is essential for ventricular chamber development
Q30493962Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants
Q35591804Notch1 is pan-endothelial at the onset of flow and regulated by flow.
Q41761841Notch4 normalization reduces blood vessel size in arteriovenous malformations
Q33745300Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth
Q37681157Novel aspects of corneal angiogenic and lymphangiogenic privilege.
Q28479031Novel strategy for selection of monoclonal antibodies against highly conserved antigens: phage library panning against ephrin-B2 displayed on yeast
Q36108192Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation
Q37657570Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype
Q34032032Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF).
Q45232514Overexpression of EphB4, EphrinB2, and epidermal growth factor receptor in papillary thyroid carcinoma: A pilot study
Q49804818Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments.
Q28506962Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
Q28585965PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
Q35785713PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
Q35018094Plumbing the mysteries of vascular development using the zebrafish
Q37345639Possible novel targets for therapeutic angiogenesis
Q35750148Proangiogenic role of ephrinB1/EphB1 in basic fibroblast growth factor-induced corneal angiogenesis
Q64111876Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish
Q33872553RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity
Q92656933RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development
Q34230386Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
Q35825299Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma
Q24798176Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer
Q35221906Receptor tyrosine kinase EphB4 is a survival factor in breast cancer
Q36763861Reduced adult endothelial cell EphB4 function promotes venous remodeling.
Q34382591Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency
Q38012210Regulation of VEGF signaling by membrane traffic
Q38284407Regulation of signaling interactions and receptor endocytosis in growing blood vessels
Q36765650Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases.
Q38386097Renal endothelial injury and microvascular dysfunction in acute kidney injury
Q36680080Ribozyme technology for cancer gene target identification and validation
Q46465346Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity.
Q54238065Role of EFNB2/EPHB4 signaling in spiral artery development during pregnancy: An appraisal
Q89052192Role of Endothelial-to-Mesenchymal Transition in the Pathogenesis of Central Nervous System Hemangioblastomas
Q26860972Role of Eph/ephrin tyrosine kinase in malignant glioma
Q38201075Role of ROBO4 signalling in developmental and pathological angiogenesis
Q44589906Role of ephrin B2 in human retinal endothelial cell proliferation and migration
Q51966746SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.
Q35025018Sema3D and Sema7A have distinct expression patterns in chick embryonic development
Q35583161Sema3D, Sema3F, and Sema5A are expressed in overlapping and distinct patterns in chick embryonic heart
Q46623662Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin
Q37898063Signal transduction in vasculogenesis and developmental angiogenesis
Q28210262Signals from Eph and ephrin proteins: a developmental tool kit
Q28204868Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature
Q36976443Similarities between angiogenesis and neural development: what small animal models can tell us.
Q36784413Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification
Q44172489Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.
Q37185221Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells
Q38416404Spatiotemporal mapping of vascularization and innervation in the fetal murine intestine.
Q30896811Specialization of tumour vasculature
Q33973350Specification of arterial, venous, and lymphatic endothelial cells during embryonic development
Q35925849Structures of axon guidance molecules and their neuronal receptors
Q37141121Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries
Q28509237Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
Q36518309Targeting the EphB4 Receptor for Cancer Diagnosis and Therapy Monitoring
Q52692067The Blood-Brain Barrier and the EphR/Ephrin System: Perspectives on a Link Between Neurovascular and Neuropsychiatric Disorders
Q38006838The Eph/Ephrin family in cancer metastasis: communication at the service of invasion
Q35832019The aortic ring model of angiogenesis: a quarter century of search and discovery
Q38090418The cell-matrix interface: a possible target for treating retinal vascular related pathologies
Q37947082The cytochrome P450 pathway in angiogenesis and endothelial cell biology.
Q31859070The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration.
Q34078717The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder
Q46699319The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
Q28212424The ephrins and Eph receptors in angiogenesis
Q26770162The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
Q38215321The functional diversity of essential genes required for mammalian cardiac development.
Q35299351The impact of anti-angiogenic agents on cancer therapy
Q37946049The initiation of blood flow and flow induced events in early vascular development
Q33336877The molecular phylogeny of eph receptors and ephrin ligands
Q28088632The molecular regulation of arteriovenous specification and maintenance
Q38031457The murine allantois: a model system for the study of blood vessel formation
Q44216042The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Q36052725The neurovascular unit and its growth factors: coordinated response in the vascular and nervous systems.
Q50079573The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis
Q36610209The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome
Q38609464The role of Eph/ephrin molecules in stromal–hematopoietic interactions
Q37039134The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade
Q33677805The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
Q35849505The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
Q38174793Therapeutic targeting of EPH receptors and their ligands
Q92185709Tie2 regulates endocardial sprouting and myocardial trabeculation
Q37304957Tissue-engineered vascular grafts demonstrate evidence of growth and development when implanted in a juvenile animal model
Q37097453Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature.
Q37188074Transgenic mouse models of angiogenesis and lymphangiogenesis
Q28593395Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis
Q43559492Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism.
Q84543407VEGF and ephrin-B2: a bloody duo
Q38047482Vascular contributions to early ovarian development: potential roles of VEGFA isoforms
Q38246267Vascular development and hemodynamic force in the mouse yolk sac.
Q52165379Vascular developmental biology: getting nervous
Q35855622Vascular endothelial growth factor and other signaling pathways in developmental and pathologic angiogenesis
Q36867965Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells.
Q29614780Vascular-specific growth factors and blood vessel formation
Q64931798Vasculogenesis drives pulmonary vascular growth in the developing chick embryo
Q61443332Venous identity requires BMP signalling through ALK3
Q34087706Vessel Arterial-Venous Plasticity in Adult Neovascularization
Q34119813Whole-Mount Confocal Microscopy for Vascular Branching Morphogenesis
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