Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment

scientific article published on 25 March 2010

Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPGI.00510.2009
P932PMC publication ID3695393
P698PubMed publication ID20338920
P5875ResearchGate publication ID42589044

P50authorAmitava DasQ41909417
P2093author name stringDebabrata Mukhopadhyay
Raul Urrutia
Uday Shergill
Vijay H Shah
Lokendra Thakur
Sutapa Sinha
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Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular developmentQ28145776
Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblastsQ28234993
The Eph family of receptorsQ28251298
A novel putative tyrosine kinase receptor encoded by the eph geneQ28280591
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Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosisQ28582038
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient MiceQ29615196
Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and functionQ30485959
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.Q30488268
Reactive oxygen species stimulate VEGF production from C(2)C(12) skeletal myotubes through a PI3K/Akt pathway.Q32127779
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalitiesQ33491173
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Q33491174
Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinomaQ34085434
Eph receptors and ephrin ligands: embryogenesis to tumorigenesisQ34103639
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2Q34195975
Pericytes: cell biology and pathologyQ34243347
Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.Q34577470
Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblastsQ35083913
Hepatic stellate cells: unique characteristics in cell biology and phenotypeQ35155027
EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasisQ35194872
Angiogenesis in chronic inflammatory liver diseaseQ35762577
Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosisQ35788316
Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte?Q36746579
Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescenceQ37224985
Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoidsQ37375931
Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth.Q39674949
Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.Q40068184
Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasisQ40668665
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assemblyQ42168707
Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic functionQ42474496
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional elementQ42834668
Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.Q44138748
Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.Q46009203
KLF2 transcription factor modulates blood vessel maturation through smooth muscle cell migrationQ46862943
Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liverQ47993681
Endothelial activation and circulating vascular adhesion molecules in alcoholic liver diseaseQ71612600
P433issue6
P921main subjectendotheliumQ111140
P304page(s)G908-15
P577publication date2010-03-25
P1433published inAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyQ15765756
P1476titleEphrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment
P478volume298

Reverse relations

cites work (P2860)
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Q34373533Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis

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