Insights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis

scientific article (publication date: February 2002)

Insights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9440(10)64884-5
P8608Fatcat IDrelease_kr7el3bemva27ghmi3ry2gmqwe
P932PMC publication ID1850631
P698PubMed publication ID11839585

P50authorMark D. GorrellQ38799589
Catherine Anne AbbottQ39188539
Geoffrey W McCaughanQ93355454
Nicholas A ShackelQ115135167
P2093author name stringPeter H McGuinness
P2860cites workCloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epitheliumQ22009003
Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liverQ22010826
Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumorsQ24309604
SARPs: a family of secreted apoptosis-related proteinsQ24311564
Signal transduction by the Wnt family of ligandsQ24530639
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactionsQ24564834
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptorsQ24569584
Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramersQ27485114
Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis modelQ28142724
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducerQ28286663
The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamilyQ28304981
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic miceQ29620765
Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis CQ29620791
Options available--from start to finish--for obtaining expression data by microarray.Q31920702
The role of hepatitis C virus in hepatocellular carcinomaQ33534995
DNA microarray technology: the anticipated impact on the study of human diseaseQ33600666
Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence.Q33720363
Apoptosis and pathogenesis of viral hepatitis C--an updateQ33886610
Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance.Q33916624
Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infectionQ35358973
Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expressionQ35365390
Cellular and molecular mechanisms of hepatocarcinogenesisQ35532421
Profiling of differentially expressed genes in human primary cervical cancer by complementary DNA expression arrayQ38330139
Co-localisation of insulin-like growth factor II and the proliferation marker MIB1 in hepatocellular carcinoma cellsQ38475539
Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIB1 Ki67 in archival material: the role of etiology, disease activity, iron, and lipid peroxidationQ38477912
Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokinesQ38506378
Expression of connective tissue growth factor in experimental rat and human liver fibrosisQ40926848
Cell surface immunophenotype and gelatinase activity of the human breast carcinoma cell line (MCF-7/6) with functionally defective E-cadherin.Q40950970
Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38.Q40983568
Wnt signalling goes nuclearQ41359112
Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizerQ41842388
CXCR4 mRNA expression in colon, esophageal and gastric cancers and hepatitis C infected liver.Q42993011
c-erbB-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinomaQ43526977
Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I.Q43623003
The role of TGFbeta1 in initiating hepatic stellate cell activation in vivoQ44383140
Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections.Q45765597
Insulin regulates heregulin binding and ErbB3 expression in rat hepatocytesQ46371284
Interleukin-8 and hIRH (SDF1-alpha/PBSF) mRNA expression and histological activity index in patients with chronic hepatitis C.Q47872924
Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinomaQ47912418
Application of the differential hybridization of Atlas Human expression arrays technique in the identification of differentially expressed genes in human glioblastoma multiforme tumor tissueQ48473627
Expression of vascular endothelial growth factor in normal liver and hepatocellular carcinoma: an immunohistochemical study.Q50950759
A DNA chip off the aging block.Q51604342
Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts -3A, -5A, or -11.Q52193425
Fas system and apoptosis in viral hepatitis.Q53961575
cDNA expression array reveals heterogeneous gene expression profiles in three glioblastoma cell lines.Q55476928
Oncostatin M: a cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cellsQ60537831
Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosisQ60617867
Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinomasQ71173348
Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factorQ71381389
Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cellsQ71818782
Histological patterns of prolonged hepatitis C infectionQ72898849
Pathogenesis of liver fibrosisQ73129364
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesisQ73136433
Differential gene expression between chronic hepatitis B and C hepatic lesionQ73570992
Characterization and regulation of insulin-like growth factor binding proteins in human hepatic stellate cellsQ74038832
Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinomaQ74093462
Characterization of the IGF axis components in isolated rat hepatic stellate cellsQ74530388
Serum levels of soluble Fas antigen in chronic hepatitis C patientsQ77585915
Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cellsQ77598562
T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen densityQ77756341
Chronically elevated proliferation as a risk factor for neoplasiaQ77783869
Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cellsQ93890819
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
liver cirrhosisQ147778
hepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)641-54
P577publication date2002-02-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleInsights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis
P478volume160

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cites work (P2860)
Q35749152Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
Q38376179Activation of Type I and Type III Interferons in Chronic Hepatitis C.
Q36551170Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients
Q37607343Advances in viral hepatitis: 50 years of Australian gastroenterology
Q46169180An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis
Q42984532Analysis of gene transcription in sera during chronic hepatitis C infection.
Q35762577Angiogenesis in chronic inflammatory liver disease
Q36436755Angiogenic cell therapy for hepatic fibrosis
Q94314421Association between Hepatitis C Virus Infection, p53 Phenotypes, and Gene Variants of Adenomatous Polyposis Coli in Hepatocellular Carcinomas
Q36067494Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA microarray
Q37409999Basic concepts of microarrays and potential applications in clinical microbiology
Q91767797CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury
Q53661342CD147 renal expression as a biomarker for progressive IgAN.
Q45396613Changes in intrahepatic gene expression profiles from chronic hepatitis to hepatocellular carcinoma in patients with hepatitis C virus infection
Q38157936Chronic HCV infection and inflammation: Clinical impact on hepatic and extra-hepatic manifestations
Q47411490Comparison of the expression of beta-catenin in hepatocellular carcinoma in areas with high and low levels of exposure to aflatoxin B1.
Q50075361Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease
Q94593890Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Q37719732Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics
Q24682975Dealing with the family: CD147 interactions with cyclophilins
Q37261192Differences in gene expression profiles from asbestos-treated SPARC-null and wild-type mouse lungs
Q40221690Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis.
Q37006700Differentially regulated gene expression associated with hepatitis C virus clearance
Q35453802Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus
Q34760613Discoidin domain receptor 1: isoform expression and potential functions in cirrhotic human liver.
Q47387960Disease- and cell-specific expression of GP73 in human liver disease
Q46843790Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
Q33832050ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver
Q37057685Emmprin and KSHV: new partners in viral cancer pathogenesis.
Q36962774Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment
Q39018781Expression and clinical implications of HAb18G/CD147 in hepatocellular carcinoma
Q54776431Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid.
Q40370679Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line
Q35666213Fibrosis progression in chronic hepatitis C virus infection
Q35945962Gene expression profiling of HCV genotype 3a initial liver fibrosis and cirrhosis patients using microarray
Q35843317Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver
Q38323133Gene network profiling before and after transplantation in alcoholic cirrhosis liver transplant recipients
Q44804223Gene profiling of early and advanced liver disease in chronic hepatitis C patients
Q80353336Genetics of hepatocellular carcinoma
Q64105965Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells
Q27488251HCV Tumor Promoting Effect Is Dependent on Host Genetic Background
Q33946682Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation
Q29616840Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
Q38337047Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses
Q39563323Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer
Q31126487Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis
Q36749431Hepatitis C virus infection--pathobiology and implications for new therapeutic options
Q34974042Hepatitis C virus virology and new treatment targets
Q36561567Hepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategies
Q35373019Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis.
Q33976028Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis
Q40211269Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C.
Q37997024Innate immunity and hepatitis C virus infection: a microarray's view
Q36160709Insulin resistance and steatosis in hepatitis C virus infection.
Q37788976Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis.
Q35994924Interferon alpha and T-cell responses in chronic myeloid leukemia
Q34328120Interferon type I gene expression in chronic hepatitis C.
Q43692671Interferon-alpha therapy does not modulate hepatic expression of classical type I interferon inducible genes
Q35078322Interferon-λ4 (IFNL4) transcript expression in human liver tissue samples
Q27335708Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis
Q33959178Molecular mechanisms involved in the interaction effects of alcohol and hepatitis C virus in liver cirrhosis.
Q35196596Molecular viral oncology of hepatocellular carcinoma
Q26851211Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development
Q61895898Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C
Q46000902Overexpression of beta-catenin is responsible for the development of portal hypertension during liver cirrhosis.
Q34936128Pathogenesis of hepatitis C virus recurrence in the liver allograft
Q35046563Pathogenic interactions between alcohol and hepatitis C.
Q34794004Plasma fibroblast growth factor 23 concentration is increased and predicts mortality in patients on the liver-transplant waiting list.
Q51841156Renal allografts with IF/TA display distinct expression profiles of metzincins and related genes.
Q40371810Role for hedgehog signaling in hepatic stellate cell activation and viability
Q37228554Role of emmprin/CD147 in tissue remodeling.
Q38304391Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients
Q54792449SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates.
Q24318809Sensing extracellular matrix: an update on discoidin domain receptor function
Q35078725TP53 and liver carcinogenesis.
Q36777331TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer
Q37978104Targeting fibroblast growth factor receptor signaling in hepatocellular carcinoma
Q33578091The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis
Q27008819The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair
Q36647336The hepatic transcriptome in human liver disease
Q36812745Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer
Q90382694δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients