Targeting fibroblast growth factor receptor signaling in hepatocellular carcinoma

scientific article published on January 2011

Targeting fibroblast growth factor receptor signaling in hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1159/000335472
P698PubMed publication ID22269894

P50authorAnn-Lii ChengQ38639483
P2093author name stringAndrew X Zhu
Ying-Chun Shen
P2860cites workSignaling via fibroblast growth factor receptor-1 is dependent on extracellular matrix in capillary endothelial cell differentiationQ40964458
E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical modelsQ42816147
The Significance of Fibroblast Growth Factor Receptor 2 Expression in Differentiation of Hepatocellular CarcinomaQ43451322
Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation.Q44934094
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic interventionQ45254446
A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumorsQ46669648
Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.Q53331692
Plasma level of basic fibroblast growth factor increases with progression of chronic liver disease.Q53446253
Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis.Q53578148
Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma.Q54669173
A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma.Q54681050
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyQ24676527
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient miceQ24684986
A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic miceQ24685118
Insights into the Pathobiology of Hepatitis C Virus-Associated CirrhosisQ27478238
Management of hepatocellular carcinoma: An updateQ27860530
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targetsQ28303698
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lungQ28591023
Liver fibrosisQ29547449
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsQ29615445
Fibroblast growth factor signalling: from development to cancerQ29616827
Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancerQ33397708
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activationQ33648263
Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors.Q34089525
FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of miceQ34172882
Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosisQ34223462
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screeningQ34701235
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinomaQ34842280
A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumorsQ35116704
Role of Fibroblast Growth Factor Type 1 and 2 in Carbon Tetrachloride-Induced Hepatic Injury and FibrogenesisQ35792203
Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinomaQ36213899
Hepatocellular carcinoma. A worldwide problem and the major risk factorsQ36401904
Large induction of keratinocyte growth factor expression in the dermis during wound healingQ37126541
Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005.Q37157400
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinomaQ37847011
Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissuesQ38474392
Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis.Q39592731
Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivoQ39623814
The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.Q39747642
P433issue5-6
P304page(s)372-380
P577publication date2011-01-01
P1433published inOncologyQ2016300
P1476titleTargeting fibroblast growth factor receptor signaling in hepatocellular carcinoma
P478volume81

Reverse relations

cites work (P2860)
Q24658608(125)I-labeled anti-bFGF monoclonal antibody inhibits growth of hepatocellular carcinoma
Q33440392A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma.
Q44607425A needle in a haystack: Identifying biomarkers to personalize systemic therapy in patients with hepatocellular carcinoma
Q54976445A novel association between core mutations in hepatitis B virus genotype F1b and hepatocellular carcinoma in Alaskan Native People.
Q47890330A possible role of microRNAs as predictive markers for the recurrence of hepatocellular carcinoma after liver transplantation
Q89250918Angiogenesis and Hepatic Fibrosis: Western and Chinese Medicine Therapies on the Road
Q95276807Angiogenesis in Hepatocellular Carcinoma; Pathophysiology, Targeted Therapy, and Role of Imaging
Q34525925Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
Q38923517Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma
Q38974755Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.
Q92980089Fibroblast growth factor signaling in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Paving the way to hepatocellular carcinoma
Q98288232Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients
Q26771518Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step
Q58731797Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression
Q35922102Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo
Q33751398Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?
Q35913384Liver cancer oncogenomics: opportunities and dilemmas for clinical applications
Q38197503Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells
Q41166121Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma
Q37031712Sorafenib in advanced hepatocellular carcinoma: current status and future perspectives
Q47266310Targeting tumor-infiltrating Ly6G+ myeloid cells improves sorafenib efficacy in mouse orthotopic hepatocellular carcinoma
Q33275125The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival

Search more.