Role of ROBO4 signalling in developmental and pathological angiogenesis

scientific article published on 06 February 2014

Role of ROBO4 signalling in developmental and pathological angiogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2014/683025
P932PMC publication ID3933320
P698PubMed publication ID24689049
P5875ResearchGate publication ID261258452

P50authorGopeshwar NarayanQ85940791
Suresh Singh YadavQ89172318
P2860cites workSlit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidanceQ22009125
Dll4, a novel Notch ligand expressed in arterial endotheliumQ22254193
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factorsQ24291136
WIP regulates N-WASP-mediated actin polymerization and filopodium formationQ24291191
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complexQ24291871
roundabout4 is essential for angiogenesis in vivoQ24300621
Magic roundabout, a tumor endothelial marker: expression and signalingQ24302083
A molecular mechanism for the heparan sulfate dependence of slit-robo signalingQ24308849
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activityQ24310601
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeabilityQ24311667
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5BQ24311684
Repulsive axon guidance molecule Slit3 is a novel angiogenic factorQ24315030
The axonal repellent, Slit2, inhibits directional migration of circulating neutrophilsQ24316445
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth FactorQ24321564
Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptorsQ24336174
Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4Q24336334
Robo1 and Robo2 are homophilic binding molecules that promote axonal growthQ24337777
SLIT2-mediated ROBO2 signaling restricts kidney induction to a single siteQ24338774
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsionQ24555752
Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of SlitQ24561363
Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axonsQ24562721
Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila RoboQ27650132
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherinQ28116308
Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axonsQ28140210
The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidanceQ28141216
Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesisQ28144856
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular developmentQ28145776
Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activityQ28191245
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathwayQ28201752
Robo4 is a vascular-specific receptor that inhibits endothelial migrationQ28203755
Quantification of expression of netrins, slits and their receptors in human prostate tumorsQ28216890
Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in miceQ28506236
Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesisQ28511809
Notch signaling is essential for vascular morphogenesis in miceQ29620377
SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivoQ30563310
Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5BQ57580153
Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migrationQ80865997
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafishQ33292068
Silencing of directional migration in roundabout4 knockdown endothelial cellsQ33382276
Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.Q33574529
Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factorsQ33724317
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenzaQ33875118
Vascular Robo4 restricts proangiogenic VEGF signaling in breastQ33934735
Switching repulsion to attraction: changing responses to slit during transition in mesoderm migrationQ33944483
Common mechanisms of nerve and blood vessel wiringQ34433723
A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endotheliumQ34627363
Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progressionQ34695790
MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16/F10 mouse melanoma modelQ34731745
The role of neuropilin in vascular and tumor biology.Q35076249
Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafishQ35182957
Blood vessels and nerves: common signals, pathways and diseasesQ35209976
Novel angiogenic signaling pathways and vascular targetsQ35639130
Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxiaQ35918271
Role of neural guidance signals in blood vessel navigationQ36017211
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2Q36082465
Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cellsQ36526659
A Roundabout Way to CancerQ38010295
Slit2-Robo signaling: a novel regulator of vascular injuryQ38111986
Favorable prognosis of operable non-small cell lung cancer (NSCLC) patients harboring an increased expression of tumor endothelial markers (TEMs)Q39153671
Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial markerQ39969499
Syndapin oligomers interconnect the machineries for endocytic vesicle formation and actin polymerization.Q40304282
Robo4 signaling in endothelial cells implies attraction guidance mechanisms.Q40315763
HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinomaQ40655023
Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activityQ41967564
Frequent epigenetic inactivation of the SLIT2 gene in gliomasQ44526180
cAMP-induced switching in turning direction of nerve growth cones.Q46280291
Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesisQ46804013
The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.Q48750095
Slit-Robo: a potential way to treat periodontitisQ49207423
P3931copyright holdergroup of authorsQ1690980
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
angiogenesisQ539568
signal transductionQ828130
neovascularizationQ1281049
cell surface receptorQ2476074
roundabout protein familyQ7371221
physiologic neovascularizationQ105299511
P304page(s)683025
P577publication date2014-02-06
P13046publication type of scholarly workreview articleQ7318358
P1433published inBioMed Research InternationalQ17509958
P1476titleRole of ROBO4 signalling in developmental and pathological angiogenesis
P478volume2014

Reverse relations

cites work (P2860)
Q37499310A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity.
Q35187503Induction of tumor inhibitory anti-angiogenic response through immunization with interferon Gamma primed placental endothelial cells: ValloVax™.
Q38304820Lipid rafts: integrated platforms for vascular organization offering therapeutic opportunities
Q90543488NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
Q58801313Nitric oxide deficiency and endothelial-mesenchymal transition of pulmonary endothelium in the progression of 4T1 metastatic breast cancer in mice
Q38640436Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations
Q88547137Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth
Q60922843Robo 4 - the double-edged sword in prostate cancer: impact on cancer cell aggressiveness and tumor vasculature
Q92651117Structure and Function of Roundabout Receptors
Q37439707The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
Q26775454The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers

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