scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0960-9822(01)00506-1 |
P8608 | Fatcat ID | release_phi6u3z4jndiropky3vnpipdhi |
P953 | full work available online at | http://www.cell.com/article/S0960982201005061/pdf |
https://api.elsevier.com/content/article/PII:S0960982201005061?httpAccept=text/plain | ||
https://api.elsevier.com/content/article/PII:S0960982201005061?httpAccept=text/xml | ||
P698 | PubMed publication ID | 11696321 |
P5875 | ResearchGate publication ID | 11658731 |
P50 | author | Ingrid Jordens | Q62131463 |
P2093 | author name string | A. Hall | |
J. Vandekerckhove | |||
K. Gevaert | |||
M. Driessens | |||
S. Krugmann | |||
P2860 | cites work | Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1 | Q22009908 |
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein | Q22253357 | ||
Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog | Q43634386 | ||
Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase | Q46202539 | ||
Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates. | Q54621778 | ||
Yeast two-hybrid system to detect protein-protein interactions with Rho GTPases. | Q54621797 | ||
16-BAC/SDS–PAGE: A Two-Dimensional Gel Electrophoresis System Suitable for the Separation of Integral Membrane Proteins | Q55870012 | ||
Rho GTPases and their effector proteins | Q56690400 | ||
Negative regulation of fibroblast motility by Ena/VASP proteins | Q73990271 | ||
Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation | Q77342941 | ||
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling | Q24290667 | ||
Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin | Q24290738 | ||
WIP regulates N-WASP-mediated actin polymerization and filopodium formation | Q24291191 | ||
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases | Q24304128 | ||
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization | Q24309118 | ||
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP | Q24318478 | ||
A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family | Q24532768 | ||
The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments | Q24653380 | ||
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia | Q24682164 | ||
Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes | Q24685793 | ||
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch | Q27626911 | ||
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors | Q27860467 | ||
Rho GTPases and the Actin Cytoskeleton | Q27860579 | ||
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling | Q27861063 | ||
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia | Q27861126 | ||
The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation | Q28141490 | ||
The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses | Q28142887 | ||
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains | Q28143912 | ||
The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of DrosophilaEnabled | Q28257310 | ||
Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1 | Q28273496 | ||
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex | Q28293934 | ||
Mena is required for neurulation and commissure formation | Q28588447 | ||
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics | Q28590972 | ||
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate | Q28647599 | ||
Rho GTPases and their effector proteins | Q29547740 | ||
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts | Q29614253 | ||
Directed actin polymerization is the driving force for epithelial cell-cell adhesion | Q29618861 | ||
Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled | Q30176335 | ||
The clutch hypothesis revisited: ascribing the roles of actin-associated proteins in filopodial protrusion in the nerve growth cone | Q30898670 | ||
A peptide concentration and purification method for protein characterization in the subpicomole range using matrix assisted laser desorption/ionization‐postsource decay (MALDI‐PSD) sequencing | Q32060245 | ||
Peptides adsorbed on reverse‐phase chromatographic beads as targets for femtomole sequencing by post‐source decay matrix assisted laser desorption ionization‐reflectron time of flight mass spectrometry (MALDI‐RETOF‐MS) | Q32092387 | ||
Flipping the switch: the structural basis for signaling through the CRIB motif | Q34019126 | ||
P433 | issue | 21 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | identical protein binding | Q14762994 |
BAR/IMD domain containing adaptor protein 2 | Q21171687 | ||
ENAH actin regulator | Q21497088 | ||
cytoskeletal proteins | Q66563066 | ||
P304 | page(s) | 1645-55 | |
P577 | publication date | 2001-10-30 | |
P1433 | published in | Current Biology | Q1144851 |
P1476 | title | Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex | |
P478 | volume | 11 |
Q92130361 | A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension |
Q30658198 | A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis |
Q37622579 | A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease |
Q24306756 | A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein |
Q50075772 | ADP-ribosylation factor-like 4C binding to filamin-A modulates filopodium formation and cell migration |
Q33292441 | Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1 |
Q28116257 | Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation |
Q50495381 | Actin Filament Structures in Migrating Cells. |
Q33724317 | Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors |
Q50513586 | Aquaporin 9 phosphorylation mediates membrane localization and neutrophil polarization |
Q24603149 | Arp2/3 complex is required for actin polymerization during platelet shape change |
Q38284607 | BAR domain proteins regulate Rho GTPase signaling |
Q93231136 | BAR domain proteins-a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton |
Q37883261 | Barfly: Sculpting membranes at the Drosophila neuromuscular junction |
Q40219478 | Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis |
Q106519006 | CDC42 binds effectors at the plasma membrane |
Q24337450 | CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP |
Q24297080 | Cdc42 Interaction with N-WASP and Toca-1 Regulates Membrane Tubulation, Vesicle Formation and Vesicle Motility: Implications for Endocytosis |
Q28566710 | Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells |
Q42135654 | Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination |
Q55312765 | Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. |
Q38941236 | Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome |
Q38006770 | Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT) |
Q42240156 | Control of Rho GTPase function by BAR-domains |
Q38120723 | Control of actin filament dynamics at barbed ends by WH2 domains: From capping to permissive and processive assembly |
Q27677946 | Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair |
Q33455812 | Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion |
Q30476018 | Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration |
Q43003185 | Direct interaction of beta-dystroglycan with F-actin |
Q28188673 | Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42 |
Q47969128 | Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays |
Q35132220 | Do filopodia enable the growth cone to find its way? |
Q34495189 | Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration |
Q46404333 | Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa |
Q28391837 | Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo |
Q35239591 | Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons |
Q38257347 | Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins. |
Q30586599 | Dynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics |
Q33564094 | Electron tomography reveals unbranched networks of actin filaments in lamellipodia |
Q63364715 | Embryo Morphogenesis and the Role of the Actin Cytoskeleton |
Q39611596 | Emerging roles of focal adhesion kinase in cancer |
Q30476860 | Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts |
Q46133242 | Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. |
Q38348001 | Epithelial morphogenesis: the mouse eye as a model system |
Q30159678 | Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. |
Q28594765 | Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells |
Q58721533 | Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis |
Q89617856 | Feeling Things Out: Bidirectional Signaling of the Cell-ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation |
Q42829767 | Fibronectin‐mediated cell spreading requires ABBA‐Rac1 signaling |
Q40161753 | Filopodia are induced by aquaporin-9 expression |
Q28279460 | Filopodia: molecular architecture and cellular functions |
Q30524728 | Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues |
Q28829680 | Force-control at cellular membranes |
Q35167532 | Function and regulation of Ena/VASP proteins |
Q24297149 | Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis |
Q28186686 | Genomic organization and expression profile of the human and mouse WAVE gene family |
Q28190085 | Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein |
Q88311426 | Guided by curvature: shaping cells by coupling curved membrane proteins and cytoskeletal forces |
Q88011201 | Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F-box protein subunit |
Q38130179 | How filopodia pull: what we know about the mechanics and dynamics of filopodia. |
Q27350493 | Human Mena associates with Rac1 small GTPase in glioblastoma cell lines |
Q82533830 | I-BAR domain proteins: linking actin and plasma membrane dynamics |
Q47249545 | IRSp53 accumulates at the postsynaptic density under excitatory conditions. |
Q97522672 | IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules |
Q92502754 | IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration |
Q40649467 | IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena |
Q30009886 | IRSp53 mediates podosome formation via VASP in NIH-Src cells |
Q27321489 | IRSp53 senses negative membrane curvature and phase separates along membrane tubules |
Q26798113 | IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders |
Q21284173 | Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2 |
Q33910131 | Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. |
Q37709539 | Insulin receptor signaling in the development of neuronal structure and function. |
Q34674963 | Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo |
Q24322639 | Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1 |
Q37530607 | Kank proteins: structure, functions and diseases |
Q29616036 | Local force and geometry sensing regulate cell functions |
Q28181601 | MALS is a binding partner of IRSp53 at cell-cell contacts |
Q36868323 | MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis |
Q37238333 | Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression |
Q27681941 | Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors |
Q61443023 | Mechanism of IRSp53 inhibition by 14-3-3 |
Q29616648 | Mechanism of filopodia initiation by reorganization of a dendritic network |
Q50796079 | Melanoblasts on the move: Rac1 sets the pace |
Q37902570 | Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily |
Q30438474 | Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2. |
Q47576945 | Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation |
Q37137631 | Miniature protein ligands for EVH1 domains: interplay between affinity, specificity, and cell motility |
Q39734937 | Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism |
Q36955886 | Modulating the dysregulated migration of pulmonary arterial hypertensive smooth muscle cells with motif mimicking cell permeable peptides |
Q55056709 | Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment. |
Q28582299 | NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling |
Q48044144 | Nanoparticle-Cell Interaction: A Cell Mechanics Perspective |
Q36012061 | Neuronal migration and the role of reelin during early development of the cerebral cortex. |
Q55541318 | New concepts in phospholipase D signaling in inflammation and cancer. |
Q34070345 | Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. |
Q24295180 | Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53 |
Q30165426 | Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region |
Q30480399 | Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. |
Q64243535 | Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation by Inhibiting the Akt Pathway |
Q97520122 | Palmitoylated Proteins in Dendritic Spine Remodeling |
Q37751709 | Phosphoinositide-binding interface proteins involved in shaping cell membranes |
Q47136871 | Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3. |
Q38125148 | Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations |
Q41573318 | Possible role of IRTKS in Tks5-driven osteoclast fusion |
Q28583499 | Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons |
Q37571307 | Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development |
Q36557397 | Regulation and functional significance of CDC42 alternative splicing in ovarian cancer |
Q24319871 | Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization |
Q35903441 | Regulation of WASP/WAVE proteins: making a long story short |
Q34495181 | Regulation of Wiskott-Aldrich syndrome protein and related molecules |
Q37542009 | Regulation of actin cytoskeleton dynamics in cells |
Q28505970 | Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex |
Q35605754 | Regulation of cortical actin networks in cell migration. |
Q28580747 | Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases |
Q37677924 | Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides |
Q44043456 | Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion |
Q33818172 | Rho GTPase Cdc42 Is a Direct Interacting Partner of Adenomatous Polyposis Coli Protein and Can Alter Its Cellular Localization |
Q28645748 | Rho and Rac take center stage |
Q59052275 | Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome |
Q24310745 | RhoG signals in parallel with Rac1 and Cdc42 |
Q39588446 | Rif-mDia1 Interaction Is Involved in Filopodium Formation Independent of Cdc42 and Rac Effectors |
Q38201075 | Role of ROBO4 signalling in developmental and pathological angiogenesis |
Q36124814 | SH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth |
Q24312871 | SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling |
Q42120252 | Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature. |
Q42360649 | Self-assembly of filopodia-like structures on supported lipid bilayers |
Q33361898 | Severe learning deficits of IRSp53 mutant mice are caused by altered NMDA receptor dependent signal transduction |
Q37958928 | Shear stress, tip cells and regulators of endothelial migration |
Q33382276 | Silencing of directional migration in roundabout4 knockdown endothelial cells |
Q35071400 | Sticky business: orchestrating cellular signals at adherens junctions |
Q27673160 | Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. |
Q24682067 | Structural basis for the actin-binding function of missing-in-metastasis |
Q24296423 | Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. |
Q24557455 | Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53 |
Q64121943 | Superresolution microscopy reveals distinct localisation of full length IRSp53 and its I-BAR domain protein within filopodia |
Q35916016 | Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes |
Q27006727 | Syndapin--a membrane remodelling and endocytic F-BAR protein |
Q54118981 | Tetraspanin-enriched microdomains regulate digitation junctions. |
Q30010185 | The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases |
Q35662030 | The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity |
Q24336730 | The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics |
Q33981225 | The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation |
Q34317019 | The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis |
Q24304626 | The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation |
Q39066567 | The Role of BAR Domain Proteins in the Regulation of Membrane Dynamics |
Q30008854 | The SH3 domain distinguishes the role of I-BAR proteins IRTKS and MIM in chemotactic response to serum |
Q30157367 | The Toca-1-N-WASP complex links filopodial formation to endocytosis |
Q29616493 | The WASP-WAVE protein network: connecting the membrane to the cytoskeleton |
Q28214043 | The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia |
Q30477234 | The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation |
Q37459389 | The enabled homolog gene polymorphisms are associated with susceptibility and progression of childhood IgA nephropathy |
Q24806492 | The evolutionary history of effectors downstream of Cdc42 and Rac. |
Q28509086 | The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity |
Q28202993 | The lamellipodium: where motility begins |
Q30156083 | The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53. |
Q24528117 | The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein |
Q30156886 | The proposed functions of membrane curvatures mediated by the BAR domain superfamily proteins |
Q35556999 | The role of actin bundling proteins in the assembly of filopodia in epithelial cells |
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Q37270609 | The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics. |
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Q28579676 | Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation |
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Q38981719 | Type III Secreted Virulence Factors Manipulating Signaling to Actin Dynamics. |
Q42832023 | Tyrosine phosphorylation of missing in metastasis protein is implicated in platelet-derived growth factor-mediated cell shape changes |
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