Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

scientific article published on October 30, 2001

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(01)00506-1
P8608Fatcat IDrelease_phi6u3z4jndiropky3vnpipdhi
P953full work available online athttp://www.cell.com/article/S0960982201005061/pdf
https://api.elsevier.com/content/article/PII:S0960982201005061?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0960982201005061?httpAccept=text/xml
P698PubMed publication ID11696321
P5875ResearchGate publication ID11658731

P50authorIngrid JordensQ62131463
P2093author name stringA. Hall
J. Vandekerckhove
K. Gevaert
M. Driessens
S. Krugmann
P2860cites workIdentification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1Q22009908
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome proteinQ22253357
Genetic suppression of mutations in the Drosophila abl proto-oncogene homologQ43634386
Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinaseQ46202539
Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates.Q54621778
Yeast two-hybrid system to detect protein-protein interactions with Rho GTPases.Q54621797
16-BAC/SDS–PAGE: A Two-Dimensional Gel Electrophoresis System Suitable for the Separation of Integral Membrane ProteinsQ55870012
Rho GTPases and their effector proteinsQ56690400
Negative regulation of fibroblast motility by Ena/VASP proteinsQ73990271
Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formationQ77342941
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane rufflingQ24290667
Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actinQ24290738
WIP regulates N-WASP-mediated actin polymerization and filopodium formationQ24291191
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPasesQ24304128
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerizationQ24309118
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPQ24318478
A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP familyQ24532768
The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filamentsQ24653380
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodiaQ24682164
Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenesQ24685793
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switchQ27626911
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
Rho GTPases and the Actin CytoskeletonQ27860579
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formationQ28141490
The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapsesQ28142887
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domainsQ28143912
The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of DrosophilaEnabledQ28257310
Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1Q28273496
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complexQ28293934
Mena is required for neurulation and commissure formationQ28588447
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamicsQ28590972
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphateQ28647599
Rho GTPases and their effector proteinsQ29547740
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblastsQ29614253
Directed actin polymerization is the driving force for epithelial cell-cell adhesionQ29618861
Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of EnabledQ30176335
The clutch hypothesis revisited: ascribing the roles of actin-associated proteins in filopodial protrusion in the nerve growth coneQ30898670
A peptide concentration and purification method for protein characterization in the subpicomole range using matrix assisted laser desorption/ionization‐postsource decay (MALDI‐PSD) sequencingQ32060245
Peptides adsorbed on reverse‐phase chromatographic beads as targets for femtomole sequencing by post‐source decay matrix assisted laser desorption ionization‐reflectron time of flight mass spectrometry (MALDI‐RETOF‐MS)Q32092387
Flipping the switch: the structural basis for signaling through the CRIB motifQ34019126
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectidentical protein bindingQ14762994
BAR/IMD domain containing adaptor protein 2Q21171687
ENAH actin regulatorQ21497088
cytoskeletal proteinsQ66563066
P304page(s)1645-55
P577publication date2001-10-30
P1433published inCurrent BiologyQ1144851
P1476titleCdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
P478volume11

Reverse relations

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