| scholarly article | Q13442814 |
| P2093 | author name string | Rachel J Buchsbaum | |
| Beth A Connolly | |||
| Larry A Feig | |||
| Jared Rice | |||
| P2860 | cites work | The small GTPase RalA targets filamin to induce filopodia | Q22008839 |
| IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling | Q24290667 | ||
| Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin | Q24290738 | ||
| Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex | Q24291871 | ||
| Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53 | Q24295180 | ||
| IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness | Q24300415 | ||
| A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein | Q24306756 | ||
| PAK kinases are directly coupled to the PIX family of nucleotide exchange factors | Q24313368 | ||
| Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade | Q24537458 | ||
| Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation | Q24678943 | ||
| Rho GTPases and the actin cytoskeleton | Q27860579 | ||
| Cell migration: integrating signals from front to back | Q27860670 | ||
| A system for stable expression of short interfering RNAs in mammalian cells | Q27860875 | ||
| Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells | Q27860926 | ||
| EPS8 and E3B1 transduce signals from Ras to Rac | Q28145106 | ||
| The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 | Q28198280 | ||
| WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac | Q28203310 | ||
| Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck | Q28218186 | ||
| Abi1 is essential for the formation and activation of a WAVE2 signalling complex | Q28253079 | ||
| Proteins regulating Ras and its relatives | Q28257295 | ||
| A novel regulator of p21-activated kinases | Q28281325 | ||
| Recruitment of the Arp2/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor | Q28581099 | ||
| Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. | Q28588154 | ||
| The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium | Q28609367 | ||
| WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement | Q28609855 | ||
| Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism | Q34140558 | ||
| Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin | Q34171088 | ||
| A role for Rac in Tiam1-induced membrane ruffling and invasion | Q34310851 | ||
| Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42. | Q34473449 | ||
| Regulation of Tiam1-Rac signalling. | Q35163913 | ||
| Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth | Q39444717 | ||
| IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena | Q40649467 | ||
| N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia | Q40815737 | ||
| Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton | Q41334369 | ||
| Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid | Q42803959 | ||
| Activation of the small GTP-binding proteins rho and rac by growth factor receptors. | Q42831405 | ||
| Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. | Q43918731 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cytoskeleton | Q154626 |
| actin cytoskeleton | Q14860845 | ||
| P304 | page(s) | 4602-4614 | |
| P577 | publication date | 2005-06-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation | |
| P478 | volume | 25 |
| Q37048376 | Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP) |
| Q46890262 | Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons |
| Q38284607 | BAR domain proteins regulate Rho GTPase signaling |
| Q36511644 | Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells |
| Q38992136 | Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease |
| Q36595699 | Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration |
| Q33718591 | Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2 |
| Q57909414 | Eps8 |
| Q41879088 | GEFs: Dual regulation of Rac1 signaling. |
| Q27678967 | High-resolution structure of the Tiam1 PHn-CC-Ex domain |
| Q27350493 | Human Mena associates with Rac1 small GTPase in glioblastoma cell lines |
| Q82533830 | I-BAR domain proteins: linking actin and plasma membrane dynamics |
| Q26798113 | IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders |
| Q34388235 | Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. |
| Q39960579 | Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry |
| Q37980724 | Inhibition and termination of physiological responses by GTPase activating proteins |
| Q41854774 | Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization. |
| Q24322639 | Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1 |
| Q36977342 | Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1. |
| Q27681941 | Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors |
| Q28081571 | Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses |
| Q30438474 | Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2. |
| Q50055475 | Modulation of small GTPase activity by NME proteins |
| Q30480399 | Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. |
| Q59136615 | Optogenetic dissection of Rac1 and Cdc42 gradient shaping |
| Q37143218 | Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors |
| Q34946840 | RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma |
| Q51803381 | Rac is a dominant regulator of cadherin-directed actin assembly that is activated by adhesive ligation independently of Tiam1. |
| Q38839225 | Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms |
| Q28584307 | Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation |
| Q35083736 | Regulation of Neuronal Function by Ras-GRF Exchange Factors |
| Q28505970 | Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex |
| Q26825750 | Regulation of small GTPases by GEFs, GAPs, and GDIs |
| Q47301194 | Rho GTPase signaling complexes in cell migration and invasion |
| Q28257230 | Rho GTPases: functions and association with cancer |
| Q28474499 | Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step |
| Q24312871 | SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling |
| Q33885377 | Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). |
| Q36528170 | Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes |
| Q24336730 | The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics |
| Q24314777 | The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module |
| Q35641633 | The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity |
| Q24305474 | The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion |
| Q28571945 | The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites |
| Q36513706 | The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis |
| Q34384857 | The role of fibroblast Tiam1 in tumor cell invasion and metastasis |
| Q44941768 | Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice |
| Q35770221 | Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells |
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