Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli.

scientific article

Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1007/S00018-006-6148-X
P932PMC publication ID2522319
P698PubMed publication ID16909209
P5875ResearchGate publication ID6878744

P50authorJames R BartlesQ61731612
P2093author name stringL Zheng
E Mugnaini
P A Loomis
G Sekerková
P2860cites workSmall espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilliQ22003897
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complexQ24291871
Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53Q24295180
Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializationsQ24322878
Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cellsQ24595562
The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.Q24603825
Espin gene (ESPN) mutations associated with autosomal dominant hearing loss cause defects in microvillar elongation or organisationQ24654772
Mutations of ESPN cause autosomal recessive deafness and vestibular dysfunctionQ24675125
An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewalQ24676711
Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respirationQ24678604
Structure and function of the vomeronasal system: an updateQ28204583
Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new resultsQ28205409
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathwaysQ28208630
Regulation of calcium signaling by polycystin-2Q28260546
The Origin of Jerker, a New Gene Mutation of the House Mouse, and Linkage Studies Made with ItQ28305464
Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaqueQ28512566
Differential expression of espin isoforms during epithelial morphogenesis, stereociliogenesis and postnatal maturation in the developing inner ear.Q28569411
Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cellsQ28580200
Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPasesQ28580747
Hair cells in the inner ear of the pirouette and shaker 2 mutant miceQ28590250
The cytocaud: a hair cell pathology in the waltzing Guinea pig.Q42525972
"Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotoninQ43824565
Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-beta1, and IP3R-I and -II in Merkel cells in rat sinus hair folliclesQ44475525
Control of the assembly of ATP- and ADP-actin by formins and profilin.Q45345926
Development and properties of stereociliary link types in hair cells of the mouse cochleaQ46388853
Cochlear structure and function in a recessive type of genetically induced inner ear degenerationQ48578507
Variability in genetically induced age-related impairment of auditory brainstem response thresholdsQ48983842
Balanced levels of Espin are critical for stereociliary growth and length maintenance.Q50470145
Postnatal development of the rat organ of Corti. II. Hair cell receptors and their supporting elements.Q50540590
Coincidence detection in single dendritic spines mediated by calcium release.Q51644044
Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear.Q52096957
Genetic and physical maps of jerker (Espn(je)) on mouse chromosome 4.Q52547227
Morphologically specific vestibular hair cell degeneration in the jerker mouse mutantQ68722749
The mammalian taste bud type III cell: a critical analysisQ69144130
Fine structure of taste buds of rabbit foliate papillaeQ72294536
Chemosensory Perception in the GutQ73967355
Localisation of actin, villin, fimbrin, ezrin and ankyrin in rat taste receptor cellsQ78170029
Hair bundle heights in the utricle: differences between macular locations and hair cell typesQ81245942
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammalsQ28591957
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereociliaQ28593953
Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cellsQ28594765
A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transductionQ28594962
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionQ30014849
Genetic analyses of the mouse deafness mutations varitint-waddler (Va) and jerker (Espnje)Q30473461
Actin filaments, stereocilia, and hair cells of the bird cochlea. V. How the staircase pattern of stereociliary lengths is generatedQ30494574
Mechanosensory function of microvilli of the kidney proximal tubuleQ30832338
Identification of cytoskeletal markers for the different microvilli and cell types of the rat vomeronasal sensory epitheliumQ30993962
Identification of Merkel cells by an antibody to villinQ31998527
Parallel actin bundles and their multiple actin-bundling proteins.Q33786549
Strain background effects and genetic modifiers of hearing in miceQ33804884
Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathwayQ33974691
Espin cytoskeletal proteins in the sensory cells of rodent taste budsQ34013341
The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P(2) influences cytoskeletal protein activity at the plasma membraneQ34062572
WH2 domain: a small, versatile adapter for actin monomers.Q34120315
How to make a curved Drosophila bristle using straight actin bundlesQ34245097
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cellsQ34419722
The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?Q34786270
Pheromone detection by mammalian vomeronasal neuronsQ34803956
Phosphoinositide regulation of the actin cytoskeletonQ35019759
Actin filaments, stereocilia, and hair cells: how cells count and measureQ35651717
Genetic insights into the morphogenesis of inner ear hair cells.Q35813847
The role of profilin complexes in cell motility and other cellular processesQ35861651
From placode to polarization: new tunes in inner ear developmentQ35866631
Cellular length control systemsQ35912850
The taste cell-related diffuse chemosensory systemQ36121411
Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.Q36324725
The making of filopodiaQ36335794
Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip linksQ36824187
Molecular profiling reveals synaptic release machinery in Merkel cells.Q37569634
Cochlear dysfunction in the jerker mouseQ38580011
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of MenaQ40649467
Ultrastructure of mouse vallate taste buds: II. Cell types and cell lineageQ41477748
Genetically induced inner ear degeneration. A structural and functional studyQ41786232
Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation.Q42468923
Postnatal development of the hamster cochlea. II. Growth and differentiation of stereocilia bundlesQ42490085
P433issue19-20
P921main subjectcytoskeletonQ154626
actin cytoskeletonQ14860845
P304page(s)2329-2341
P577publication date2006-10-01
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleEspins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli
P478volume63

Reverse relations

cites work (P2860)
Q30607162Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice
Q34201432Actin cross-linkers and the shape of stereocilia
Q30454015Actin in hair cells and hearing loss
Q60926031An actin-binding protein ESPN is an independent prognosticator and regulates cell growth for esophageal squamous cell carcinoma
Q53041387An actin-binding protein espin is a growth regulator for melanoma.
Q30490773Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes
Q24611997Autosomal recessive nonsyndromic deafness genes: a review
Q30356896Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea.
Q33814570Chemosensory organs as models of neuronal synapses
Q33856986Cytoskeletal dynamics and spermatogenesis
Q48304529Developing a sense of touch
Q24646242Dynamic length regulation of sensory stereocilia
Q30484276Espin actin-cytoskeletal proteins are in rat type I spiral ganglion neurons and include splice-isoforms with a functional nuclear localization signal.
Q39889666Evidence that selective changes in the lipid composition of raft-membranes occur during respiratory syncytial virus infection
Q33916876Fascin 2b is a component of stereocilia that lengthens actin-based protrusions
Q30482629Function and expression pattern of nonsyndromic deafness genes
Q39048617Global Analysis of Protein Expression of Inner Ear Hair Cells
Q30374694Hair cell stereociliary bundle regeneration by espin gene transduction after aminoglycoside damage and hair cell induction by Notch inhibition
Q47339721Immunohistochemical characterization of brush cells in the rat larynx.
Q42380606Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions
Q22337239Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction
Q36594218Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Q30490501Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments
Q48518065Overexpression of microRNA-612 Restrains the Growth, Invasion, and Tumorigenesis of Melanoma Cells by Targeting Espin
Q40491961PeakForce Tapping resolves individual microvilli on living cells.
Q30482095Proper cellular reorganization during Drosophila spermatid individualization depends on actin structures composed of two domains, bundles and meshwork, that are differentially regulated and have different functions
Q64101004Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons
Q30476139Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice
Q33756471Structural and viscoelastic properties of actin networks formed by espin or pathologically relevant espin mutants
Q47236946The Actin Cytoskeleton and Actin-Based Motility
Q30389509Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities
Q35674714Whirlin interacts with espin and modulates its actin-regulatory function: an insight into the mechanism of Usher syndrome type II.

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