Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea.

scientific article

Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2017.00122
P932PMC publication ID5405134
P698PubMed publication ID28491023

P50authorHaibo ShiQ50432378
P2093author name stringYan Chen
Muhammad Waqas
Huawei Li
Xiaoli Zhang
Cheng Cheng
Ling Lu
Mingliang Tang
Renjie Chai
Fangyi Chen
Xia Gao
Xiaochen Xu
ShaSha Zhang
Luo Guo
Chengwen Zhu
Junyan Gao
Chuanying Xuan
P2860cites workMammalian cochlear supporting cells can divide and trans-differentiate into hair cellsQ22251095
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of cortiQ24648170
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Identification of stem cells in small intestine and colon by marker gene Lgr5Q28131701
Wnt5a functions in planar cell polarity regulation in miceQ28505898
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of CortiQ28585281
Analysis of Netrin 1 receptors during inner ear developmentQ28585341
Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic spaceQ28591612
Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactionsQ28592897
Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utriclesQ28596069
STRING v9.1: protein-protein interaction networks, with increased coverage and integrationQ29614691
A robust and high-throughput Cre reporting and characterization system for the whole mouse brainQ29616609
Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.Q29871527
Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli.Q30159678
Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea.Q30360502
Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea.Q30367432
SoxC transcription factors are essential for the development of the inner earQ30398509
Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricleQ30401408
PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarityQ30405795
Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivoQ30408063
Cochlear progenitor number is controlled through mesenchymal FGF receptor signalingQ30411351
Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearingQ30411605
Regulated reprogramming in the regeneration of sensory receptor cells.Q30414064
Making sense of Wnt signaling-linking hair cell regeneration to developmentQ30415959
Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cellsQ30428257
Lgr5-positive supporting cells generate new hair cells in the postnatal cochleaQ30441281
Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitorsQ30442841
Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.Q30449308
Role of p63 and the Notch pathway in cochlea development and sensorineural deafnessQ30454583
Regenerated hair cells can originate from supporting cell progeny: evidence from phototoxicity and laser ablation experiments in the lateral line systemQ30456826
Mitochondrial stress engages E2F1 apoptotic signaling to cause deafnessQ30458185
Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochleaQ30460671
Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cellQ30461482
Intrinsic regenerative potential of murine cochlear supporting cells.Q30472028
An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear.Q30474072
Expression of LHX3 and SOX2 during mouse inner ear developmentQ30480292
Expression of Wnt receptors in adult spiral ganglion neurons: frizzled 9 localization at growth cones of regenerating neuritesQ30490948
Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.Q30490970
Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear developmentQ30491894
Anti-apoptotic gene Bcl2 is required for stapes development and hearingQ30524707
Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set.Q30805626
Optimizing Data Intensive GPGPU Computations for DNA Sequence AlignmentQ33531682
Characterization of transcriptomes of cochlear inner and outer hair cellsQ34037606
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signalingQ34197732
Identification of genes concordantly expressed with Atoh1 during inner ear development.Q34822265
HMGA2, the architectural transcription factor high mobility group, is expressed in the developing and mature mouse cochleaQ35097530
Next-generation sequencing identifies mutations of SMPX, which encodes the small muscle protein, X-linked, as a cause of progressive hearing impairmentQ35136932
Nonsense mutations in SMPX, encoding a protein responsive to physical force, result in X-chromosomal hearing lossQ35136943
Genetic analysis of genes related to tight junction function in the Korean population with non-syndromic hearing lossQ35154231
p27(Kip1) is required to maintain proliferative quiescence in the adult cochlea and pituitaryQ35592149
Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochleaQ36160283
Regulation of cell fate in the sensory epithelia of the inner ear.Q36629867
Hair cell regeneration in the avian auditory epithelium.Q36950152
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2Q37130918
Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.Q37169193
Usher proteins in inner ear structure and functionQ37346003
Sensory regeneration in the vertebrate inner ear: differences at the levels of cells and speciesQ37757414
Protection from noise-induced hearing loss with Src inhibitorsQ38338322
Zeb2: A multifunctional regulator of nervous system development.Q38550847
Regeneration of hair cells in the mammalian vestibular systemQ38836733
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochleaQ38928250
Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochleaQ41820010
TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.Q41865763
Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochleaQ42276668
The influence of sphingosine-1-phosphate receptor antagonists on gentamicin-induced hair cell loss of the rat cochleaQ42451981
Growth factors have a protective effect on neomycin-induced hair cell lossQ42462748
Junctionally restricted RhoA activity is necessary for apical constriction during phase 2 inner ear placode invagination.Q42464828
Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha geneQ43811113
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cellsQ44735217
Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling PathwayQ50317124
Temporal expression pattern of Fkbp8 in rodent cochleaQ50432210
Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed miceQ50433292
Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in miceQ50443926
Pluripotent stem cells from the adult mouse inner ear.Q50482567
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.Q50483907
A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene.Q50489252
Regeneration of sensory hair cells after acoustic trauma.Q50563884
Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear.Q50663022
Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition.Q50784299
Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium.Q51926572
Gata3 is required for early morphogenesis and Fgf10 expression during otic development.Q52013723
Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear.Q52021397
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Q52040186
Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis.Q52173415
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.Q53447869
Ongoing production of sensory cells in the vestibular epithelium of the chickQ67737958
Dll3 is expressed in developing hair cells in the mammalian cochleaQ81154349
P921main subjectRNA sequencingQ2542347
P304page(s)122
P577publication date2017-04-26
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleCharacterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea
P478volume10

Reverse relations

cites work (P2860)
Q98288853A Neurophysiological Study of Musical Pitch Identification in Mandarin-Speaking Cochlear Implant Users
Q91612466Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea
Q57486541Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells
Q55362003Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea.
Q89963774Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea
Q47192519Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea
Q54939974Hollow Mesoporous Silica@Zeolitic Imidazolate Framework Capsules and Their Applications for Gentamicin Delivery.
Q55017430Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae.
Q93111529Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea
Q64930524Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2.
Q90430866Transcriptome sequencing of adenomyosis eutopic endometrium: A new insight into its pathophysiology
Q90622989Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5+ cells during mouse inner ear development

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