Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling

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Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.1494-14.2014
P932PMC publication ID4166165
P698PubMed publication ID25232121

P2093author name stringAna Benito-Gonzalez
Angelika Doetzlhofer
P2860cites workComparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genesQ24290157
Regulation of planar cell polarity by Smurf ubiquitin ligasesQ24317525
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal heartsQ24337426
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedQ24682703
The genetics of hair cell development and regenerationQ26864510
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitorsQ27737008
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signalQ28118955
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Roles of Hes genes in neural developmentQ28277468
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressorsQ28505707
Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of CortiQ28506556
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of CortiQ28507372
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterningQ28507384
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayQ28509023
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determinationQ28510708
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube developmentQ28511382
Math1: an essential gene for the generation of inner ear hair cellsQ28513764
Multiple roles of Notch signaling in cochlear developmentQ80390441
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell developmentQ28513897
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of CortiQ28585281
Sox2 is required for sensory organ development in the mammalian inner earQ28585583
The Notch target genes Hey1 and Hey2 are required for embryonic vascular developmentQ28586854
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ developmentQ28587058
Math1 regulates development of the sensory epithelium in the mammalian cochleaQ28588010
Fgf20 is required for sensory epithelial specification in the developing cochleaQ28592558
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activityQ28592781
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Expression of a Delta homologue in prospective neurons in the chickQ29619573
Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochleaQ30481816
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humansQ30484472
Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cellsQ30543598
Generation and characterization of Atoh1-Cre knock-in mouse lineQ33912847
Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner earQ34154079
Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neuronsQ34235191
Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasisQ34637765
A chemical method for fast and sensitive detection of DNA synthesis in vivoQ36497275
The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea.Q36838607
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factorsQ36857288
Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti.Q36928484
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochleaQ36984946
Autoregulation and multiple enhancers control Math1 expression in the developing nervous systemQ38315246
Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells.Q38501945
Math1-driven GFP expression in the developing nervous system of transgenic miceQ40568741
Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.Q40791534
Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat.Q41132164
Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa.Q42136771
Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochleaQ42276668
Postnatal maturation of cochlear sensory hairs in the mouseQ42465229
TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.Q42818173
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brainQ44831571
Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosomeQ46063842
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.Q48523482
Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cellsQ48876492
Rbpj regulates development of prosensory cells in the mammalian inner ear.Q51878537
A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development.Q52014319
Planar and vertical signals control cellular differentiation and patterning in the mammalian cochlea.Q52099027
Mouse gridlockQ58298447
The embryonic and postnatal development of the inner ear of the mouseQ68637919
Development of the inner ear of the mouse: a radioautographic study of terminal mitosesQ72334432
P4510describes a project that usesImageJQ1659584
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
temporal patternQ129176847
P304page(s)12865-12876
P577publication date2014-09-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleHey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling
P478volume34

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cites work (P2860)
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