Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells

scientific article published on 21 September 2015

Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049774275
P356DOI10.1038/ONC.2015.346
P698PubMed publication ID26387541

P50authorThomas BraunQ40760364
P2093author name stringA Schneider
H Hahn
F Nitzki
J Dräger
N Cuvelier
P2860cites workA new secreted protein that binds to Wnt proteins and inhibits their activitiesQ22009380
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitroQ24315704
Small molecule modulation of Smoothened activityQ24540343
Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in miceQ24557452
Wnt signaling in myogenesisQ26991558
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skinQ28190343
The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle developmentQ28206113
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation developmentQ28251735
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in miceQ28312170
An LDL-receptor-related protein mediates Wnt signalling in miceQ28588625
Lineage of origin in rhabdomyosarcoma informs pharmacological responseQ30411722
Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targetingQ30426842
Cis-interactions between Notch and Delta generate mutually exclusive signalling statesQ30494896
Rhabdomyosarcoma--working out the pathwaysQ33739291
Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributedQ33788728
Cardiac and skeletal muscle development in P19 embryonal carcinoma cellsQ33819926
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signalingQ34197732
Looking back to the embryo: defining transcriptional networks in adult myogenesis.Q34210854
Skeletal muscle formation in vertebratesQ34305805
Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cellsQ34308170
Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.Q34420945
MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells.Q34509286
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcomaQ34580128
Segmental patterning of the vertebrate embryonic axisQ34770048
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formationQ34809773
Myogenin and MyoD1 expression in paediatric rhabdomyosarcomasQ35144171
Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.Q35188293
A mouse model of rhabdomyosarcoma originating from the adipocyte lineage.Q36343292
Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?Q37325228
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.Q37598845
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Q37598848
Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcomaQ37702007
Renaissance of brown adipose tissueQ37849516
Effects of RAS on the genesis of embryonal rhabdomyosarcoma.Q38301662
Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockoutsQ38510595
Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.Q39094389
Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitroQ39617252
Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesisQ41917751
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeQ42455110
Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growthQ42823186
Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochordQ44897702
Childhood rhabdomyosarcoma. Anatomo-clinical and therapeutic study on 25 cases. Surgical implications.Q45386764
Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesisQ50336920
Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis.Q50892898
The Hedgehog receptor Patched controls lymphoid lineage commitment.Q50899169
Distinct regulatory elements direct delta1 expression in the nervous system and paraxial mesoderm of transgenic mice.Q52166660
Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.Q52182362
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.Q52202953
Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcomaQ57243407
Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2Q63951631
Separable regulatory elements governing myogenin transcription in mouse embryogenesisQ70464640
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decisionQ74211426
Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neuronsQ79744649
Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivativesQ81729304
Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant miceQ84166311
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectrhabdomyosarcomaQ1898141
P304page(s)2923-2931
P577publication date2015-09-21
P1433published inOncogeneQ1568657
P1476titleHedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells
P478volume35

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cites work (P2860)
Q47782462A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma
Q60046466Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas
Q58800972Hedgehog Signaling Pathway and Autophagy in Cancer

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