Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro

scientific article published on 21 December 2010

Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-10-0166
P698PubMed publication ID21177409

P2093author name stringJaume Reventós
Josep Roma
Soledad Gallego
Josep Sánchez de Toledo
Anna Masià
P2860cites workCritical role of notch signaling in osteosarcoma invasion and metastasisQ39352960
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectneoplastic invasivenessQ112498967
rhabdomyosarcomaQ1898141
P304page(s)505-513
P577publication date2010-12-21
P1433published inClinical Cancer ResearchQ332253
P1476titleNotch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro
P478volume17

Reverse relations

cites work (P2860)
Q47782462A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma
Q93188577Comparison of cachectic and non-cachectic sarcoma patients reveals an important role of Notch signaling in metastasis and myogenesis
Q36888312Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling
Q30426842Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting
Q39144774Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma.
Q39277802HES6 enhances the motility of alveolar rhabdomyosarcoma cells.
Q38834036Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells
Q36546768Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway
Q33567866Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.
Q91876352Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation
Q37378867Inflammatory stress and sarcomagenesis: a vicious interplay
Q30427044Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.
Q35622015Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis
Q34475754Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program
Q34267924New therapeutic targets in soft tissue sarcoma
Q34480012Notch signaling in pediatric soft tissue sarcomas
Q28072977Notch signalling pathway as an oncogenic factor involved in cancer development
Q42153919Notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network
Q39279019Notch-mediated induction of N-cadherin and α9-integrin confers higher invasive phenotype on rhabdomyosarcoma cells
Q26858778Notch: a key regulator of tumor angiogenesis and metastasis
Q37001697Oncogenic role of the Notch pathway in primary liver cancer.
Q38105879Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.
Q34335672RBPJ is a novel target for rhabdomyosarcoma therapy
Q35828593SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation
Q58707604Soft Tissue Sarcoma Cancer Stem Cells: An Overview
Q26770333Spanning the genomics era: the vital role of a single institution biorepository for childhood cancer research over a decade
Q21285014Targeted therapies in sarcomas: challenging the challenge
Q38671086The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma
Q38211082The role of inflammation in sarcoma
Q37931268Therapeutic pipeline for soft-tissue sarcoma

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