Notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network

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Notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/695603
P8608Fatcat IDrelease_3iojoatk45chtdpjucfymdmkme
P932PMC publication ID3329671
P698PubMed publication ID22550422
P5875ResearchGate publication ID224879586

P50authorJosep RomaQ42153969
Soledad GallegoQ42153975
P2093author name stringJosep Sánchez de Toledo
Anna Almazán-Moga
P2860cites workInhibitory Gli3 activity negatively regulates Wnt/beta-catenin signalingQ24298606
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell CarcinomaQ24303922
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndromeQ24336457
The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.Q51037633
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells.Q52841003
Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcomaQ57243407
Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma studyQ73553819
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissueQ79358419
Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumorsQ82499265
Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: relevance of crosstalk mechanismsQ39772226
Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interactionQ39919033
Crosstalk of hedgehog and Wnt pathways in gastric cancerQ40017476
WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer.Q40028745
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts.Q40966848
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulationQ41935565
Molecular characterization of Patched-associated rhabdomyosarcoma.Q42444281
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeQ42455110
The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).Q42655963
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathwayQ42730230
Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomasQ43865493
Beta-catenin mutation does not seem to have an effect on the tumorigenesis of pediatric rhabdomyosarcomasQ45164999
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
Patching the gaps in Hedgehog signallingQ45345885
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant miceQ46156118
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathwayQ48057050
Interaction between Wingless and Notch signaling pathways mediated by dishevelledQ50319776
Notch signaling: cell fate control and signal integration in developmentQ27861061
beta-catenin signaling and cancerQ28139147
Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathwaysQ28177635
Mutations affecting segment number and polarity in DrosophilaQ28273492
Human homolog of patched, a candidate gene for the basal cell nevus syndromeQ28281033
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumorsQ33252671
Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.Q34000246
Inhibition of the hedgehog pathway in advanced basal-cell carcinomaQ34019208
Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases.Q34156385
Impaired Wnt signaling in embryonal rhabdomyosarcoma cells from p53/c-fos double mutant miceQ34162514
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcomaQ34334974
Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcomaQ34341396
The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.Q34688196
Clinical implications of hedgehog signaling pathway inhibitorsQ35108046
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursorsQ35163647
Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.Q35188293
The Wnt signaling pathway in solid childhood tumorsQ35212566
Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agentsQ35551147
Wnt signaling through canonical and non-canonical pathways: recent progressQ36194509
The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesisQ36222543
Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcomaQ36858083
WNT signaling pathway and stem cell signaling networkQ36883377
A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesisQ36949613
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancerQ37158989
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.Q37482716
Modulators of the hedgehog signaling pathwayQ37779920
Hedgehog signaling pathway as a therapeutic target in various types of cancerQ37890489
Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.Q39094389
Critical role of notch signaling in osteosarcoma invasion and metastasisQ39352960
Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograftQ39598196
Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitroQ39617252
Increased expression of the hedgehog signaling pathway in pediatric solid malignanciesQ39740299
Notch3 gene amplification in ovarian cancerQ39759149
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectrhabdomyosarcomaQ1898141
P304page(s)695603
P577publication date2012-03-11
P1433published inSarcomaQ26841949
P1476titleNotch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network
P478volume2012

Reverse relations

cites work (P2860)
Q37687668Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells.
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Q34659806Emerging therapies for adult soft tissue sarcoma.
Q53026426HES1 as an independent prognostic marker in esophageal squamous cell carcinoma.
Q42323550Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.
Q47980023Logical modelling of Drosophila signalling pathways
Q34790185Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia
Q38816754Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines
Q28512043Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma
Q95388147Rhabdomyosarcoma
Q26823066Roles for Hedgehog signaling in adult organ homeostasis and repair
Q37498644Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling
Q58707604Soft Tissue Sarcoma Cancer Stem Cells: An Overview
Q35904534Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

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