Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.

scientific article

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PBC.23174
P932PMC publication ID3164386
P698PubMed publication ID21618411
P5875ResearchGate publication ID51170752

P50authorDavid K. CrossmanQ42773739
Joseph G PresseyQ56073231
Frederic G. BarrQ112547144
James R. AndersonQ112547434
P2093author name stringJames C Lynch
P2860cites workNonparametric Estimation from Incomplete ObservationsQ25938997
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.Q27851485
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumoursQ28206040
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformationQ28207216
Hedgehog signaling in animal development: paradigms and principlesQ28208463
Prediction of central nervous system embryonal tumour outcome based on gene expressionQ29618619
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic diseaseQ33951643
Inhibition of the hedgehog pathway in advanced basal-cell carcinomaQ34019208
Evaluation of survival data and two new rank order statistics arising in its considerationQ34054360
Mutations in SUFU predispose to medulloblastomaQ34133729
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonistsQ35785923
Paracrine Hedgehog signaling in cancerQ37564811
GDC-0449--targeting the hedgehog signaling pathwayQ37674252
Nevoid basal-cell carcinoma syndromeQ39759038
The EWS/FLI1 oncogenic transcription factor deregulates GLI1.Q40034798
The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1AQ40677917
The Gorlin syndrome gene: a tumor suppressor active in basal cell carcinogenesis and embryonic development.Q40983924
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449Q42031842
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeQ42455110
Case report: nasopharyngeal rhabdomyosarcoma and Gorlin's naevoid basal cell carcinoma syndromeQ42465028
A frequent activated smoothened mutation in sporadic basal cell carcinomasQ42467910
Hedgehog controls neural stem cells through p53-independent regulation of NanogQ42474956
Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma developmentQ42486654
Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcomaQ57243407
Undifferentiated sarcomas of children: pathology and clinical behavior--an Intergroup Rhabdomyosarcoma studyQ73488000
Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma studyQ73553819
Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypesQ77538121
P433issue6
P921main subjectembryonal rhabdomyosarcomaQ5370233
P304page(s)930-938
P577publication date2011-05-25
P1433published inPediatric Blood & CancerQ15754342
P1476titleHedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group
P478volume57

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cites work (P2860)
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Q36030949CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV
Q41847776Calcitriol inhibits hedgehog signaling and induces vitamin d receptor signaling and differentiation in the patched mouse model of embryonal rhabdomyosarcoma
Q50027091Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group
Q48138311Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.
Q92542126Current and Future Treatment Strategies for Rhabdomyosarcoma
Q57492122Different Response of Mutant and Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors
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Q38820614FOXM1 expression in rhabdomyosarcoma: a novel prognostic factor and therapeutic target
Q35067950GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
Q44315676Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction
Q40803127Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell Lines
Q50116993Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors.
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Q38902471Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma
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