Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma

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Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2010.368
P698PubMed publication ID20818440

P50authorSimone FuldaQ21264686
Edoardo MissiagliaQ56426845
Kathryn Pritchard-JonesQ56560148
Janet ShipleyQ60537989
P2093author name stringH Hahn
A Rosenberger
A Zibat
P2860cites workRepression of smoothened by patched-dependent (pro-)vitamin D3 secretionQ21146049
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology groupQ28201860
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumoursQ28206040
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesisQ29614405
Rhabdomyosarcoma--working out the pathwaysQ33739291
Inhibition of the hedgehog pathway in advanced basal-cell carcinomaQ34019208
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specificationQ34108593
Hedgehog signalling in cancer formation and maintenanceQ34291589
Communicating with HedgehogsQ34407911
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Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group studyQ36766818
Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology GroupQ37071890
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.Q37482716
Rhabdomyosarcoma in childrenQ37485855
Effects of RAS on the genesis of embryonal rhabdomyosarcoma.Q38301662
Increased expression of the hedgehog signaling pathway in pediatric solid malignanciesQ39740299
Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor developmentQ39880703
The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activationQ40233567
Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomasQ40254065
Hedgehog signalling in prostate regeneration, neoplasia and metastasisQ40516539
Expression profiling and identification of novel genes involved in myogenic differentiation.Q40605368
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancerQ40664922
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449Q42031842
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeQ42455110
Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma developmentQ42486654
Medulloblastoma growth inhibition by hedgehog pathway blockadeQ44119270
Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adultsQ46118402
Pleiotropic effects of sonic hedgehog on muscle satellite cells.Q46589313
Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcomaQ48714160
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.Q52062326
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.Q52087418
Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma.Q54434638
Targeting the Hedgehog pathway in cancerQ79397666
Subtype and prognostic classification of rhabdomyosarcoma by immunohistochemistryQ82161721
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectalveolar rhabdomyosarcomaQ4737958
P304page(s)6323-6330
P577publication date2010-09-06
P1433published inOncogeneQ1568657
P1476titleActivation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma
P478volume29

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