Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice

scientific article published on 23 May 2011

Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049138688
P356DOI10.1038/ONC.2011.157
P698PubMed publication ID21602886

P50authorThomas BraunQ40760364
P2093author name stringA Schneider
W Schulz-Schaeffer
H Hahn
A Frommhold
A Zibat
F Nitzki
P2860cites workActivation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcomaQ57243407
Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells.Q59120502
Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2Q63951631
Fishing for the origins of cancerQ80421832
Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesisQ80958958
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalitiesQ24315810
Sonic hedgehog in temporal control of somite formationQ24633176
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinaseQ29615040
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by HedgehogQ29615369
Hedgehog: functions and mechanismsQ29619190
Rhabdomyosarcoma--working out the pathwaysQ33739291
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.Q33772264
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specificationQ34108593
The hedgehog signaling pathway in cancerQ34576345
Cellular heterogeneity during vertebrate skeletal muscle developmentQ36870830
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cellsQ36882529
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.Q37598845
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Q37598848
Effects of RAS on the genesis of embryonal rhabdomyosarcoma.Q38301662
Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockoutsQ38510595
Nevoid basal-cell carcinoma syndromeQ39759038
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeQ42455110
Detecting tissue-specific alternative splicing and disease-associated aberrant splicing of the PTCH gene with exon junction microarraysQ42484854
Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma developmentQ42486654
Unbalanced overexpression of the mutant allele in murine Patched mutantsQ42521492
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal deathQ43409060
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant miceQ46156118
Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissuesQ48189802
Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcomaQ48714160
The Hedgehog receptor Patched controls lymphoid lineage commitment.Q50899169
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.Q52062326
Apoptosis of epaxial myotome in Danforth's short-tail (Sd) mice in somites that form following notochord degeneration.Q52182447
Proliferative lesions of oviduct and uterus in CD-1 mice exposed prenatally to tamoxifen.Q53439470
P433issue43
P921main subjectembryonal rhabdomyosarcomaQ5370233
heterozygosityQ124059385
P304page(s)4428-4436
P577publication date2011-05-23
P1433published inOncogeneQ1568657
P1476titleUncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice
P478volume30

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cites work (P2860)
Q26852801A comparative review of canine and human rhabdomyosarcoma with emphasis on classification and pathogenesis
Q41847776Calcitriol inhibits hedgehog signaling and induces vitamin d receptor signaling and differentiation in the patched mouse model of embryonal rhabdomyosarcoma
Q60046466Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas
Q43080027Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity
Q38834036Hedgehog/Patched-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells
Q33688560MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis
Q26783611Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions
Q35832313Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy
Q36253616Patched knockout mouse models of Basal cell carcinoma
Q38105879Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.
Q37232227Targeting hedgehog signaling in cancer: research and clinical developments
Q33586736Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma
Q36240079The Hedgehog pathway: role in cell differentiation, polarity and proliferation
Q37649642Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice.
Q90266281Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer

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