| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Manfred Gessler | Q51953060 |
| P2093 | author name string | Andreas Fischer | |
| P2860 | cites work | Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system | Q22253240 |
| The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation | Q22254254 | ||
| Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes | Q24290157 | ||
| Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm | Q24290956 | ||
| HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling | Q24291533 | ||
| Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression | Q24292887 | ||
| Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function | Q34458950 | ||
| Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split | Q34466443 | ||
| Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo | Q34820104 | ||
| The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis | Q35032269 | ||
| Hey bHLH factors in cardiovascular development. | Q35176828 | ||
| Hey genes in cardiovascular development | Q35201172 | ||
| Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms | Q35669224 | ||
| Notch function in the vasculature: insights from zebrafish, mouse and man. | Q35677633 | ||
| Coupling segmentation to axis formation | Q35946425 | ||
| Endothelial cell diversity revealed by global expression profiling | Q35977148 | ||
| Turning it up a Notch: cross-talk between TGF beta and Notch signaling | Q36017991 | ||
| Sirtuins in aging and age-related disease. | Q36549075 | ||
| Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression | Q36556397 | ||
| A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system | Q36718225 | ||
| Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression | Q36772826 | ||
| Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains | Q36816516 | ||
| Identification of p53 regulators by genome-wide functional analysis | Q37073614 | ||
| Transcriptional regulation of the human acid alpha-glucosidase gene. Identification of a repressor element and its transcription factors Hes-1 and YY1. | Q38307429 | ||
| Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins | Q38323651 | ||
| The notch pathway intermediate HES-1 silences CD4 gene expression | Q38331303 | ||
| Mammalian hairy and Enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis | Q71017041 | ||
| Notch signaling induces rapid degradation of achaete-scute homolog 1. | Q24293622 | ||
| Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2 | Q24294772 | ||
| CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6 | Q24295291 | ||
| Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations | Q24298328 | ||
| Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism | Q24306881 | ||
| Mutations in NOTCH1 cause aortic valve disease | Q24307999 | ||
| Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif | Q24308186 | ||
| Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice | Q24310111 | ||
| Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover | Q24315524 | ||
| Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements | Q24318691 | ||
| Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts | Q24337426 | ||
| HERP, a new primary target of Notch regulated by ligand binding | Q24550855 | ||
| Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms | Q24554353 | ||
| Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2. | Q24562854 | ||
| Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation | Q24603636 | ||
| The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function | Q24657772 | ||
| Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling | Q24676708 | ||
| Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation | Q24678677 | ||
| Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms | Q24682396 | ||
| HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | Q24685454 | ||
| Hairy transcriptional repression targets and cofactor recruitment in Drosophila | Q24802738 | ||
| Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split | Q28139474 | ||
| Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis | Q28140345 | ||
| HES and HERP families: multiple effectors of the Notch signaling pathway | Q28205103 | ||
| Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2 | Q28208853 | ||
| Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop | Q28210742 | ||
| Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation | Q28213629 | ||
| Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression | Q28216123 | ||
| Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins | Q28243184 | ||
| Notch signaling: control of cell communication and cell fate | Q28245948 | ||
| Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling | Q28262816 | ||
| HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box | Q28271374 | ||
| Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome | Q28283975 | ||
| Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells | Q28288593 | ||
| Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation | Q28288889 | ||
| Signalling downstream of activated mammalian Notch | Q28289832 | ||
| Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development | Q28292810 | ||
| GATA1 in normal and malignant hematopoiesis | Q28303169 | ||
| Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system | Q28304868 | ||
| Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition | Q28505095 | ||
| Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. | Q28505355 | ||
| Instability of Hes7 protein is crucial for the somite segmentation clock | Q28505422 | ||
| Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina | Q28505981 | ||
| Multiple requirements for Hes 1 during early eye formation | Q28506484 | ||
| Hes6 regulates myogenic differentiation | Q28507705 | ||
| Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects | Q28507755 | ||
| Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction | Q28507892 | ||
| Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1 | Q28508013 | ||
| Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors | Q28510928 | ||
| Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium | Q28511675 | ||
| HERP1 is a cell type-specific primary target of Notch | Q28512071 | ||
| Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain | Q28512123 | ||
| Control of endodermal endocrine development by Hes-1 | Q28513574 | ||
| Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split | Q28566005 | ||
| The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1 | Q28567639 | ||
| A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players | Q28571754 | ||
| Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1 | Q28571984 | ||
| Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system | Q28576340 | ||
| Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split | Q28577019 | ||
| The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain | Q28577356 | ||
| Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway | Q28579105 | ||
| Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain | Q28581122 | ||
| Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse | Q28586430 | ||
| The Notch target genes Hey1 and Hey2 are required for embryonic vascular development | Q28586854 | ||
| Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor | Q28587239 | ||
| Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear | Q28592816 | ||
| Dynamic expression and essential functions of Hes7 in somite segmentation | Q28593057 | ||
| Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4 | Q28593631 | ||
| Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes | Q28593674 | ||
| Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm | Q28594325 | ||
| Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system | Q28594530 | ||
| A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development | Q28609065 | ||
| The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription | Q28609066 | ||
| Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors | Q28610134 | ||
| Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos | Q28646232 | ||
| Notch signalling: a simple pathway becomes complex | Q29555851 | ||
| Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia | Q29614269 | ||
| Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression | Q30445281 | ||
| Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells | Q30476642 | ||
| Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein | Q33613008 | ||
| Hey1, a mediator of notch signaling, is an androgen receptor corepressor | Q33823680 | ||
| Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression | Q33888622 | ||
| Regulation of the pancreatic pro-endocrine gene neurogenin3. | Q33945269 | ||
| HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression | Q33965118 | ||
| HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1. | Q34356301 | ||
| Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. | Q34415806 | ||
| Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression | Q34440560 | ||
| Notch signaling represses myocardin-induced smooth muscle cell differentiation | Q38332395 | ||
| Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity | Q38340399 | ||
| Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells | Q38359652 | ||
| Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells | Q38446384 | ||
| Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. | Q39320608 | ||
| Negative regulation of CD4 gene expression by a HES-1-c-Myb complex | Q39458972 | ||
| Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate | Q40219486 | ||
| HES1 cooperates with pRb to activate RUNX2-dependent transcription | Q40271544 | ||
| KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoter | Q40283008 | ||
| Hypoxia requires notch signaling to maintain the undifferentiated cell state | Q40356897 | ||
| The bHLH gene Hes1 is essential for expansion of early T cell precursors | Q40444843 | ||
| Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1. | Q40488277 | ||
| Hes-1, a known transcriptional repressor, acts as a transcriptional activator for the human acid alpha-glucosidase gene in human fibroblast cells | Q40749571 | ||
| Translational repression determines a neuronal potential in Drosophila asymmetric cell division | Q40808595 | ||
| Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex | Q42156247 | ||
| The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin | Q42484713 | ||
| Functional analysis of Hes-1 in preadipocytes | Q42808153 | ||
| Transcriptional repression by the bHLH-Orange factor XHRT1 does not involve the C-terminal YRPW motif | Q42825071 | ||
| The function of hairy-related bHLH repressor proteins in cell fate decisions | Q43169565 | ||
| The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain | Q44831571 | ||
| Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro | Q45042433 | ||
| Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene | Q45304776 | ||
| p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors | Q46193497 | ||
| Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete | Q46252846 | ||
| The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation | Q46630870 | ||
| A bHLH transcriptional network regulating the specification of retinal ganglion cells | Q46633565 | ||
| HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes | Q46905363 | ||
| Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination | Q47070171 | ||
| bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes | Q47071115 | ||
| Two modes of recruitment of E(spl) repressors onto target genes. | Q47071238 | ||
| Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas | Q47073395 | ||
| Subcellular localization and regulation of hypoxia-inducible factor-2alpha in vascular endothelial cells | Q47873293 | ||
| Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis | Q48041941 | ||
| Regulation of hippocampal neuronal differentiation by the basic helix-loop-helix transcription factors HES-1 and MASH-1. | Q48204703 | ||
| Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system | Q48430428 | ||
| Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems | Q48633252 | ||
| Role of the Sc C terminus in transcriptional activation and E(spl) repressor recruitment. | Q50988417 | ||
| Expression of hes6, a new member of the Hairy/Enhancer-of-split family, in mouse development. | Q51079244 | ||
| The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells. | Q51083601 | ||
| Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. | Q52050913 | ||
| Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation. | Q52165453 | ||
| Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. | Q52541748 | ||
| Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. | Q52570711 | ||
| Characterization of hey bHLH genes in teleost fish | Q58298418 | ||
| Mouse gridlock | Q58298447 | ||
| Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers | Q58298473 | ||
| Molecular Recognition of Transcriptional Repressor Motifs by the WD Domain of the Groucho/TLE Corepressor | Q60602049 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial | Q6936496 |
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | basic helix-loop-helix transcription factor | Q377955 |
| transcription factor | Q407384 | ||
| DNA-binding protein | Q2252764 | ||
| P304 | page(s) | 4583-4596 | |
| P577 | publication date | 2007-06-22 | |
| P1433 | published in | Nucleic Acids Research | Q135122 |
| P1476 | title | Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors | |
| P478 | volume | 35 |
| Q36559556 | A bovine herpesvirus 1 protein expressed in latently infected neurons (ORF2) promotes neurite sprouting in the presence of activated Notch1 or Notch3. |
| Q33912279 | A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2 |
| Q26864897 | A role for partial endothelial-mesenchymal transitions in angiogenesis? |
| Q60428656 | A thyroid hormone receptor/KLF9 axis in human hepatocytes and pluripotent stem cells |
| Q38888721 | AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling. |
| Q45923739 | Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims. |
| Q27324100 | Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors |
| Q30384852 | Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity. |
| Q46944236 | Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy |
| Q51847202 | An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination. |
| Q33997193 | An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells |
| Q34566387 | An intact brachyury function is necessary to prevent spurious axial development in Xenopus laevis. |
| Q52316983 | Attenuated Notch signaling in schizophrenia and bipolar disorder. |
| Q41489621 | Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. |
| Q47798993 | Basic helix-loop-helix transcription factors in evolution: Roles in development of mesoderm and neural tissues |
| Q90145423 | Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury |
| Q37961977 | Cancer stem cell epigenetics and chemoresistance. |
| Q24338286 | Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling |
| Q39404097 | Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis. |
| Q41950896 | Combining Notch inhibition with current therapies for breast cancer treatment |
| Q34342220 | Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events |
| Q34152677 | Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival |
| Q36778072 | Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence |
| Q53506137 | Cooperative genetic defects in TLX3 rearranged pediatric T-ALL. |
| Q38840586 | Correlation of Notch1/Hes1 Genes Expression Levels in Egyptian Paediatric Patients with Newly Diagnosed and Persistent Primary Immune(Idiopathic) Thrombocytopenic Purpura |
| Q30663602 | Cross-tissue and cross-species analysis of gene expression in skeletal muscle and electric organ of African weakly-electric fish (Teleostei; Mormyridae). |
| Q35578568 | Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice |
| Q37311681 | Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord |
| Q34979900 | Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression |
| Q36417076 | Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation |
| Q39177651 | Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-β signalling pathway |
| Q38341139 | Different degrees of structural order in distinct regions of the transcriptional repressor HES-1 |
| Q24338948 | Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats |
| Q37086159 | Differential gene expression in a coculture model of angiogenesis reveals modulation of select pathways and a role for Notch signaling |
| Q50353951 | Differential regulation of Hes/Hey genes during inner ear development |
| Q38160495 | Disruption of prostate epithelial differentiation pathways and prostate cancer development |
| Q36897612 | Drosophila CK2 phosphorylates Hairy and regulates its activity in vivo |
| Q42125235 | Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis |
| Q49344558 | Dynamic Ligand Discrimination in the Notch Signaling Pathway. |
| Q42050873 | Dynamic reprogramming of chromatin: paradigmatic palimpsests and HES factors |
| Q34981620 | Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle |
| Q37120245 | Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival |
| Q44706927 | Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice |
| Q45967645 | Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis. |
| Q39285307 | Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression |
| Q35792075 | Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State |
| Q38652846 | Expression of HES and HEY genes in infantile hemangiomas |
| Q45120648 | Expression of hairy/enhancer of split genes in neural progenitors and neurogenesis domains of the adult zebrafish brain |
| Q34145324 | Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock |
| Q90459214 | Extramacrochaetae promotes branch and bouton number via the sequestration of daughterless in the cytoplasm of neurons |
| Q48184435 | Functional analysis of Hairy genes in Xenopus neural crest initial specification and cell migration. |
| Q37138197 | Functional role of Notch signaling in the developing and postnatal heart |
| Q36197098 | GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis |
| Q39416430 | GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development. |
| Q38540891 | GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation. |
| Q38697005 | Genetics of cognitive control: Implications for Nimh's research domain criteria initiative |
| Q38342443 | Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines |
| Q27333095 | Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response |
| Q33930490 | Genome-wide significant localization for working and spatial memory: Identifying genes for psychosis using models of cognition |
| Q39033874 | Genomic Control of Retinal Cell Number: Challenges, Protocol, and Results |
| Q30391509 | Genomic control of neuronal demographics in the retina |
| Q34509386 | HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass |
| Q34788468 | HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors |
| Q39277802 | HES6 enhances the motility of alveolar rhabdomyosarcoma cells. |
| Q33769686 | HES6-1 and HES6-2 function through different mechanisms during neuronal differentiation |
| Q92512101 | HEY2 acting as a co-repressor with smad3 and smad4 interferes with the response of TGF-beta in hepatocellular carcinoma |
| Q30528663 | HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway |
| Q37048325 | Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice |
| Q42270552 | Hairy/enhancer of Split Homologue-1 Suppresses Vascular Endothelial Growth Factor-induced Angiogenesis via Downregulation of Osteopontin Expression |
| Q28388706 | Hes-1 SUMOylation by protein inhibitor of activated STAT1 enhances the suppressing effect of Hes-1 on GADD45α expression to increase cell survival |
| Q36213706 | Hes1: a key role in stemness, metastasis and multidrug resistance |
| Q38846188 | Hes1: the maestro in neurogenesis. |
| Q51870175 | Hes6 is required for actin cytoskeletal organization in differentiating C2C12 myoblasts. |
| Q30481816 | Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea |
| Q35693118 | Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. |
| Q35661779 | Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus |
| Q34197732 | Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling |
| Q28507372 | Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti |
| Q33831060 | Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells |
| Q42911055 | History of a prolific family: the Hes/Hey-related genes of the annelid Platynereis |
| Q28593714 | Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis |
| Q37334128 | Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment |
| Q27324283 | In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse |
| Q52715373 | Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis. |
| Q37048321 | Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE) |
| Q28590418 | Increased expression of angiogenic genes in the brains of mouse meg3-null embryos |
| Q91714257 | Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury |
| Q33911184 | Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature |
| Q36977850 | Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways |
| Q27335469 | Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance |
| Q37298113 | Isolation, characterization, and molecular regulation of muscle stem cells. |
| Q26864457 | It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain |
| Q39860632 | Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway |
| Q36697420 | LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans |
| Q39136332 | Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures |
| Q91657393 | Loss of the serine protease HTRA1 impairs smooth muscle cells maturation |
| Q38720677 | MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway |
| Q33859334 | Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells |
| Q37122548 | Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination |
| Q33658871 | Mechanisms of iron metabolism in Caenorhabditis elegans |
| Q37102334 | MicroRNAs in cerebral ischemia-induced neurogenesis |
| Q33827953 | Modelling the Delta1/Notch1 pathway: in search of the mediator(s) of neural stem cell differentiation |
| Q61799187 | N-terminal phosphorylation of xHes1 controls inhibition of primary neurogenesis in Xenopus |
| Q37396888 | NOTCH signaling in Sertoli cells regulates gonocyte fate |
| Q38827480 | Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways |
| Q34541637 | No evidence for a functional role of bi-directional Notch signaling during angiogenesis |
| Q36960089 | Notch Signaling and the Skeleton |
| Q42203506 | Notch Signaling during Oogenesis in Drosophila melanogaster |
| Q89132880 | Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis |
| Q37785199 | Notch Targets and Their Regulation |
| Q47073573 | Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. |
| Q57030143 | Notch and interacting signalling pathways in cardiac development, disease, and regeneration |
| Q33627230 | Notch and the skeleton |
| Q43055867 | Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme |
| Q34707176 | Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia |
| Q36267714 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9. |
| Q64079376 | Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge |
| Q33747041 | Notch signaling in glioblastoma: a developmental drug target? |
| Q47840900 | Notch signaling in the epididymal epithelium regulates sperm motility and is transferred at a distance within epididymosomes |
| Q38367417 | Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology |
| Q35041145 | Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation |
| Q41326624 | Notch signaling regulates growth and differentiation in the mammalian lens |
| Q37373005 | Notch signalling in cancer stem cells. |
| Q34523375 | Notch signalling in cardiovasculogenesis: insight into their role in early cardiovascular development |
| Q38923306 | Notch signalling in context |
| Q93003838 | Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments |
| Q50790389 | Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma. |
| Q39484183 | Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation |
| Q31061914 | Notch2 and Notch3 function together to regulate vascular smooth muscle development. |
| Q37515480 | Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors |
| Q38324552 | Notching on Cancer's Door: Notch Signaling in Brain Tumors |
| Q51799517 | Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. |
| Q38068543 | Patterning and cell fate in the inner ear: a case for Notch in the chicken embryo |
| Q92185693 | Patterning via local cell-cell interactions in developing systems |
| Q37091668 | Pax7 is regulated by cMyb during early neural crest development through a novel enhancer |
| Q35189507 | Precise cis-regulatory control of spatial and temporal expression of the alx-1 gene in the skeletogenic lineage of s. purpuratus |
| Q39889923 | Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation. |
| Q35956435 | Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells |
| Q41864659 | Regulation of germ line stem cell homeostasis |
| Q36072089 | Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat |
| Q26866160 | Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control. |
| Q35584425 | Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells |
| Q33794069 | Sex determination in Drosophila: The view from the top. |
| Q37929090 | Signaling epigenetics: novel insights on cell signaling and epigenetic regulation |
| Q28581831 | Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway |
| Q38215306 | Splenic hamartomas in Alagille syndrome: case report and literature review |
| Q38412355 | Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease |
| Q47197698 | Sumoylation of Notch1 represses its target gene expression during cell stress |
| Q99634239 | Sustained activation of notch signaling maintains tumor-initiating cells in a murine model of liposarcoma |
| Q38739472 | TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis |
| Q28505707 | Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors |
| Q89107305 | Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development |
| Q35200235 | Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3 |
| Q50679508 | Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish. |
| Q34339730 | Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo |
| Q30499442 | The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. |
| Q33903422 | The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish |
| Q35741905 | The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. |
| Q38723037 | The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells |
| Q42255131 | The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation. |
| Q36971953 | The Notch signaling pathway as a mediator of tumor survival |
| Q64964461 | The Notch system during pubertal development of the bovine mammary gland. |
| Q34988184 | The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells |
| Q34441979 | The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch |
| Q58695682 | The bHLH transcription factor DEC1 promotes thyroid cancer aggressiveness by the interplay with NOTCH1 |
| Q33770292 | The bHLH transcription factor, hairy, refines the terminal cell fate in the Drosophila embryonic trachea |
| Q27688110 | The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA |
| Q45410799 | The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression. |
| Q35854221 | The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. |
| Q37028771 | The multifaceted role of Notch in cardiac development and disease |
| Q34146497 | The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1. |
| Q37608930 | The role of notch signaling in the development of a normal B-cell repertoire |
| Q38155419 | The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms |
| Q41759830 | The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis |
| Q39036247 | Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line |
| Q36192998 | Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis. |
| Q28481517 | Topology and dynamics of the zebrafish segmentation clock core circuit |
| Q37809241 | Transcriptional Control of Acinar Development and Homeostasis |
| Q83498615 | Transcriptional characterization of Wnt and Notch signaling pathways in neuronal differentiation of human adipose tissue-derived stem cells |
| Q80406347 | Transcriptional characterization of the Notch signaling pathway in rodent multipotent adult progenitor cells |
| Q33670512 | Transcriptional regulation of the human growth hormone receptor (hGHR) gene V2 promoter by transcriptional activators and repressor |
| Q33905472 | Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. |
| Q52641504 | Transplantation of endothelial progenitor cells attenuated paraquat-induced acute lung injury via miR-141-3p-Notch-Nrf2 axis. |
| Q37129807 | Treatment resistance mechanisms of malignant glioma tumor stem cells |
| Q34329197 | Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis |
| Q42379765 | USP11 regulates PML stability to control Notch-induced malignancy in brain tumours. |
| Q93134156 | Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation |
| Q35040989 | Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants |
| Q89709144 | Whitefly HES1 binds to the intergenic region of Tomato yellow leaf curl China virus and promotes viral gene transcription |
| Q38221361 | Wnt-Notch signalling crosstalk in development and disease. |
| Q33709723 | Wogonin induces retinal neuron-like differentiation of bone marrow stem cells by inhibiting Notch-1 signaling |
| Q39535815 | Xanthohumol decreases Notch1 expression and cell growth by cell cycle arrest and induction of apoptosis in epithelial ovarian cancer cell lines |
| Q27345167 | Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis |
| Q41834079 | miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells |
| Q34101839 | γ-Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence |
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