Loss of the serine protease HTRA1 impairs smooth muscle cells maturation

scientific article published on 03 December 2019

Loss of the serine protease HTRA1 impairs smooth muscle cells maturation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-54807-6
P932PMC publication ID6890777
P698PubMed publication ID31796853

P50authorJuan Rodriguez-VitaQ58774280
P2093author name stringAndreas Fischer
Thomas Korff
Fabian Tetzlaff
Chio Oka
Iris Moll
Eva-Maria Weis
Alexander Prinz
Ralph Klose
P2860cites workHairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding siteQ24309221
Notch3 signaling promotes the development of pulmonary arterial hypertensionQ24310736
Implications of the serine protease HtrA1 in amyloid precursor protein processingQ24523725
NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1Q24650900
Distribution of the serine protease HtrA1 in normal human tissuesQ28204023
HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteinsQ28245903
Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and functionQ28591207
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.Q30378420
Regulation of differentiation of vascular smooth muscle cellsQ30464387
Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteriesQ30486605
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel diseaseQ30492865
CADASIL and CARASIL.Q30861866
Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiationQ33885162
Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cellsQ35584425
High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.Q35668755
Transforming growth factor-β and smooth muscle differentiationQ35852389
Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells.Q36141960
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factorsQ36857288
Serine protease HtrA1 associates with microtubules and inhibits cell migrationQ37275172
Notch signalling in smooth muscle cells during development and diseaseQ37977827
Molecular pathways of notch signaling in vascular smooth muscle cellsQ38003146
The emerging roles of HTRA1 in musculoskeletal disease.Q38090191
Monogenic causes of stroke: now and the futureQ38513520
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.Q39320608
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.Q39592304
The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 proteinQ39673764
Notch3 is necessary for blood vessel integrity in the central nervous systemQ40241434
Notch3 is required for arterial identity and maturation of vascular smooth muscle cellsQ40408474
Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel diseaseQ40847527
Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathyQ41815825
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregatesQ42201998
Smooth muscle 22 alpha maintains the differentiated phenotype of vascular smooth muscle cells by inducing filamentous actin bundling.Q42446293
Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.Q46040272
Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritisQ46579960
Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis.Q52715373
MPDZ promotes DLL4-induced Notch signaling during angiogenesis.Q52721396
Notch3 is essential for regulation of the renal vascular tone.Q54376139
Loss of HtrA1 serine protease induces synthetic modulation of aortic vascular smooth muscle cells.Q55451622
TGFβ, smooth muscle cells and coronary artery disease: a reviewQ60922525
SM22alpha is required for agonist-induced regulation of contractility: evidence from SM22alpha knockout miceQ80227895
Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sitesQ91467754
P433issue1
P304page(s)18224
P577publication date2019-12-03
P1433published inScientific ReportsQ2261792
P1476titleLoss of the serine protease HTRA1 impairs smooth muscle cells maturation
P478volume9

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