| scholarly article | Q13442814 |
| P356 | DOI | 10.1056/NEJMOA0801560 |
| P698 | PubMed publication ID | 19387015 |
| P50 | author | Osamu Onodera | Q45304826 |
| P2093 | author name string | Shoji Tsuji | |
| Tadashi Yamamoto | |||
| Toshiaki Takahashi | |||
| Masatoyo Nishizawa | |||
| Yutaka Yoshida | |||
| Akira Tanaka | |||
| Kunimasa Arima | |||
| Toshio Fukutake | |||
| Takeshi Ikeuchi | |||
| Imaharu Nakano | |||
| Hirotoshi Kawata | |||
| Akinori Miyashita | |||
| Kenju Hara | |||
| Ryozo Kuwano | |||
| Shu-ichi Ikeda | |||
| Akio Yokoseki | |||
| Masato Tamura | |||
| Akihide Koyama | |||
| Atsushi Shiga | |||
| Hiroaki Nozaki | |||
| Mari Ikeda | |||
| Takayo Arisato | |||
| Yutaka Shimoe | |||
| Hiroshi Shiota | |||
| Mikio Hirayama | |||
| Sohei Yanagawa | |||
| P433 | issue | 17 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1729-1739 | |
| P577 | publication date | 2009-04-01 | |
| P1433 | published in | The New England Journal of Medicine | Q582728 |
| P1476 | title | Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. | |
| P478 | volume | 360 |
| Q39383329 | A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review |
| Q89893726 | A Case of Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1 |
| Q53248522 | A Next-Generation Sequencing of the NOTCH3 and HTRA1 Genes in CADASIL Patients. |
| Q43178138 | A conserved activation cluster is required for allosteric communication in HtrA-family proteases. |
| Q48280536 | A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population |
| Q62980703 | A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient |
| Q48406327 | A novel mutation in the HTRA1 gene identified in Chinese CARASIL pedigree |
| Q44395739 | A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). |
| Q87939445 | A role for proteoglycans in vascular disease |
| Q89475149 | A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration |
| Q28504581 | Abnormal development of placenta in HtrA1-deficient mice |
| Q34232310 | Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities. |
| Q30951687 | Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia Caused by a Novel R782G Mutation in CSF1R. |
| Q36826856 | Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. |
| Q39237038 | Allosteric regulation of DegS protease subunits through a shared energy landscape |
| Q34204971 | An autosomal recessive leucoencephalopathy with ischemic stroke, dysmorphic syndrome and retinitis pigmentosa maps to chromosome 17q24.2-25.3. |
| Q38027076 | Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response |
| Q64106545 | Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects |
| Q52684420 | BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. |
| Q30861866 | CADASIL and CARASIL. |
| Q42693620 | COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls |
| Q54479618 | CSF1R mutations identified in three families with autosomal dominantly inherited leukoencephalopathy. |
| Q35598638 | Can proteomics yield insight into aging aorta? |
| Q89641272 | Cerebral small vessel disease due to a unique heterozygous HTRA1 mutation in an African man |
| Q104134943 | Cerebral small vessel disease genomics and its implications across the lifespan |
| Q34581220 | Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling |
| Q28287345 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges |
| Q30574731 | Cerebral small vessel disease: insights and opportunities from mouse models of collagen IV-related small vessel disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| Q39592304 | Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1. |
| Q57456322 | Cerebrovascular disorders associated with genetic lesions |
| Q95840655 | Clinical and Genetic Aspects of CADASIL |
| Q48612790 | Clinical, familial, and neuroimaging features of CADASIL-like patients |
| Q36627110 | Clinical-pathologic correlations in vascular cognitive impairment and dementia |
| Q57185331 | Clustering of multifocal cerebral infarctions in CADASIL: a case report |
| Q55024983 | Connective tissue growth factor (CTGF) in age-related vascular pathologies. |
| Q43149414 | Conversion of a regulatory into a degradative protease |
| Q28067980 | Copy number variations and stroke |
| Q37620563 | Crosstalk between cerebral endothelium and oligodendrocyte |
| Q51888728 | Decidual HtrA3 negatively regulates trophoblast invasion during human placentation. |
| Q42152333 | Determinants of amyloid fibril degradation by the PDZ protease HTRA1. |
| Q43004118 | Determinants of structural and functional plasticity of a widely conserved protease chaperone complex |
| Q48472321 | Disruption of a miR-29 binding site leading to COL4A1 upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy |
| Q34666305 | Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer |
| Q47189539 | ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity |
| Q34452910 | Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration |
| Q90739055 | Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes |
| Q43795438 | Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling |
| Q37643585 | Endothelial cell-oligodendrocyte interactions in small vessel disease and aging |
| Q36224858 | Generation and characterization of mice with a conditional null allele of the HtrA4 gene. |
| Q93102418 | Genetic Factors of Cerebral Small Vessel Disease and Their Potential Clinical Outcome |
| Q28079249 | Genetic Risk Factors for Ischemic and Hemorrhagic Stroke |
| Q38433566 | Genetic factors in cerebral small vessel disease and their impact on stroke and dementia |
| Q34522989 | Genetic stroke syndromes |
| Q28076438 | Genetic susceptibility to cerebrovascular disease |
| Q30414709 | Genetic susceptibility to ischemic stroke |
| Q95644037 | Genetically confirmed CARASIL: A case report with a novel HTRA1 mutation and literature review |
| Q39167599 | Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders. |
| Q35094704 | Genetics of Vascular Dementia |
| Q34565573 | Genetics of age-related macular degeneration: current concepts, future directions |
| Q35076464 | Genetics of cerebral small vessel disease |
| Q39429524 | Genetics of ischaemic stroke |
| Q34555157 | Genetics of ischemic stroke |
| Q37998525 | Genetics of ischemic stroke, stroke-related risk factors, stroke precursors and treatments |
| Q37843432 | HTRA proteases: regulated proteolysis in protein quality control |
| Q35048990 | HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular d |
| Q91971363 | HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade |
| Q92113129 | HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression |
| Q88581388 | HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1 |
| Q98893484 | Heritability for stroke: Essential for taking family history |
| Q52644904 | Heterozygous HTRA1 missense mutation in CADASIL-like family disease. |
| Q40847527 | Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease |
| Q38637727 | Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease. |
| Q35668755 | High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. |
| Q51499978 | Histopathologic Analysis of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL): A Report of a New Genetically Confirmed Case and Comparison to 2 Previous Cases. |
| Q43632795 | HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication. |
| Q38458788 | HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8. |
| Q93187659 | HtrA1 upregulates the expression of ADAMTS-5 in HNPCs via the ERK/NF-κB/JNK signaling pathway |
| Q42201998 | Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates |
| Q90435842 | Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease |
| Q35008186 | Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease |
| Q27319555 | Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice |
| Q52715373 | Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis. |
| Q35197893 | Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice |
| Q37173083 | Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity |
| Q38151888 | Is overactive bladder a brain disease? The pathophysiological role of cerebral white matter in the elderly |
| Q41873256 | LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1 |
| Q55451622 | Loss of HtrA1 serine protease induces synthetic modulation of aortic vascular smooth muscle cells. |
| Q43228018 | Loss of HtrA1-induced attenuation of TGF-β signaling in fibroblasts might not be the main mechanism of CARASIL pathogenesis. |
| Q91657393 | Loss of the serine protease HTRA1 impairs smooth muscle cells maturation |
| Q50357305 | MRI pattern approach of adult-onset inherited leukoencephalopathies |
| Q33870606 | Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood. |
| Q51762755 | Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. |
| Q89617431 | Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit |
| Q26824027 | Microvascular pathology and morphometrics of sporadic and hereditary small vessel diseases of the brain |
| Q89287820 | Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke |
| Q50531000 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. |
| Q64075636 | Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment |
| Q35140102 | Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease |
| Q26750515 | Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease |
| Q34664010 | New information on the genetics of stroke |
| Q94414989 | Non–Registered Abstracts |
| Q92557960 | Novel mutation in HTRA1 in a family with diffuse white matter lesions and inflammatory features |
| Q39261579 | Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs |
| Q28741873 | Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components |
| Q37846935 | Paediatric stroke: genetic insights into disease mechanisms and treatment targets |
| Q48194042 | Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion |
| Q36593214 | Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain? |
| Q38731149 | Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations. |
| Q55266481 | Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease. |
| Q91669321 | Proteostasis in Cerebral Small Vessel Disease |
| Q28542717 | Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease |
| Q37808273 | Review: molecular genetics and pathology of hereditary small vessel diseases of the brain. |
| Q38696646 | Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation. |
| Q33559303 | Roles of tau protein in health and disease |
| Q34571315 | Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits |
| Q34989757 | Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation |
| Q38004977 | Single gene disorders associated with stroke: a review and update on treatment options |
| Q53827519 | Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. |
| Q33822183 | Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1 |
| Q30238633 | Stroke Risk Factors, Genetics, and Prevention |
| Q37915080 | Stroke genetics |
| Q36786383 | Stroke injury, cognitive impairment and vascular dementia |
| Q59360358 | Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa |
| Q27666671 | Substrate-induced remodeling of the active site regulates human HTRA1 activity |
| Q30378420 | Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling. |
| Q48963606 | TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of magnetic resonance imaging follow-up |
| Q33792759 | The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain |
| Q53361611 | The first Greek case of heterozygous cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy: An atypical clinico-radiological presentation. |
| Q38969718 | The impact of cerebrovascular aging on vascular cognitive impairment and dementia. |
| Q34544980 | The pathobiology of vascular malformations: insights from human and model organism genetics |
| Q35175576 | The small leucine-rich proteoglycan BGN accumulates in CADASIL and binds to NOTCH3 |
| Q47557347 | Two novel heterozygous HTRA1 mutations in two pedigrees with cerebral small vessel disease families. |
| Q33538069 | Unravelling the genetics of ischaemic stroke |
| Q47964631 | Update on Vascular Dementia |
| Q51811743 | Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes. |
| Q33967781 | Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association |
| Q36375655 | Vascular incontinence: incontinence in the elderly due to ischemic white matter changes |
| Q103836788 | Whole-exome sequencing of Finnish patients with vascular cognitive impairment |
| Q84743860 | [Vasculitis and hereditary small vessel diseases] |
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