Tyrosine phosphorylation of transmembrane ligands for Eph receptors

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Tyrosine phosphorylation of transmembrane ligands for Eph receptors is …
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scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.275.5306.1640
P698PubMed publication ID9054357

P2093author name stringPasquale EB
Klein R
Brückner K
P2860cites workMolecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase HtkQ24563938
Protein modules and signalling networksQ27860694
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptorsQ28235378
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activityQ28241585
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligandsQ28294023
Nuk controls pathfinding of commissural axons in the mammalian central nervous systemQ28507318
Recognition and specificity in protein tyrosine kinase-mediated signallingQ30192978
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinasesQ34058301
ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming SomitesQ36554495
Molecular cloning of two novel transmembrane ligands for Eph-related kinases (LERKS) that are related to LERK-2.Q36819446
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGFQ37594719
Telling axons where to grow: a role for Eph receptor tyrosine kinases in guidanceQ41064982
Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivoQ41168628
Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabledQ41870117
Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiationQ43472020
Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual systemQ46595809
Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrainQ47073986
Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrainQ48081442
A phosphotyrosine interaction domainQ56918691
P433issue5306
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
transmembrane proteinQ424204
P304page(s)1640-1643
P577publication date1997-03-01
P1433published inScienceQ192864
P1476titleTyrosine phosphorylation of transmembrane ligands for Eph receptors
P478volume275

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cites work (P2860)
Q38294790Activation of EphB2 and Its Ligands Promotes Vascular Smooth Muscle Cell Proliferation
Q30476909Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.
Q41755556Adhesion and signaling in axonal fasciculation
Q40846241An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein.
Q39714662Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion
Q36775227Axon Guidance Molecules and Neural Circuit Remodeling After Spinal Cord Injury.
Q34560919Axon guidance: the cytoplasmic tail
Q28592877Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice
Q36682364Bidirectional ephrin/Eph signaling in synaptic functions
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Q48030369Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers
Q28211031Coexpression of ephrin-Bs and their receptors in colon carcinoma
Q47892353Comparative analysis of embryonic gene expression defines potential interaction sites for Xenopus EphB4 receptors with ephrin-B ligands
Q24596866Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
Q40526435Computational modeling of retinotopic map development to define contributions of EphA-ephrinA gradients, axon-axon interactions, and patterned activity
Q34621016Constructing the hindbrain: insights from the zebrafish
Q35181668Contact-dependent signaling during the late events of platelet activation.
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Q39657563Control of skeletal patterning by ephrinB1-EphB interactions
Q27637196Crystal structure of an Eph receptor–ephrin complex
Q27766349Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2
Q28757871Development and differentiation of the intestinal epithelium
Q61642389Development and reorganization of corticospinal projections in EphA4 deficient mice
Q52541281Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone
Q74476975Distribution of Eph-related molecules in the developing and mature cochlea
Q34872708Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis
Q28590093Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail
Q31813080Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction
Q36694994Effects of overexpression of ephrin-B2 on tumour growth in human colorectal cancer
Q92106745Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
Q37996166Emerging zoonotic viruses: new lessons on receptor and entry mechanisms
Q38008492Eph and ephrins in epithelial stem cell niches and cancer.
Q36125059Eph receptor and ephrin function in breast, gut, and skin epithelia
Q29619988Eph receptor signalling casts a wide net on cell behaviour
Q92578208Eph receptor signalling: from catalytic to non-catalytic functions
Q34103639Eph receptors and ephrin ligands: embryogenesis to tumorigenesis
Q21328694Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis
Q37271460Eph receptors and ephrin signaling pathways: a role in bone homeostasis
Q35370195Eph receptors and ephrins as targets for cancer therapy
Q33540120Eph receptors and ephrins in neural development.
Q52165682Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration.
Q48164807Eph receptors and ephrins restrict cell intermingling and communication
Q28139507Eph receptors and ephrins: regulators of guidance and assembly
Q24316974Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
Q24596675Eph signaling is required for segmentation and differentiation of the somites
Q38209232Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics
Q42492492Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes
Q37971902Eph-dependent cell-cell adhesion and segregation in development and cancer.
Q39881917Eph-ephrin bidirectional signaling comes into the context of lymphocyte transendothelial migration
Q37971530Eph/ephrin signaling in cell-cell and cell-substrate adhesion.
Q37087056Eph/ephrin signaling: networks.
Q34980169EphA activation overrides the presynaptic actions of BDNF
Q28588637EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract
Q48621196EphA4 is not required for Purkinje cell compartmentation
Q46779394EphA4 misexpression alters tonotopic projections in the auditory brainstem.
Q44092257EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping
Q80193034EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord
Q52113102EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers
Q28141518EphB receptors interact with NMDA receptors and regulate excitatory synapse formation
Q54564139EphB/ephrin-B interaction mediates adult stem cell attachment, spreading, and migration: implications for dental tissue repair.
Q35039009EphB/ephrinB signaling in cell adhesion and migration
Q24306491EphB1 associates with Grb7 and regulates cell migration
Q28508539EphB2 guides axons at the midline and is necessary for normal vestibular function
Q46080583EphB2 regulates axonal growth at the midline in the developing auditory brainstem.
Q48370712EphB3 receptor and ligand expression in the adult rat brain
Q44390853EphB4 receptor tyrosine kinase transgenic mice develop glomerulopathies reminiscent of aglomerular vascular shunts
Q48913032Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis.
Q37658786Ephrin expression and function in cancer.
Q39356254Ephrin ligands and Eph receptors contribution to hematopoiesis
Q34229381Ephrin reverse signaling in axon guidance and synaptogenesis.
Q41040325Ephrin reverse signaling mediates palatal fusion and epithelial-to-mesenchymal transition independently of Tgfß3.
Q28199521Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum
Q40430352Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
Q28212190Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction
Q30477865Ephrin-B reverse signaling is required for formation of strictly contralateral auditory brainstem pathways
Q40653046Ephrin-B1 Reverse Signaling Activates JNK through a Novel Mechanism That Is Independent of Tyrosine Phosphorylation
Q28504499Ephrin-B1 forward and reverse signaling are required during mouse development
Q37247119Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism
Q47659849Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats.
Q35842907Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development
Q28143384Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6
Q38801727Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors
Q24652692Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning
Q54575179Ephrin-Mediated cis-Attenuation of Eph Receptor Signaling Is Essential for Spinal Motor Axon Guidance
Q40716314EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).
Q22009170EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
Q28647621EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase
Q37317736EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.
Q37267167EphrinB reverse signaling in cell-cell adhesion: is it just par for the course?
Q37038281EphrinB1 controls cell-cell junctions through the Par polarity complex
Q34073875EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation
Q48678723EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4
Q38842539EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease.
Q38112820Ephrins and pain
Q34612363Ephrins are not only unattractive
Q34788609Ephrins in reverse, park and drive
Q44569763Ephs and ephrins during early stages of chick embryogenesis
Q34031959Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis
Q34132914Excitation at the synapse: Eph receptors team up with NMDA receptors
Q46017724Expression and Tyrosine Phosphorylation of Eph Receptors Suggest Multiple Mechanisms in Patterning of the Visual System
Q24799713Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells
Q44889618Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem
Q37035190Fibroblast growth factor receptor-induced phosphorylation of ephrinB1 modulates its interaction with Dishevelled
Q33961672Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryos
Q28593928Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline
Q58803214Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats
Q49841689Getting direction(s): The Eph/ephrin signaling system in cell positioning
Q46044022Graded and Lamina-Specific Distributions of Ligands of EphB Receptor Tyrosine Kinases in the Developing Retinotectal System
Q33814336Growth factor signaling pathways in vascular development
Q34013847Heparin-binding EGF-like growth factor: a juxtacrine growth factor
Q28640598Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain
Q63487520How attraction turns to repulsion
Q39471091Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometry
Q24647476Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma
Q48195215In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
Q30996386In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue
Q38270107Inhibiting Eph kinase activity may not be "Eph"ective for cancer treatment.
Q24313265Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases
Q34770033Inhibition of tumor growth and angiogenesis by soluble EphB4.
Q33534704Inhibitory interactions in the patterning of trunk neural crest migration
Q43151071Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.
Q36521957Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.
Q45298958Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
Q83333021Intramyocardial administration of chimeric ephrinA1-Fc promotes tissue salvage following myocardial infarction in mice
Q31965129Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.
Q46327899Lerk2 (Ephrin-B1) Is a Collapsing Factor for a Subset of Cortical Growth Cones and Acts by a Mechanism Different from AL-1 (Ephrin-A5)
Q57351863Long-decay near-infrared-emitting doped quantum dots for lifetime-based in vivo pH imaging
Q35739762Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand.
Q44795517Loss-of-function analysis of EphA receptors in retinotectal mapping.
Q35817738Low EphA7 Expression Correlated with Lymph Node Metastasis and Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma
Q52184226MINI‐REVIEW The Eph receptor tyrosine kinases and the ephrins – roles in nervous system development
Q28208291Mechanisms and functions of Eph and ephrin signalling
Q36294315Mechanisms of axon guidance in the developing nervous system.
Q38704281Mechanisms of ephrin-Eph signalling in development, physiology and disease.
Q37643632Membrane-mediated regulation of vascular identity.
Q24336334Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4
Q35645904Molecular Mechanisms of Cell Segregation and Boundary Formation in Development and Tumorigenesis
Q90396198Molecular complexity of visual mapping: a challenge for regenerating therapy
Q46612706Molecular development of sensory maps: representing sights and smells in the brain
Q36395767Molecular mechanisms of axon guidance
Q44728323Morphogenetic movements underlying eye field formation require interactions between the FGF and ephrinB1 signaling pathways.
Q34134031Motor axon pathfinding in the peripheral nervous system.
Q73353794Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor
Q28205325Multiple roles of EPH receptors and ephrins in neural development
Q36827349Navigating their way to the clinic: emerging roles for axon guidance molecules in neurological disorders and injury
Q24554304Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
Q90283008Nck2 is essential for limb trajectory selection by spinal motor axons
Q38655963Near infrared quantum dots in biomedical applications: current status and future perspective
Q28588264Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins
Q28585766Neurexin mediates the assembly of presynaptic terminals
Q33796246New paradigms of signaling in the vasculature: ephrins and metalloproteases
Q24629619Non-SH2/PDZ reverse signaling by ephrins
Q49126404Nurr1 co-localizes with EphB1 receptors in the developing ventral midbrain, and its expression is enhanced by the EphB1 ligand, ephrinB2.
Q41045322Oligomerization of the extracellular domain of Boss enhances its binding to the Sevenless receptor and its antagonistic effect on R7 induction
Q38261392One shall become two: Separation of the esophagus and trachea from the common foregut tube
Q28585965PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
Q22008644PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands
Q39250638Phosphatase and tensin homolog regulates stability and activity of EphB1 receptor
Q33839571Phosphoproteome Profiling Using a Fluorescent Phosphosensor Dye in Two-Dimensional Polyacrylamide Gel Electrophoresis
Q34116905Phosphorylation of ephrin-B1 via the interaction with claudin following cell-cell contact formation
Q28647596Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors
Q39108606Proteomics Analysis of Contact-Initiated Eph Receptor–Ephrin Signaling
Q36301542R4 RGS proteins: regulation of G-protein signaling and beyond
Q28083779Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time
Q48022328Reduced blood pressure after smooth muscle EFNB2 deletion and the potential association of EFNB2 mutation with human hypertension risk
Q36718369Regulation of neural progenitor cell state by ephrin-B
Q28258431Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Q40445775Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways
Q91918873Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation
Q24676243Roles of Eph receptors and ephrins in segmental patterning
Q58805400Roles of Eph/ephrin bidirectional signaling during injury and recovery of the central nervous system
Q49884500Roles of Eph/ephrin bidirectional signaling in central nervous system injury and recovery
Q24608892Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
Q42843392Rüdiger Klein: reading the guideposts for axon guidance. Interview by Caitlin Sedwick.
Q28263026Should I stay or should I go? Ephs and ephrins in neuronal migration
Q47754321Signaling by Eph receptors and their ephrin ligands
Q34300573Signaling downstream of Eph receptors and ephrin ligands
Q39966454Signaling through ephrin-A ligand leads to activation of Src-family kinases, Akt phosphorylation, and inhibition of antigen receptor-induced apoptosis.
Q35610287Signalling mechanisms mediating neuronal responses to guidance cues
Q44850885Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein
Q36812361Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction
Q27620261Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites
Q38503847Specific and shared targets of ephrin A signaling in epidermal keratinocytes
Q27635000Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region
Q33178119Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins
Q28145776Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
Q58699700TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
Q36642255The CNS synapse revisited: gaps, adhesive welds, and borders
Q28270171The Eph Family Receptors and Ligands
Q41651168The Eph family in the patterning of neural development
Q28251298The Eph family of receptors
Q52193318The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
Q24291347The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner
Q28216283The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals
Q28264908The VAB-1 Eph Receptor Tyrosine Kinase Functions in Neural and Epithelial Morphogenesis in C. elegans
Q28295434The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
Q41587560The eph receptor family:axonal guidance by contact repulsion
Q28141789The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans
Q28212424The ephrins and Eph receptors in angiogenesis
Q28266706The ephrins and Eph receptors in neural development
Q48386317The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation
Q24290271The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain
Q47273883Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers
Q37682986To phosphorylate or not to phosphorylate: Selective alterations in tyrosine kinase-inhibited EphB mutant mice
Q33960688Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B ligands
Q47847606Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression
Q28278050Transmembrane Neuregulins Interact with LIM Kinase 1, a Cytoplasmic Protein Kinase Implicated in Development of Visuospatial Cognition
Q43559492Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism.
Q56338204Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS)
Q41972837Tyr-298 in ephrinB1 is critical for an interaction with the Grb4 adaptor protein.
Q36646778Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids
Q64062178Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies
Q47964362Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border
Q46115575Voltage-Dependent Activation of Frog Eggs by a Sperm Surface Disintegrin Peptide
Q36141386ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3.

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