Multiple roles of EPH receptors and ephrins in neural development

scientific article (publication date: March 2001)

Multiple roles of EPH receptors and ephrins in neural development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1046163488
P356DOI10.1038/35058515
P3181OpenCitations bibliographic resource ID4341848
P698PubMed publication ID11256076

P50authorDavid WilkinsonQ42712968
P2860cites workRoles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibersQ73555171
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligandsQ22008644
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomainsQ22009170
Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activityQ22010573
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylationQ22011187
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responsesQ24316974
Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinaseQ24320914
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4Q24336334
Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptorsQ24532216
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cellsQ24532273
Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activationQ24554304
Eph signaling is required for segmentation and differentiation of the somitesQ24596675
Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesionQ24596866
Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal systemQ24598982
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisQ24608892
Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastomaQ24647476
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptorQ24676972
Cell signaling by receptor tyrosine kinasesQ27860474
An early developmental role for eph-ephrin interaction during vertebrate gastrulationQ28138024
Multiple in vivo tyrosine phosphorylation sites in EphB receptorsQ28138528
Eph receptors and ephrins: regulators of guidance and assemblyQ28139507
EphB receptors interact with NMDA receptors and regulate excitatory synapse formationQ28141518
The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegansQ28141789
Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responsesQ28143168
Regulated cleavage of a contact-mediated axon repellentQ28144522
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular developmentQ28145776
Regulation of learning by EphA receptors: a protein targeting studyQ28146027
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activityQ28241585
Roles of Eph receptors and ephrins in neural crest pathfindingQ28250439
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegansQ28264908
The ephrins and Eph receptors in neural developmentQ28266706
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase betaQ28269278
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane regionQ28274112
Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactionsQ28277260
Segmentation in the chick embryo hindbrain is defined by cell lineage restrictionsQ28280395
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesisQ28286738
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesisQ28287785
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligandsQ28294023
Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection mapQ28295221
The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motifQ28295434
Dual action of a ligand for Eph receptor tyrosine kinases on specific populations of axons during the development of cortical circuitsQ28505162
A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1AQ28507307
Nuk controls pathfinding of commissural axons in the mammalian central nervous systemQ28507318
EphB2 guides axons at the midline and is necessary for normal vestibular functionQ28508539
The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brainQ28567260
Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axonsQ48219540
Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual systemQ48517864
AL-1-induced growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeletonQ48806871
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.Q52169064
The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells.Q52193318
Disruption of cell adhesion in Xenopus embryos by Pagliaccio, an Eph-class receptor tyrosine kinase.Q52199338
Control of topographic retinal axon branching by inhibitory membrane-bound molecules.Q52882516
Masking of Eph receptors and ephrinsQ63487527
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptorQ73353794
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formationQ28588287
EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tractQ28588637
Topographic guidance labels in a sensory projection to the forebrainQ28589074
Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalkQ28589209
Regulation of repulsion versus adhesion by different splice forms of an Eph receptorQ28589811
Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinaseQ28647593
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptorsQ28647596
The molecular biology of axon guidanceQ29617857
Cadherin cell adhesion receptors as a morphogenetic regulatorQ29620503
Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrinsQ33178119
Shared and distinct functions of RAGS and ELF-1 in guiding retinal axonsQ33886245
Control of cell behaviour by signalling through Eph receptors and ephrins.Q33941577
Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryosQ33961672
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinasesQ34058301
Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand.Q35739762
Regulation of thalamic neurite outgrowth by the Eph ligand ephrin-A5: implications in the development of thalamocortical projectionsQ36069998
Ephrin-dependent growth and pruning of hippocampal axonsQ36457677
Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinaseQ36826064
Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent mannerQ40430352
Receptor protein-tyrosine kinases and their signal transduction pathwaysQ40611453
The EphA4 receptor tyrosine kinase is necessary for the guidance of nasal retinal ganglion cell axons in vitroQ40841430
A mapping label required for normal scale of body representation in the cortexQ40892578
Segregation of the receptor EphA7 from its tyrosine kinase-negative isoform on neurons in adult mouse brainQ40905101
Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5.Q41120720
Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivoQ41168628
Ephrins and their receptors: a repulsive topic?Q41605984
Isolation and characterization of Dek, a Drosophila eph receptor protein tyrosine kinaseQ41669736
Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signalingQ41752889
Ephrin-B regulates the Ipsilateral routing of retinal axons at the optic chiasmQ42025303
Tyrosine phosphorylation of transmembrane ligands for Eph receptorsQ42802862
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration.Q45967946
Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system.Q46017724
Graded and lamina-specific distributions of ligands of EphB receptor tyrosine kinases in the developing retinotectal systemQ46044022
Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowthQ46218122
Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retinaQ46373459
Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual systemQ46595809
Effects of mesodermal tissues on avian neural crest cell migration.Q46644219
Regulation of hippocampal synaptic plasticity by the tyrosine kinase receptor, REK7/EphA5, and its ligand, AL-1/Ephrin-A5.Q46762460
Signaling by Eph receptors and their ephrin ligandsQ47754321
Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesisQ48058495
Eph receptors and ephrins restrict cell intermingling and communicationQ48164807
Neural crest development in the Xenopus laevis embryo, studied by interspecific transplantation and scanning electron microscopyQ48186610
In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrinsQ48195215
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)155-64
P577publication date2001-03-01
P1433published inNature Reviews NeuroscienceQ2108225
P1476titleMultiple roles of EPH receptors and ephrins in neural development
P478volume2

Reverse relations

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Q52016001Peters anomaly in association with multiple midline anomalies and a familial chromosome 4 inversion.
Q33656642Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation
Q89909205Possible role of EphA4 and VEGFR2 interactions in neural stem and progenitor cell differentiation
Q57492342Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer's Disease
Q39634533Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions
Q42589449Pretarget sorting of retinocollicular axons in the mouse
Q55070097Prognostic role of EphA2 in various human carcinomas: a meta-analysis of 23 related studies.
Q34465671Proteomic analysis of fibroblastema formation in regenerating hind limbs of Xenopus laevis froglets and comparison to axolotl
Q34230386Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
Q35801848Rapid Changes in Cortical and Subcortical Brain Regions after Early Bilateral Enucleation in the Mouse
Q28114923Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
Q90395264Receptor Tyrosine Kinase EphB3: a Prognostic Indicator in Colorectal Carcinoma
Q24337391Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon
Q35068992Regulation of axial patterning of the retina and its topographic mapping in the brain.
Q36677781Regulation of ephrin-A expression in compressed retinocollicular maps
Q28504714Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1
Q38465004Regulation of intestinal stem cell fate specification
Q35002087Reverse signaling by glycosylphosphatidylinositol-linked Manduca ephrin requires a SRC family kinase to restrict neuronal migration in vivo.
Q40855885Reverse signaling via a glycosyl-phosphatidylinositol-linked ephrin prevents midline crossing by migratory neurons during embryonic development in Manduca
Q41456188Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonal projection
Q26860972Role of Eph/ephrin tyrosine kinase in malignant glioma
Q58805400Roles of Eph/ephrin bidirectional signaling during injury and recovery of the central nervous system
Q49884500Roles of Eph/ephrin bidirectional signaling in central nervous system injury and recovery
Q37584993Roles of EphA2 in Development and Disease
Q52640725Segment boundary formation inDrosophilaembryos
Q28263026Should I stay or should I go? Ephs and ephrins in neuronal migration
Q28210262Signals from Eph and ephrin proteins: a developmental tool kit
Q35961070Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts
Q30482224Slits and Robos in the developing chicken inner ear
Q37835197Spatiotemporal changes in cell adhesiveness during vertebrate limb morphogenesis
Q47444122Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map.
Q45142298Stem cell factor is a chemoattractant and a survival factor for CNS stem cells
Q38859228Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β.
Q35423979Strain-dependent up-regulation of ephrin-B2 protein in periodontal ligament fibroblasts contributes to osteogenesis during tooth movement
Q37120225Structural and molecular micropatterning of dual hydrogel constructs for neural growth models using photochemical strategies.
Q27650639Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2
Q42222519Superimposed topographic and chemical cues synergistically guide neurite outgrowth.
Q28219424SynCAM, a synaptic adhesion molecule that drives synapse assembly
Q95936543Synergistic antifibrotic effects of miR-451 with miR-185 partly by co-targeting EphB2 on hepatic stellate cells
Q38637516Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal-Retzius cells
Q28593557Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice
Q35190712Thalamocortical topography reloaded: it's not where you go, but how you get there.
Q22337378The Contribution of the Neural Crest to the Vertebrate Body
Q37810999The Dynamic Glycome Microenvironment and Stem Cell Differentiation into Vasculature
Q36832243The Effect of Chemoradiotherapy with SRC Tyrosine Kinase Inhibitor, PP2 and Temozolomide on Malignant Glioma Cells In Vitro and In Vivo
Q28585285The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells
Q28591838The L1 cell adhesion molecule is essential for topographic mapping of retinal axons
Q38372245The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors
Q35860836The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease
Q28391620The Role of PTEN in Tumor Angiogenesis
Q36341388The development of retinotectal maps: a review of models based on molecular gradients.
Q36500579The gap junction cellular internet: connexin hemichannels enter the signalling limelight
Q92548222The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
Q28535407The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression
Q30663428The limits of chemosensation vary across dimensions
Q35079901The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord
Q34598154The role of Rho GTPases and associated kinases in regulating neurite outgrowth
Q47069351The roles of an ephrin and a semaphorin in patterning cell-cell contacts in C. elegans sensory organ development
Q35849505The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
Q37475582Theoretical models of neural circuit development.
Q28278384Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons
Q33960688Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B ligands
Q52584177Topographic specificity within membranes of a single muscle detected in vitro.
Q34245285Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains
Q30495861Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum
Q45348722Two specific populations of GABAergic neurons originating from the medial and the caudal ganglionic eminences aid in proper navigation of callosal axons
Q36793426WNT signaling underlies the pathogenesis of neuropathic pain in rodents
Q35937586Wiring the vascular circuitry: from growth factors to guidance cues

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