EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target

scientific article published on June 1, 2012

EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CBT.20080
P953full work available online athttps://www.tandfonline.com/doi/pdf/10.4161/cbt.20080?needAccess=true
P698PubMed publication ID22555806

P2093author name stringBahija Jallal
Zhan Xiao
Rosa Carrasco
Steve Coats
Darrin Sabol
Krista Kinneer
David A. Tice
P2860cites workActivation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylationQ22011187
Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cellsQ24301457
EphB4 expression and biological significance in prostate cancerQ24304334
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and AktQ24318755
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingQ24532278
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular developmentQ28145776
Bidirectional Eph-ephrin signaling during axon guidanceQ28297294
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sitesQ28609103
Eph-ephrin bidirectional signaling in physiology and diseaseQ29617975
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retractionQ31813080
Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemiaQ33482013
Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemiaQ33754623
Eph receptors and ephrins in cancer: bidirectional signalling and beyondQ34021365
Inhibition of tumor growth and angiogenesis by soluble EphB4.Q34770033
Receptor tyrosine kinase EphB4 is a survival factor in breast cancerQ35221906
The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growthQ35849505
EphB/EphrinB receptors and Wnt signaling in colorectal cancerQ36362266
The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcomeQ36610209
Paradoxes of the EphB4 receptor in cancerQ36812751
Cell-cell signaling via Eph receptors and ephrinsQ36967529
Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progressionQ39861032
EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.Q40074110
EPHB4 and survival of colorectal cancer patients.Q40230554
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathwayQ40252238
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymesQ40359711
EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphataseQ40392006
EphB receptor activity suppresses colorectal cancer progressionQ40405920
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectMAP kinase signaling systemQ71130435
P304page(s)630-637
P577publication date2012-06-01
P1433published inCancer Biology and TherapyQ2544651
P1476titleEphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target
P478volume13

Reverse relations

cites work (P2860)
Q45355262Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia
Q41828383Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4.
Q57176106BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells
Q41821364Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4
Q55286883Differential Expression Patterns of Eph Receptors and Ephrin Ligands in Human Cancers.
Q38109928Druggable Orthosteric and Allosteric Hot Spots to Target Protein-protein Interactions
Q90883711EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells
Q37122330Eph receptor signaling and ephrins
Q38209232Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics
Q55512730Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death.
Q37448572EphB4 tyrosine kinase stimulation inhibits growth of MDA-MB-231 breast cancer cells in a dose and time dependent manner.
Q49709391EphB4: A promising target for upper aerodigestive malignancies
Q35536905Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.
Q38842539EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease.
Q27852191Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.
Q42352727Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Q37643632Membrane-mediated regulation of vascular identity.
Q52595509Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study.
Q89636636Pumping the brakes on RAS - negative regulators and death effectors of RAS
Q90744589Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation
Q89721920The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2
Q38174793Therapeutic targeting of EPH receptors and their ligands

Search more.