Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

scientific article

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2009-05-222208
P932PMC publication ID2845899
P698PubMed publication ID20061560
P5875ResearchGate publication ID40899300

P50authorGuillermo Garcia-ManeroQ66385413
P2093author name stringHui Yang
Gonzalo Lopez
Hao Bai
Shao-Qing Kuang
Zack Z Wang
Weigang Tong
Zhi-Hong Fang
P2860cites workThe protein kinase complement of the human genomeQ24324497
Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastomaQ24647476
Mechanisms and functions of Eph and ephrin signallingQ28208291
Tumor suppressor functions of ARLTS1 in lung cancersQ28240843
Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature CommitteeQ28246847
The role of ephrins and Eph receptors in cancerQ28294851
Ephrin-B3 ligand promotes glioma invasion through activation of Rac1.Q33256258
Differential gene expression of Eph receptors and ephrins in benign human tissues and cancersQ34290211
Silencing of bidirectional promoters by DNA methylation in tumorigenesisQ34527442
PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cellsQ35785713
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.Q39975102
EPHB4 and survival of colorectal cancer patients.Q40230554
Differential tumor suppressor properties and transforming growth factor-beta responsiveness of p57KIP2 in leukemia cells with aberrant p57KIP2 promoter DNA methylationQ40238946
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathwayQ40252238
Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines.Q40309042
Transcriptional silencing of EphB6 receptor tyrosine kinase in invasive breast carcinoma cells and detection of methylated promoter by methylation specific PCR.Q40338689
Downregulation of EphA7 by hypermethylation in colorectal cancerQ40399375
EphB receptor activity suppresses colorectal cancer progressionQ40405920
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancerQ40527387
Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cellsQ40740770
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skinQ42498441
Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancerQ42498631
EphA2 overexpression causes tumorigenesis of mammary epithelial cells.Q43561178
Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.Q46803723
Eph-ephrin promiscuity is now crystal clearQ47683124
Signaling by Eph receptors and their ephrin ligandsQ47754321
Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.Q53338659
Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping.Q54295585
Eph receptors and ephrinsQ78651291
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
DNA methylationQ874745
lymphoblastic leukemiaQ18553852
P304page(s)2412-2419
P577publication date2010-01-08
P1433published inBloodQ885070
P1476titleAberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia
P478volume115

Reverse relations

cites work (P2860)
Q41853631A role for DNA methylation in regulation of EphA5 receptor expression in the mouse retina
Q45355262Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia
Q35118861Association of secondhand smoke exposures with DNA methylation in bladder carcinomas.
Q36498110C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.
Q39094566DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia.
Q51499838DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma.
Q40059586Differential gene expression profiling linked to tumor progression of splenic marginal zone lymphoma
Q35003666Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics
Q35017605Downregulation of EphA5 by promoter methylation in human prostate cancer
Q92106745Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
Q38209232Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics
Q37971902Eph-dependent cell-cell adhesion and segregation in development and cancer.
Q26864082EphA receptor signaling--complexity and emerging themes
Q51808808EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells.
Q37190444EphA8 is a prognostic marker for epithelial ovarian cancer
Q38878649EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System
Q36179161EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion
Q39354035EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target
Q39445033EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability
Q38141135Epigenetic regulation of cell signaling pathways in acute lymphoblastic leukemia
Q37965026Epigenetic regulation of miRNA genes in acute leukemia.
Q38297582Epigenetic roots of immunologic disease and new methods for examining chromatin regulatory pathways
Q54211664Expression of Eph A4, Eph B2 and Eph B4 receptors in AML.
Q36618553FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.
Q26852415Functional genomics lead to new therapies in follicular lymphoma
Q37377916Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma
Q35528643High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse
Q42394189Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia
Q37452286Loss of expression of EphB1 protein in serous carcinoma of ovary associated with metastasis and poor survival
Q38336376Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer
Q60921273Methylation of the first exon in the erythropoietin receptor gene does not correlate with its mRNA and protein level in cancer cells
Q38460190Mining for novel tumor suppressor genes using a shortest path approach
Q34256273Mining the cancer genome uncovers therapeutic activity of EphA7 against lymphoma.
Q58130251New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies
Q37637014Next generation sequencing: advances in characterizing the methylome
Q36396570NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer
Q36881958PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
Q37633690Paradoxes of the EphB1 receptor in malignant brain tumors.
Q34364217Peritumoral small ephrinA5 isoform level predicts the postoperative survival in hepatocellular carcinoma
Q92979168Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma
Q38327984Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia.
Q38008491Regulation and misregulation of Eph/ephrin expression
Q39350173Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis
Q36081601Single- and Bayesian Multi-Marker Genome-Wide Association for Haematological Parameters in Pigs.
Q24294856The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma
Q57286200The modular network structure of the mutational landscape of Acute Myeloid Leukemia
Q39481878The putative tumor suppressor gene EphA7 is a novel BMI-1 target
Q38174793Therapeutic targeting of EPH receptors and their ligands
Q49565598lncRNA BC005927 upregulates EPHB4 and promotes gastric cancer metastasis under hypoxia