Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling is …
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P356DOI10.1042/0264-6021:3530417
10.1042/BJ3530417
P8608Fatcat IDrelease_tlilrry3prdkdlqkvyqwwdj27u
P3181OpenCitations bibliographic resource ID634984
P932PMC publication ID1221586
P698PubMed publication ID11171037

P50authorVeerle JanssensQ42184056
P2093author name stringJ Goris
P2860cites workThe structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifsQ22001450
Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2AQ22008557
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2AQ22009542
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologueQ22010935
PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cellsQ22011045
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinQ22253256
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing heartsQ22254160
The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKRQ22254335
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2AQ24310186
A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factorQ24310622
Alpha 4 associates with protein phosphatases 2A, 4, and 6Q24310812
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasmQ24312201
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-cateninQ24313571
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoformQ24315744
Identification of a new family of protein phosphatase 2A regulatory subunitsQ24315781
Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicingQ24316272
The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivoQ24316512
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 betaQ24319688
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaBQ24321775
A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleusQ24321963
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscleQ24336379
Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirusQ24337360
Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.Q24522790
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunitsQ24529840
Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegenerationQ24530141
Functional analysis of the promoter region of the human phosphotyrosine phosphatase activator gene: Yin Yang 1 is essential for core promoter activityQ24531869
Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosisQ24532777
Association of protein phosphatase 2A with polyoma virus medium tumor antigenQ24558730
The interconversion of protein phosphatase 2A between PP2A1 and PP2A0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cellsQ73123232
Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2AQ73176678
Studies on functions of the 63-kDa A- and 74-kDa B'(delta)-regulatory subunits in human erythrocyte protein phosphatase 2A: dissociation and reassociation of the subunitsQ73219073
Characterization of the mitotic phase pRb-directed protein phosphatase activityQ73428248
Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cellsQ73456230
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasmsQ73540311
Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1Q73586077
Protein phosphatase 2A--a 'ménage à trois'Q75292949
Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promotersQ77135076
A question of life or death: the p53 tumor suppressor geneQ77402257
Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2AQ77985300
Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant formsQ78122298
PPX, a novel protein serine/threonine phosphatase localized to centrosomesQ24564714
The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiaeQ24598514
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylationQ24601280
Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigenQ24603984
A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brainQ24607382
WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2AQ24608094
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set geneQ24629998
Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2AQ24630574
p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2AQ24647806
Induction of cyclin D1 by simian virus 40 small tumor antigenQ24648223
Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activityQ24648313
Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypesQ24648347
Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigensQ24649933
Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progressionQ24651574
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated proteinQ24675387
The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130Q24685935
A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxideQ27930290
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeastQ27930579
Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functionsQ27930953
Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiaeQ27931065
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatasesQ27932611
Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiaeQ27933196
Yeast protein serine/threonine phosphatases: multiple roles and diverse regulationQ27933724
Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genesQ27934520
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiaeQ27938427
Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2AQ28117628
Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator geneQ28139952
Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2Q28141657
Regulation of protein phosphatase 2A activity by heat shock transcription factor 2Q28142799
Regulation of beta-catenin signaling in the Wnt pathwayQ28144905
Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatusQ28198531
Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunitsQ28212228
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]Q28212545
Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)Q28610016
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylationQ28638545
Cyclin G is a transcriptional target of the p53 tumor suppressor proteinQ28639991
The structure and regulation of protein phosphatasesQ29618929
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinaseQ30453375
Cell cycle-regulated proteolysis of mitotic target proteinsQ30454298
B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2AQ30454362
Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'.Q30880111
The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigensQ31167810
Regulation of protein phosphatase 2A activity by caspase-3 during apoptosisQ32064384
CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphataseQ33237530
Protein phosphatase 2A from Xenopus oocytes. Characterization during meiotic cell divisionQ33240455
Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2AQ33285655
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoterQ33559371
Regulation of protein kinase cascades by protein phosphatase 2A.Q33632946
Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).Q33649564
Brain protein serine/threonine phosphatasesQ33680938
Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.Q33810466
Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stressQ33890192
Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acidQ33918169
Protein serine/threonine phosphatases; an expanding familyQ33930590
A general screen for mutant of Saccharomyces cerevisiae deficient in tRNA biosynthesisQ33955755
The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.Q33961070
Identification by molecular cloning of two cDNA sequences from the plant Brassica napus which are very similar to mammalian protein phosphatases-1 and -2A.Q33962249
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.Q34181194
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.Q34324670
The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.Q34327099
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.Q34345750
Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A.Q34386589
Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunitQ34437313
Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinasesQ34438124
Inhibition of cdc2 activation by INH/PP2A.Q34441407
Isolation and characterization of par1(+) and par2(+): two Schizosaccharomyces pombe genes encoding B' subunits of protein phosphatase 2A.Q34608934
Molecular cloning and sequence analysis of the catalytic subunit of bovine type 2A protein phosphataseQ34638898
Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.Q39576996
Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cellsQ40021232
Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphataseQ40064412
Simian virus 40 large T-antigen-dependent DNA replication is activated by protein phosphatase 2A in vitro.Q40108931
Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.Q40365505
Tau domains, phosphorylation, and interactions with microtubules.Q40416733
Constant expression and activity of protein phosphatase 2A in synchronized cellsQ40640038
Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesisQ40640926
Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3Q40789153
The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis.Q40807039
Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compoundsQ40856599
Adenovirus E4orf4 protein interacts with both Balpha and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with BalphaQ40860416
Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promotersQ40891345
Role of janus kinase-2 in insulin-mediated phosphorylation and inactivation of protein phosphatase-2A and its impact on upstream insulin signalling componentsQ40913475
An anchoring factor targets protein phosphatase 2A to brain microtubulesQ40914283
A role of cyclin G in the process of apoptosisQ40932309
Protein serine/threonine phosphatases as binding proteins for okadaic acidQ40933317
Association between src-kinases and the polyoma virus oncogene middle T-antigen requires PP2A and a specific sequence motifQ40936714
Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cellsQ40940051
Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activityQ40944433
The end in sight: terminating translation in eukaryotesQ40951525
Disruption of the cytoskeleton in Alzheimer's diseaseQ40958030
Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatasesQ40963717
Rapid dephosphorylation of p107 following UV irradiation.Q40973377
Autoregulation of protein phosphatase type 2A expressionQ41024570
Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A.Q41027163
The decision to enter mitosisQ41030388
The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.Q41079164
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 functionQ41082941
Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activationQ41089273
Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65alphaQ41093737
Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kappaB activationQ41105089
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycinQ41109535
Calyculin A and okadaic acid: inhibitors of protein phosphatase activityQ69337324
Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2AQ69838535
Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heartQ70149199
Purification and properties of polycation-stimulated phosphorylase phosphatases from rabbit skeletal muscleQ70161644
The interrelationship between cAMP-dependent alpha and beta subunit phosphorylation in the regulation of phosphorylase kinase activity. Studies using subunit specific phosphatasesQ70166336
Cardiac contractile protein phosphatases. Purification of two enzyme forms and their characterization with subunit-specific antibodiesQ70175437
Isolation and characterization of rabbit skeletal muscle protein phosphatases C-I and C-IIQ70191707
Negative regulation of mitosis by the fission yeast protein phosphatase ppa2Q70458354
Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferaseQ70473593
Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoterQ70523784
Dephosphorylation of catalytic subunit of cAMP-dependent protein kinase at Thr-197 by a cellular protein phosphatase and by purified protein phosphatase-2AQ70870860
Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretionQ71103305
Autophosphorylation‐activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2AQ71650129
Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidneyQ71672579
The effect of phosphorylation on the antigenic reactivity of p53 in cultured human keratinocytesQ71710752
cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cellsQ71825564
12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimerQ71860013
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transductionQ72068815
Hyperphosphorylation of p53 induced by okadaic acid attenuates its transcriptional activation functionQ72092517
Expression of the catalytic and regulatory subunits of protein phosphatase type 2A may be differentially modulated during retinoic acid-induced granulocytic differentiation of HL-60 cellsQ72149151
Activation of protein kinases and the inactivation of protein phosphatase 2A in tumour necrosis factor and interleukin-1 signal-transduction pathwaysQ72221411
The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramideQ72259895
Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetateQ72332665
Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acidQ72733108
Serine/threonine protein phosphatases in the control of cell functionQ72759153
An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2AQ72767188
Down-regulation by retinoic acid of the catalytic subunit of protein phosphatase type 2A during granulocytic differentiation of HL-60 cellsQ72966536
PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.Q35187434
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval inductionQ35207211
Structure and function of simian virus 40 large tumor antigenQ35231378
Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.Q35614264
Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cellsQ35776511
Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.Q35839940
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirusQ35996377
Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2AQ36178824
Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfishQ36222329
A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycleQ36235418
Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.Q36302019
Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phaseQ36530320
SCS1, a multicopy suppressor of hsp60-ts mutant alleles, does not encode a mitochondrially targeted proteinQ36555351
Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.Q36655478
Specific enzymatic dephosphorylation of the retinoblastoma proteinQ36659274
Molecular cloning and developmental regulation of expression of two isoforms of the catalytic subunit of protein phosphatase 2A from Xenopus laevisQ36671055
Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformationQ36685985
Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transductionQ36718172
Protein phosphatase 2A is required for the initiation of chromosomal DNA replicationQ36753616
Protein phosphatases in higher plants: multiplicity of type 2A phosphatases in Arabidopsis thalianaQ36770716
Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discsQ36770809
High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoformsQ36792704
The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.Q36827839
Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.Q36885712
Cantharidin-binding protein: identification as protein phosphatase 2AQ37342231
Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in DrosophilaQ37370787
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitorsQ37549774
Okadaic acid: a new probe for the study of cellular regulationQ37876246
Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatasesQ38297819
Comparison of heterotrimeric protein phosphatase 2A containing different B subunits.Q38305542
A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity.Q38307021
Molecular basis of competition between HSF2 and catalytic subunit for binding to the PR65/A subunit of PP2A.Q38310959
Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunitQ38326341
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2AQ28609056
Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.Q41147532
In vivo activation of a microtubule-associated protein kinase during meiotic maturation of the Xenopus oocyteQ41201434
Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cellsQ41237231
Deregulation of Translational Control of the 65-kDa Regulatory Subunit (PR65α) of Protein Phosphatase 2A Leads to Multinucleated CellsQ41296445
Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.Q41333262
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.Q41364422
Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activityQ41444018
Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A.Q41479951
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblastsQ41480433
Okadaic acid, a ptotein phosphatase inhibitor, induces sister-chromatid exchanges depending on the presence of bromodeoxyuridineQ41525572
NH2-terminal modification of the phosphatase 2A catalytic subunit allows functional expression in mammalian cellsQ41603760
Ceramide stimulates a cytosolic protein phosphataseQ41635180
Inhibition of mitosis by okadaic acid: possible involvement of a protein phosphatase 2A in the transition from metaphase to anaphaseQ41651100
Reduction of Ha-ras-induced cellular transformation by elevated expression of protein phosphatase type 2A.Q41664829
TOR signalling and control of cell growthQ41678494
Okadaic acid: a reversible inhibitor of neoplastic transformation of mouse fibroblastsQ41752782
Control of protein phosphatase 2A by simian virus 40 small-t antigenQ41814391
Signal transduction of stress via ceramideQ41841345
Three distinct forms of type 2A protein phosphatase in human erythrocyte cytosolQ41872641
Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2AQ41973818
Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis.Q41983294
Protein phosphatase 2A is expressed in response to colony-stimulating factor 1 in macrophages and is required for cell cycle progression independently of extracellular signal-regulated protein kinase activityQ42004024
Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replicationQ42068272
Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatasesQ42161949
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsQ42163759
Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivationQ42439479
Phosphatase 2A and polo kinase, two antagonistic regulators of cdc25 activation and MPF auto-amplification.Q42478790
Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytesQ42479761
The phosphotyrosyl phosphatase activator gene is a novel p53 target geneQ42487356
Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture.Q42500589
Modulation of the substrate specificity of the polycation-stimulated protein phosphatase from Xenopus laevis oocytesQ42501613
Important role for phylogenetically invariant PP2Acalpha active site and C-terminal residues revealed by mutational analysis in Saccharomyces cerevisiaeQ42551691
The PR55 and PR65 Subunits of Protein Phosphatase 2A from Xenopus laevis. Molecular Cloning and Developmental Regulation of ExpressionQ42678836
Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigenQ42797548
v-Src-induced transformation is inhibited by okadaic acidQ42805642
Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinasesQ42809270
Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphataseQ42809576
CK2alpha-protein phosphatase 2A molecular complex: possible interaction with the MAP kinase pathway.Q42817837
Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitroQ42832457
Rox3 and Rts1 function in the global stress response pathway in baker's yeastQ42966400
Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiaeQ43174340
HEAT repeats in the Huntington's disease proteinQ45307276
Polyoma virus transforming protein associates with the product of the c-src cellular geneQ45798405
INH, a negative regulator of MPF, is a form of protein phosphatase 2AQ45946904
Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.Q45988786
Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeastQ46108071
Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.Q46417202
Constitutively active protein phosphatase 1alpha causes Rb-dependent G1 arrest in human cancer cellsQ46808819
Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos.Q47070086
The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase.Q47070184
Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.Q47071679
Purification and characterization of ceramide-activated protein phosphatasesQ47710075
Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B'' (delta) regulatory subunit in vitro and identification of the phosphorylation sitesQ47749702
Regulation of recombinant PKC alpha activity by protein phosphatase 1 and protein phosphatase 2A.Q47800337
A positive role for the PP2A catalytic subunit in Wnt signal transduction.Q47826110
PTPA regulating PP2A as a dual specificity phosphataseQ47844632
Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transitionQ47853582
Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12.Q47906427
Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alphaQ28237230
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structureQ28238073
The ancient regulatory-protein family of WD-repeat proteinsQ28248516
Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemiaQ28250694
HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2AQ28253208
Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2AQ28254771
Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus productionQ28256684
Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectivelyQ28263062
Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunitsQ28265452
Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2AQ28271017
Molecular cloning of a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2AQ28273569
Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genesQ28279310
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility geneQ28281071
Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11Q28284284
Alterations of the PPP2R1B gene in human lung and colon cancerQ28284845
Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23Q28287247
A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptorQ28289876
Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12Q28290240
The role of ceramide in cell signalingQ28290482
Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2AQ28291327
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domainQ28295415
Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 proteinQ28295979
HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpointQ28302213
Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vprQ28302512
Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphataseQ28359919
Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit CalphaQ28506401
Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42Q28506786
Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during developmentQ28507700
A new member of the alpha4-related molecule (alpha4-b) that binds to the protein phosphatase 2A is expressed selectively in the brain and testisQ28511760
Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2AQ28567607
Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neuronsQ28569635
Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulationQ28578280
CyclinG contributes to G2/M arrest of cells in response to DNA damageQ28581413
Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinaseQ28582965
Functional analysis of conserved domains in the phosphotyrosyl phosphatase activator. Molecular cloning of the homologues from Drosophila melanogaster and Saccharomyces cerevisiaeQ48023035
Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brainQ48078489
Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferaseQ48087232
Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathiesQ48125013
Ceramide activates heterotrimeric protein phosphatase 2A.Q48246807
Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycleQ48251043
Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reactionQ48264938
Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.Q48316651
A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.Q48445015
Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilamentsQ48591344
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.Q48654126
A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn.Q49018988
The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterizationQ49076762
Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and XenopusQ49147216
MPF amplification in Xenopus oocyte extracts depends on a two-step activation of cdc25 phosphatase.Q50742256
Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases.Q50877175
Resolution and reassociation of three distinct components from pig heart phosphoprotein phosphataseQ50930144
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.Q52170853
In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons.Q52204170
Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states.Q52207762
The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle.Q52540750
The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis.Q52552641
Okadaic acid inhibits PDGF-induced proliferation and decreases PDGF receptor number in C3H/10T1/2 mouse fibroblasts.Q53499616
Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiencyQ53932148
Tubulin and MAP2 regulate the PCSL phosphatase activity. A possible new role for microtubular proteins.Q54359273
Highly frequent single amino acid substitution in mammalian elongation factor 2 (EF-2) results in expression of resistance to EF-2-ADP-ribosylating toxins.Q54400378
Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells.Q54661109
Functional expression of human and Arabidopsis protein phosphatase 2A in Saccharomyces cerevisiae and isolation of dominant-defective mutantsQ56902204
Specificity of the polycation-stimulated (type-2A) and ATP, Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinaseQ57082915
Synthetic peptides as model substrates for the study of the specificity of the polycation-stimulated protein phosphatasesQ57082916
Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase ActivationQ57711698
Dephosphorylation of phosphoproteins and synthetic phosphopeptides. Study of the specificity of the polycation-stimulated and MgATP-dependent phosphorylase phosphatasesQ58037643
Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2AQ58485375
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinasesQ59097215
Association of the polyomavirus middle-T antigen with c-yes proteinQ59098242
Tautomycin from the bacterium Streptomyces verticillatusQ61770148
Functional domains of template-activating factor-I as a protein phosphatase 2A inhibitorQ64381472
c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells.Q64967336
Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatasesQ68257942
An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinaseQ69001665
Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytesQ69334325
P433issuePt 3
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
P304page(s)417-39
P577publication date2001-02-01
P1433published inBiochemical JournalQ864221
P1476titleProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
P478volume353

Reverse relations

cites work (P2860)
Q40246228(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit
Q8699668411 Reversible methylation of protein phosphatase 2A
Q4054500815-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity
Q532250755'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
Q33976501A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A
Q24626425A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication
Q28471792A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC
Q48104450A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity
Q24306355A beta-arrestin 2 signaling complex mediates lithium action on behavior
Q28480922A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat
Q28542409A comparative study on in vitro osteogenic priming potential of electron spun scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for tissue engineering application
Q40060610A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus
Q54542480A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer.
Q42157204A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
Q37293324A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide
Q24306896A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1
Q28564822A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis
Q37357124A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation
Q40205480A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A.
Q36818153A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors
Q57279385A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
Q44654552A morphological and genetic characterization of metamorphosis in the ascidian Boltenia villosa
Q35083288A mouse model of uterine leiomyosarcoma
Q34962101A network of rice genes associated with stress response and seed development
Q48935261A nonimprinted Prader-Willi Syndrome (PWS)-region gene regulates a different chromosomal domain in trans but the imprinted pws loci do not alter genome-wide mRNA levels
Q39972783A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation
Q33856559A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers
Q42370246A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization
Q43003119A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi.
Q24312822A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A
Q41947183A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1.
Q46124670A serine/threonine-protein phosphatase PP2A catalytic subunit is essential for asexual development and plant infection in Magnaporthe oryzae.
Q33721223A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles
Q58804984A stable association with PME-1 may be dispensable for PP2A demethylation - implications for the detection of PP2A methylation and immunoprecipitation
Q37244205A subset of RAB proteins modulates PP2A phosphatase activity
Q35154724A systems-level interrogation identifies regulators of Drosophila blood cell number and survival
Q42430385A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila
Q28216363A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta
Q37874426AKAP phosphatase complexes in the heart
Q37158353AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
Q37175528AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury
Q34093651ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.
Q41784558ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).
Q30308300ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation
Q34888948Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts
Q33844595Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Q33816854Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism
Q34047058Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits
Q42442461Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes
Q43037981Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.
Q42803176Activation of the coactivator four-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase 2A.
Q30252408Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.
Q42322428Active β-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A.
Q33840532Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: role of protein phosphatase 2A.
Q28579265Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway
Q40340573Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism
Q40642757Adhesion regulation of stromal cell-derived factor-1 activation of ERK in lymphocytes by phosphatases
Q33824868Age-Related Hypercholesterolemia and HMG-CoA Reductase Dysregulation: Sex Does Matter (A Gender Perspective).
Q42818619Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex
Q37901194Alcoholic-induced hepatic steatosis--role of ceramide and protein phosphatase 2A.
Q28593756Alpha4 is an essential regulator of PP2A phosphatase activity
Q40607687Altering the holoenzyme composition and substrate specificity of protein phosphatase 2A.
Q42582794Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation
Q24310712An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
Q37485704An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.
Q36621450An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A).
Q41775985An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator
Q24318802An integrated workflow for charting the human interaction proteome: insights into the PP2A system
Q88800695Analysis of Potential Alterations Affecting SETBP1 as a Novel Contributing Mechanism to Inhibit PP2A in Colorectal Cancer Patients
Q34298869Anp32e (Cpd1) and related protein phosphatase 2 inhibitors
Q35989348Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila
Q34386920Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast
Q28583419Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart
Q52368982Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.
Q36837717Applying a targeted label-free approach using LC-MS AMT tags to evaluate changes in protein phosphorylation following phosphatase inhibition
Q85676705Arabidopsis PHOSPHOTYROSYL PHOSPHATASE ACTIVATOR is essential for PROTEIN PHOSPHATASE 2A holoenzyme assembly and plays important roles in hormone signaling, salt stress response, and plant development
Q60915991Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling
Q28538642Arsenic sulfide promotes apoptosis in retinoid acid resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein
Q37412348Assembly and structure of protein phosphatase 2A.
Q35184749Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups
Q33700607Association of Tat with Promoters of PTEN and PP2A Subunits Is Key to Transcriptional Activation of Apoptotic Pathways in HIV-Infected CD4+ T Cells
Q39051864Atypical Protein Phosphatase 2A Gene Families Do Not Expand via Paleopolyploidization
Q41434813Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts.
Q37605239Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Q36443322B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase
Q24307014B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer
Q39674654B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster
Q24303557B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK
Q34132451B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice
Q36216530B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.
Q37495356BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells.
Q36809889Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation
Q64134258Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of
Q47922301Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis
Q34411340Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
Q30574568Bioengineered protein phosphatase 2A: update on need
Q51969062Bistable MAP kinase activity: a plausible mechanism contributing to maintenance of late long-term potentiation.
Q36500479Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy
Q36515596Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell.
Q37033370Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
Q42824829C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton.
Q52659500C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling.
Q90316655CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease
Q83821124CIP2A expression is associated with synovial hyperplasia and invasive function of fibroblast-like synoviocytes in rheumatoid arthritis
Q86254478CIP2A facilitates apoptotic resistance of fibroblast-like synoviocytes in rheumatoid arthritis independent of c-Myc expression
Q24319683CIP2A inhibits PP2A in human malignancies
Q54393527CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation.
Q39664633CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
Q42176198Ca2+/calmodulin‐stimulated PDE1 regulates the beta‐catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells
Q39912728Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.
Q58129865Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
Q36805842Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells
Q38692782Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway
Q34634141Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.
Q36879581Cardiomyocyte specific deletion of PP2A causes cardiac hypertrophy
Q37027333Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development.
Q54658297Catechin stimulates osteogenesis by enhancing PP2A activity in human mesenchymal stem cells
Q34986770Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.
Q36498234Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.
Q26851771Cell Biology Symposium: feed efficiency: mitochondrial function to global gene expression
Q92636595Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins
Q37628726Cell signalling and radiation survival: the impact of protein phosphatases
Q34468798Cell transformation by the middle T-antigen of polyoma virus
Q42489899Cell type-dependent control of NF-Y activity by TGF-beta
Q37086705Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.
Q39259973Cellular Casein Kinase 2 and Protein Phosphatase 2A Modulate Replication Site Assembly of Bluetongue Virus.
Q26863333Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor
Q41846357Cellular serine/threonine phosphatase activity during human cytomegalovirus infection
Q39643015Ceramide Produces Apoptosis Through Induction of p27kip1by Protein Phosphatase 2A-dependent Akt Dephosphorylation in PC-3 Prostate Cancer Cells
Q28087030Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
Q48494123Cerebral postischemic reperfusion-induced demethylation of the protein phosphatase 2A catalytic subunit
Q27347311Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility
Q31116561Chaperonin assisted overexpression, purification, and characterisation of human PP2A methyltransferase.
Q42012989Characterization and activity determination of the human protein phosphatase 2A catalytic subunit α expressed in insect larvae.
Q57183794Characterization of Maf1 in Arabidopsis: function under stress conditions and regulation by the TOR signaling pathway
Q46833949Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2.
Q24293459Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.
Q51745888Characterization of potato (Solanum tuberosum) and tomato (Solanum lycopersicum) protein phosphatases type 2A catalytic subunits and their involvement in stress responses.
Q24535025Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution
Q24318664Characterizing the new transcription regulator protein p60TRP
Q26767090Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus
Q42556634Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation
Q34960781Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity
Q36172723Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner
Q31158092Cloning and characterization of TaPP2AbB"-α, a member of the PP2A regulatory subunit in wheat
Q82079732Cocaine- and amphetamine-regulated transcript accelerates termination of follicle-stimulating hormone-induced extracellularly regulated kinase 1/2 and Akt activation by regulating the expression and degradation of specific mitogen-activated protein
Q38828243Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway.
Q74147400Combinatorial control of protein phosphatase-1
Q37708933Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
Q38632111Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function
Q41863578Competing docking interactions can bring about bistability in the MAPK cascade
Q34635963Complex energy landscape of a giant repeat protein
Q37588345Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia.
Q34613172Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2
Q58607655Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model
Q26776182Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases
Q28255422Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau
Q34675896Cross signaling, cell specificity, and physiology
Q37229497Cross-linking and mass spectrometry methodologies to facilitate structural biology: finding a path through the maze
Q34121462Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen
Q41771446Crosstalk and signaling switches in mitogen-activated protein kinase cascades
Q34000718Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
Q35883582Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells.
Q36149522Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats
Q33801128Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs
Q27310439Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila
Q28638418Cyclin G recruits PP2A to dephosphorylate Mdm2
Q28214848Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest
Q24675495Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest
Q24302542Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.
Q33861397Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.
Q28200942Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A
Q24310454Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1
Q92527353DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
Q49787455DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury
Q28543162DMH1 increases glucose metabolism through activating Akt in L6 rat skeletal muscle cells
Q40456885Deactivation of sphingosine kinase 1 by protein phosphatase 2A.
Q38162438Dealing with hunger: Metabolic stress responses in tumors
Q27690875Defect of insulin signal in peripheral tissues: Important role of ceramide
Q28741172Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma
Q44376511Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1.
Q74372626DeltaNp63 induces beta-catenin nuclear accumulation and signaling
Q24316356Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation
Q40000679Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen
Q28215036Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides
Q46973958Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells
Q36560608Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice
Q35095669Determinants for Substrate Specificity of Protein Phosphatase 2A.
Q50128117Developmental and light regulation of tumor suppressor protein PP2A in the retina.
Q37627373Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice.
Q48378487Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.
Q28577688Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression
Q46950668Differential involvement of reactive oxygen species in apoptosis caused by the inhibition of protein phosphatase 2A in Jurkat and CCRF-CEM human T-leukemia cells
Q64120213Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma
Q50336648Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation
Q35129344Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
Q47197473Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A.
Q38521701Disruption of a guard cell-expressed protein phosphatase 2A regulatory subunit, RCN1, confers abscisic acid insensitivity in Arabidopsis.
Q24318755Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
Q36321491Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity
Q28588371Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A
Q43293580Diversity in subcellular targeting of the PP2A B'eta subfamily members
Q48429500Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.
Q41013173DockStar: a novel ILP-based integrative method for structural modeling of multimolecular protein complexes
Q36480352Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function
Q44225509Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis
Q44508750Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases
Q33770397Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons
Q33964840Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation
Q42369326Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration.
Q37437224ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis
Q34288822EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Q26785565Effect of alcohol on adipose tissue: a review on ethanol mediated adipose tissue injury
Q51836563Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells.
Q35597474Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells
Q43014382Effectiveness of intranasal vaccination against Angiostrongylus costaricensis using a serine/threonine phosphatase 2 A synthetic peptide and recombinant antigens.
Q38152420Embryonic and larval neural connectivity: progressive changes in synapse form and function at the neuromuscular junction mediated by cytoskeletal regulation
Q36460968Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection
Q36743535Emerging roles of nuclear protein phosphatases
Q58581550Emodin rescued hyperhomocysteinemia-induced dementia and Alzheimer's disease-like features in rats
Q92891409Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A
Q30432914Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.
Q35212828Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43.
Q35121879Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A.
Q42108356Enhancing Therapeutic Efficacy of Cisplatin by Blocking DNA Damage Repair
Q34117528Enumeration of the simian virus 40 early region elements necessary for human cell transformation
Q39354035EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target
Q37284401Epigenetic mechanisms in lupus
Q35807430Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species
Q34007879Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A.
Q34104555Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers
Q34305548Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster
Q49195214Estradiol suppresses phosphorylation of ERα serine 167 through upregulation of PP2A in breast cancer cells
Q36610469Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.
Q41842719Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy
Q24297954Expression of AIE-75 PDZ-domain protein induces G2/M cell cycle arrest in human colorectal adenocarcinoma SW480 cells
Q37086451Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes
Q55423815Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.
Q37665510FAM122A, a new endogenous inhibitor of protein phosphatase 2A
Q42806438FR177391, a new anti-hyperlipidemic agent from Serratia. IV. Target identification and validation by chemical genetic approaches
Q39126141FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors
Q35945171FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
Q34562794Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury
Q51655702Fine mapping and candidate gene analysis of spd6, responsible for small panicle and dwarfness in wild rice (Oryza rufipogon Griff.).
Q44421649Fluorescent Peptide Probes for High-Throughput Measurement of Protein Phosphatases
Q35134895Focal Cerebral Ischemia Reduces Protein Phosphatase 2A Subunit B Expression in Brain Tissue and HT22 Cells
Q38625831Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase
Q41542170Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase
Q61054160Functional expression cloning reveals proapoptotic role for protein phosphatase 4
Q35035132Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese
Q33555022Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes
Q36561763Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5.
Q35070054Fusion of the tumor-suppressor gene CHEK2 and the gene for the regulatory subunit B of protein phosphatase 2 PPP2R2A in childhood teratoma
Q38018652G-protein coupled receptor resensitization-appreciating the balancing act of receptor function.
Q24646920G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia
Q45138638Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
Q40120458Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha
Q41831225Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities.
Q36058960Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption.
Q21245114Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactions
Q42086826Gene flow at major transitional areas in sea bass (Dicentrarchus labrax) and the possible emergence of a hybrid swarm
Q51850859Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.
Q34458003Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein
Q40042252Genetic variants in PPP2CA are associated with gastric cancer risk in a Chinese population
Q49832688Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway
Q43798465Genomic structure of the mouse PP4 gene: a developmentally regulated protein phosphatase
Q42143904Germline-specific labeling of the somatic chromosomes by protein phosphatase 2A and histone H3S28 phosphorylation in Acricotopus lucidus
Q33230781Gi protein-mediated translocation of serine/threonine phosphatase to the plasma membrane and apoptosis of ovarian cancer cell in response to gonadotropin-releasing hormone antagonist cetrorelix
Q37597393Global analysis of serine/threonine and tyrosine protein phosphatase catalytic subunit genes in Neurospora crassa reveals interplay between phosphatases and the p38 mitogen-activated protein kinase
Q88595330Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis
Q33949745Glucose and cAMP: adversaries in the regulation of hepatic gene expression
Q40663050Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells
Q42184009Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast
Q40629489Glutaredoxin Exerts an Antiapoptotic Effect by Regulating the Redox State of Akt
Q33403988Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases
Q91964293Greatwall-Endosulfine: A Molecular Switch that Regulates PP2A/B55 Protein Phosphatase Activity in Dividing and Quiescent Cells
Q36739639Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liver
Q33664446HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.
Q38794917Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes
Q37897736Heat shock protein 40 (Hsp40) plays a key role in the virus life cycle
Q34070470Heavy metal-induced metallothionein expression is regulated by specific protein phosphatase 2A complexes
Q40599506Hepatitis B virus X protein impairs α-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A.
Q42830844Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair
Q37155577Hepatotoxic seafood poisoning (HSP) due to microcystins: a threat from the ocean?
Q33223554Heterogeneous nuclear ribonucleoprotein A2 is a SET-binding protein and a PP2A inhibitor.
Q28584125High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit
Q34336234Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis
Q40691796Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.
Q35192607Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice
Q37982050Human gene control by vital oncogenes: revisiting a theoretical model and its implications for targeted cancer therapy
Q73466868Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
Q41538550Hyperglycemia reduces PP2A subunit B expression in a middle cerebral artery occlusion animal model
Q38170011Hyperphosphorylated tau is implicated in acquired epilepsy and neuropsychiatric comorbidities
Q33886330Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions
Q48290270Hypothermic regulation of astrocyte proteome profile in experimental stroke
Q39768636Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
Q35140072IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation
Q28115805IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis
Q41829648IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling
Q41225103Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aα catalytic subunit
Q33930288Identification and characterization of genes required for cell-to-cell fusion in Neurospora crassa
Q31059965Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene
Q34699427Identification of MV-generated ROS responsive EST clones in floral buds of Litchi chinensis Sonn
Q33822354Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
Q24300875Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway
Q33894754Identification of a novel TGFβ/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer
Q33311406Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevis development
Q28222344Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
Q92645893Identification of genes associated with SiHa cell sensitivity to paclitaxel by CRISPR-Cas9 knockout screening
Q41859770Identification of lung-cancer-related genes with the shortest path approach in a protein-protein interaction network.
Q39062088Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication
Q50306213Identification of two inherited copy number variants in a male with autism supports two-hit and compound heterozygosity models of autism
Q35849989Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice
Q36959063Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway.
Q33643323Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction
Q44695560Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts
Q33893880In silico investigation of potential TRAF6 inhibitor from traditional Chinese medicine against cancers
Q33876312In silico investigation of potential mTOR inhibitors from traditional Chinese medicine for treatment of Leigh syndrome
Q33895166In silico investigation of potential pyruvate kinase M2 regulators from traditional Chinese medicine against cancers
Q36536668Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins
Q45863659Inactivation of protein-phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits
Q53214524Inactivation of the AMP-activated protein kinase by glucose in cardiac myocytes: a role for the pentose phosphate pathway.
Q35134056Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus
Q37091930Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac
Q27478029Inhibition of Alpha Interferon Signaling by Hepatitis B Virus
Q52727111Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells.
Q33706983Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.
Q34070349Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells
Q34777845Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair
Q40150675Inhibition of serine-threonine protein phosphatases in monocyte chemoattractant protein-1 expression in Helicobacter pylori-stimulated gastric epithelial cells
Q36352070Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase
Q28578006Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels
Q44353873Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells
Q46852229Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Q24292286Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
Q78758328Integrin alpha2beta1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway
Q33947256Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.
Q33329230Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes
Q24293158Interaction of nucleoredoxin with protein phosphatase 2A
Q36857087Interactions of HIV-1 viral protein R with host cell proteins
Q54478839Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.
Q36399968Intestinal epithelial cell signalling and host-derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria.
Q37469672Intranasal immunization of lambs with serine/threonine phosphatase 2A against gastrointestinal nematodes.
Q36158803Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models
Q37652730Involvement of SET in the Wnt signaling pathway and the development of human colorectal cancer
Q42796003Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression
Q34326195Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21.
Q91370954KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway
Q47226338Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition.
Q36544034Kinase and phosphatase: the cog and spring of the circadian clock
Q37994633Kinases, phosphatases and proteases during sperm capacitation.
Q38337002Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cells
Q39232395LEM-4 promotes rapid dephosphorylation of BAF during mitotic exit
Q34500924Lead dysregulates serine/threonine protein phosphatases in human neurons.
Q37330814Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer
Q35000523Lessons in signaling and tumorigenesis from polyomavirus middle T antigen
Q39505755Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes
Q24338461Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells
Q30443046Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions
Q35134617Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis
Q27934658Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle
Q24318937Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
Q55285624Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines.
Q35856923MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis
Q35245786MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac
Q91812801Mechanisms of Disease Progression and Resistance to Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia: An Update
Q37433774Mechanisms of HCV survival in the host
Q28081729Mechanisms of cancer cell killing by the adenovirus E4orf4 protein
Q27327234Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation
Q39500731Melatonin attenuates decrease of protein phosphatase 2A subunit B in ischemic brain injury
Q39083904Merkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signaling
Q95487894Metabolic responses of the growing Daphnia similis to chronic AgNPs exposure as revealed by GC-Q-TOF/MS and LC-Q-TOF/MS
Q99596103Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models
Q84572564Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats
Q41959555Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity
Q47259369Methylation-regulated decommissioning of multimeric PP2A complexes.
Q90409957MicroRNA Profile Identifies miR-6165 Could Suppress Gastric Cancer Migration and Invasion by Targeting STRN4
Q52714356MicroRNA-652 induces NED in LNCaP and EMT in PC3 prostate cancer cells.
Q35059243Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells
Q39361021Microcystin-LR induces ceramide to regulate PP2A and destabilize cytoskeleton in HEK293 cells.
Q39189431Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line
Q42915545Microcystin-LR modulates selected immune parameters and induces necrosis/apoptosis of carp leucocytes.
Q37685585Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii
Q54198228Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells.
Q37893922Modulation of plant HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism
Q36892504Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications
Q60689081Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases
Q34485379Molecular Cloning of the Genes Encoding the PR55/Bβ/δ Regulatory Subunits for PP-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus
Q28505912Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes
Q55358905Molecular chaperoning helps safeguarding mitochondrial integrity and motor functions in the Sahara silver ant Cataglyphis bombycina.
Q44030518Molecular characterization and evolution of the protein phosphatase 2A B' regulatory subunit family in plants
Q35601459Molecular dynamics simulation reveals insights into the mechanism of unfolding by the A130T/V mutations within the MID1 zinc-binding Bbox1 domain
Q34100361Molecular expression and characterization of a novel protein phosphatase 2A gene from Clonorchis sinensis
Q33952539Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.
Q36526222Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart
Q39387545Molecular regulation and pharmacological targeting of the β-catenin destruction complex
Q38164164Molecular signatures of chronic myeloid leukemia stem cells
Q30520621Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation
Q35859963Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways
Q44796282Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A.
Q38987696Multiple variants in 5q31.1 are associated with systemic lupus erythematosus susceptibility and subphenotypes in the Han Chinese population.
Q53565865Mutation spectrum in the Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps.
Q33870697N-glycosylation status of E-cadherin controls cytoskeletal dynamics through the organization of distinct β-catenin- and γ-catenin-containing AJs.
Q92868057NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatoce
Q33727744NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase
Q58791683NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation
Q39738661Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage
Q40171692Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.
Q45353511Neural retina leucine‐zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development
Q54591210Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.
Q24630237Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease
Q46669273Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity
Q35893691Nicotine increases dopamine transporter function in rat striatum through a trafficking-independent mechanism
Q36050039Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
Q30459756Noise induced changes in the expression of p38/MAPK signaling proteins in the sensory epithelium of the inner ear.
Q29620040Non-Smad pathways in TGF-beta signaling
Q47846769Noncanonical regulation of insulin-mediated ERK activation by phosphoinositide 3-kinase γ.
Q34226281Norcantharidin analogues: a patent review (2006 - 2010).
Q39913573Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition
Q36420214Norcantharidin inhibits renal interstitial fibrosis by downregulating PP2Ac expression
Q47947167Normal human melanocytes exposed to chronic insulin and glucose supplementation undergo oncogenic changes and methyl group metabolism cellular redistribution
Q37055453Novel molecular targets in the treatment of systemic lupus erythematosus
Q24598698Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit
Q36442523Okadaic acid induces Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by rapamycin
Q52610446Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types.
Q46704865Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia
Q75312804Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice
Q36944247Overexpression of AtPTPA in Arabidopsis increases protein phosphatase 2A activity by promoting holoenzyme formation and ABA negatively affects holoenzyme formation
Q35862574Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins.
Q39347056Overexpression of PP2A-C5 that encodes the catalytic subunit 5 of protein phosphatase 2A in Arabidopsis confers better root and shoot development under salt conditions.
Q35944719Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia
Q40743401Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells
Q35063417Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway
Q41814318Overexpression of the PP2A-C5 gene confers increased salt tolerance in Arabidopsis thaliana
Q44973159Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function
Q33610645Overexpression of the protein phosphatase 2A regulatory subunit a gene ZmPP2AA1 improves low phosphate tolerance by remodeling the root system architecture of maize
Q30433957Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits
Q45218831Oxidative activation of protein kinase Cgamma through the C1 domain. Effects on gap junctions
Q36954084Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies
Q44151230P38 mitogen-activated protein kinase dephosphorylation is regulated by protein phosphatase 2A in human platelets activated by collagen
Q44824844PINning down the c-Myc oncoprotein
Q26991427PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation
Q48208714PP2A (PR65) in Silver Carp: cDNA Cloning and Expression Analysis
Q41122695PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response
Q90748932PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production
Q92591100PP2A Phosphatases Take a Giant Leap in the Post-Genomics Era
Q33503992PP2A and GSK-3beta act antagonistically to regulate active zone development
Q38746849PP2A as a master regulator of the cell cycle
Q36141310PP2A as a mercenary for warring kinases in the egg.
Q38788774PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration.
Q48128686PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential
Q35681295PP2A fulfills its promises as tumor suppressor: which subunits are important?
Q33767159PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation
Q39653330PP2A interaction with Rb2/p130 mediates translocation of Rb2/p130 into the nucleus in all‐Trans retinoic acid‐treated ovarian carcinoma cells
Q24312909PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
Q37186184PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice
Q24337674PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum
Q24301735PP2A regulates HDAC4 nuclear import
Q30544640PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Q36906235PP2A(Cdc55) regulates G1 cyclin stability
Q36563283PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root
Q41627029PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis.
Q33245065PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder
Q38168831PP2A-Mediated Anticancer Therapy
Q36954633PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen
Q33288788PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF
Q33985022PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length
Q27337616PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos
Q92864431PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer
Q27690852PP2A: The Achilles Heal in MDS with 5q Deletion
Q28088747PP2A: The Wolf in Sheep's Clothing?
Q50643244PP2A:B56epsilon is required for eye induction and eye field separation.
Q34251140PP2A:B56ϵ, a Substrate of Caspase-3, Regulates p53-dependent and p53-independent Apoptosis during Development
Q36437685PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer
Q37550617PP2ARts1 is a master regulator of pathways that control cell size
Q24324592PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4
Q37499214PR65A phosphorylation regulates PP2A complex signaling
Q59275554PROTEIN PHOSHATASE 2A B' and Maintain Centromeric Sister Chromatid Cohesion during Meiosis in Arabidopsis
Q22001514PTH inactivates the AKT survival pathway in the colonic cell line Caco-2
Q40421493Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism
Q36499329Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes
Q24321385Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein
Q58095951Parathyroid hormone (1-34) and its analogs differentially modulate osteoblastic RANKL expression via PKA/PP1/PP2A and SIK2/SIK3-CRTC3 signaling
Q42250004Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway
Q33830549Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a
Q35133777Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.
Q90720156Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent
Q48131939Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats.
Q37019493Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction
Q40428553Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells
Q40553265Phosphatase 2A is involved in endothelial cell microtubule remodeling and barrier regulation
Q47313655Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit.
Q56798186Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1
Q45021756Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK.
Q34330600Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.
Q64245408Phosphatases in Mitosis: Roles and Regulation
Q35120898Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question
Q35542014Phosphatases in cell-matrix adhesion and migration
Q37900486Phosphatases: providing safe passage through mitotic exit
Q37667933Phosphoinositide 3-kinase γ inhibits cardiac GSK-3 independently of Akt.
Q42913232Phosphoprotein Phosphatase PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling
Q34289975Phosphoprotein abundance changes in hypertensive cardiac remodeling
Q24627125Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease
Q24306750Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase
Q37296372Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
Q34051988Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer.
Q34323699Phosphorylation of plasma membrane aquaporin regulates temperature-dependent opening of tulip petals.
Q39848755Phosphorylation status of nuclear ribosomal protein S3 is reciprocally regulated by protein kinase C{delta} and protein phosphatase 2A.
Q35372183Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
Q27310118Polyoma small T antigen triggers cell death via mitotic catastrophe
Q42638278Polyomavirus small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression
Q24318289Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
Q40359711Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
Q40586727Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Q33608964Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer
Q33790946Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers
Q86215095Potential role for inhibition of protein phosphatase 2A tumor suppressor in salivary gland malignancies
Q54491379Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.
Q38471496Progesterone as a regulator of phosphorylation in the central nervous system.
Q35143592Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus
Q33686351Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression
Q47252033Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease
Q90288934Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease
Q39146231Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders
Q30445781Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity
Q36215961Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity
Q28551570Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation
Q28070407Protein Phosphatases Involved in Regulating Mitosis: Facts and Hypotheses
Q37595524Protein carboxyl methylation and the biochemistry of memory
Q51602552Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR.
Q35669844Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit
Q34545781Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1
Q34064390Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A
Q53575629Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.
Q24604987Protein kinases and phosphatases in the control of cell fate
Q24540046Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock
Q40260965Protein phosphatase 1 regulates the stability of the circadian protein PER2.
Q28588122Protein phosphatase 1alpha is required for murine lung growth and morphogenesis
Q38674773Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.
Q28214491Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling
Q34592537Protein phosphatase 2A (PP2A) regulatory subunits ParA and PabA orchestrate septation and conidiation and are essential for PP2A activity in Aspergillus nidulans
Q42829975Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor
Q38746890Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells
Q35661433Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster
Q42579120Protein phosphatase 2A activity is required for functional adherent junctions in endothelial cells
Q38888204Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium
Q28345088Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus
Q34519707Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint
Q35571493Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb
Q34838835Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.
Q39137632Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1.
Q24318719Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis
Q37168446Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling
Q36908131Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
Q28212399Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits
Q38302317Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation
Q64268390Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila
Q38953688Protein phosphatase 2A is essential to maintain active Wnt signaling and its Aβ tumor suppressor subunit is not expressed in colon cancer cells
Q37428610Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.
Q24643937Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit
Q37272228Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein
Q34130984Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
Q43984158Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease
Q92457809Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice
Q39647592Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling
Q34585545Protein phosphatase 2A on track for nutrient-induced signalling in yeast
Q41983276Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation.
Q40167725Protein phosphatase 2A plays an important role in migration of bone marrow stroma cells
Q28609103Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
Q33721192Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
Q46580641Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells
Q33184133Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex
Q34590509Protein phosphatase 2A regulates central sensitization in the spinal cord of rats following intradermal injection of capsaicin
Q40407389Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability.
Q35839542Protein phosphatase 2A regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung
Q40684450Protein phosphatase 2A regulates the stability of Pim protein kinases
Q43240765Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation
Q42601859Protein phosphatase 2A regulatory subunits affecting plant innate immunity, energy metabolism, and flowering time--joint functions among B'η subfamily members
Q86242688Protein phosphatase 2A regulatory subunits perform distinct functional roles in the maize pathogen Fusarium verticillioides
Q36421423Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation
Q33596201Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk
Q33496409Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress
Q34045261Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.
Q28187838Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs
Q36137554Protein phosphatase 4--from obscurity to vital functions
Q24310895Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway
Q24293343Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon
Q90431783Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in Drosophila
Q80497745Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation
Q37676786Protein phosphatase-2A is down-regulated in patients within clear cell renal cell carcinoma
Q38210375Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues
Q24632495Protein phosphatases and Alzheimer's disease
Q38200472Protein phosphatases in pancreatic islets.
Q93183779Protein phosphatases in the regulation of mitosis
Q92266130Protein phosphatases regulate growth, development, cellulases and secondary metabolism in Trichoderma reesei
Q43112547Protein phosphatases type 2A mediate tuberization signaling in Solanum tuberosum L. leaves.
Q36646389Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions
Q53062146Proteome-wide search for PP2A substrates in fission yeast.
Q35754722Proteomic Analysis of Fetal Ovary Reveals That Ovarian Developmental Potential Is Greater in Meishan Pigs than in Yorkshire Pigs
Q50464763Proteomic analysis of somatic embryogenesis in Vitis vinifera.
Q82624691Proteomic identification of proteins differentially expressed by nicotinamide in focal cerebral ischemic injury
Q92532343Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability
Q47287112Purification of Target Proteins from Native Tissues: CCT Complex from Bovine Testes and PP2Ac from Porcine Brains
Q38377369Quantitative cardiac phosphoproteomics profiling during ischemia-reperfusion in an immature swine model
Q39886751Quantitative interaction proteomics using mass spectrometry
Q28468277Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells
Q38794957Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells
Q92051442Quercetin alleviates the injury-induced decrease of protein phosphatase 2A subunit B in cerebral ischemic animal model and glutamate-exposed HT22 cells
Q33789455RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection
Q36917696Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.
Q39446920Rapamycin inhibiting Jurkat T cells viability through changing mRNA expression of serine/threonine protein phosphatase 2A.
Q40789497Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells
Q36356365Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium.
Q28609104Ras signaling: PP2A puts Ksr and Raf in the right place
Q41737514Rate enhancement of an interfacial biochemical reaction through localization of substrate and enzyme by an adaptor domain
Q28260445Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid
Q36585748ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia
Q37167292Recent progress on the structure of Ser/Thr protein phosphatases
Q102369375Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma
Q38700387Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition
Q38614375Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
Q46182695Recruitment of protein phosphatase 2A to dorsal ruffles by platelet-derived growth factor in smooth muscle cells: dephosphorylation of Hsp27.
Q34571406Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease
Q40965731Redox regulation of 14-3-3ζ controls monocyte migration
Q38940651Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae
Q41930376Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging
Q42563373Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
Q42724277Regulating the regulators. Conference on protein phosphorylation and protein phosphatases
Q30352756Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3).
Q35250146Regulation of HMG-CoA reductase in mammals and yeast
Q36491745Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1
Q27026038Regulation of PP2A by Sphingolipid Metabolism and Signaling
Q41845625Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes.
Q47393112Regulation of Signal Transduction by DJ-1.
Q37259560Regulation of cardiac excitation and contraction by p21 activated kinase-1
Q47756782Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system
Q27307800Regulation of fission yeast morphogenesis by PP2A activator pta2
Q44020909Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation
Q53630806Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.
Q43829231Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis
Q30446670Regulation of sprouty stability by Mnk1-dependent phosphorylation
Q37311413Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
Q36908208Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family
Q54389317Regulation of α-endosulfine, an inhibitor of protein phosphatase 2A, by multisite phosphorylation.
Q28087413Regulatory roles of phosphorylation in model and pathogenic fungi
Q27324165Resolving tumor heterogeneity: genes involved in chordoma cell development identified by low-template analysis of morphologically distinct cells
Q38838867Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model
Q92399660Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
Q42701264Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5.
Q37557423Role for PP2A in ARF signaling to p53.
Q38648429Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work?
Q42053742Role of B regulatory subunits of protein phosphatase type 2A in myosin II assembly control in Dictyostelium discoideum
Q42026440Role of Ca2+/calmodulin-dependent protein kinase II in Drosophila photoreceptors
Q37729929Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function
Q52605229Role of cantharidin in the activation of IKKα/IκBα/NF‑κB pathway by inhibiting PP2A activity in cholangiocarcinoma cell lines.
Q42816608Role of mTOR in the degradation of IRS-1: regulation of PP2A activity
Q91161226Role of protein phosphatase 2A in PTTH-stimulated prothoracic glands of the silkworm, Bombyx mori
Q42473195Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons
Q92932427Role of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DNA damage response
Q38941676Role of protein phosphatases in genitourinary cancers
Q27693957Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility
Q34305706Role of serine/threonine protein phosphatase 2A in cancer
Q39004833Roles and regulation of protein phosphatase 2A (PP2A) in the heart
Q40452655Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90.
Q37352102Roles of phosphotase 2A in nociceptive signal processing
Q34297126Roles of serine/threonine phosphatases in hippocampal synaptic plasticity.
Q37799093Ryanodine receptor assembly: A novel systems biology approach to 3D mapping
Q40300400S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro
Q34785481S-Adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancer
Q28573293SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process
Q37402482SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways.
Q34463782SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.
Q64890686STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.
Q37705440STRIPAK components determine mode of cancer cell migration and metastasis.
Q46431192Salicylic acid-inducible Arabidopsis CK2-like activity phosphorylates TGA2.
Q35837020Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis
Q33764253Selecting the best frontline treatment in chronic myeloid leukemia
Q36481737Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15
Q39038164Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene
Q40667916Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.
Q58542286Serine-threonine protein phosphatases: Lost in translation
Q37653917Serine/threonine protein phosphatases type 2A and their roles in stress signaling
Q37528958Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome
Q24307927Shugoshin collaborates with protein phosphatase 2A to protect cohesin
Q64242795Signaling Overview of Plant Somatic Embryogenesis
Q26825677Signaling regulation of fetoplacental angiogenesis
Q37856367Signalling by amino acid nutrients
Q36012977Signalling by protein phosphatases and drug development: a systems-centred view.
Q38953772Silencing of STRN4 suppresses the malignant characteristics of cancer cells
Q41680966Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway
Q30435809Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor
Q24297903Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells
Q34714730Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation
Q34068459Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models
Q41223194Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury
Q48003442Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Q44102410Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons.
Q53530037Spatial control of protein phosphatase 2A (de)methylation.
Q40663995Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.
Q42171363Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.
Q34700019Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapy
Q33345022Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots
Q54465674Sphingolipid content in the human uterus and pair-matched uterine leiomyomas remains constant.
Q44933694Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A.
Q42120323Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis
Q30359226Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.
Q27646534Structural Basis of PP2A Inhibition by Small t Antigen
Q24307191Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
Q50977728Structural and functional observations of the P151L MID1 mutation reveal alpha4 plays a significant role in X-linked Opitz Syndrome.
Q27650321Structural bases for recognition of Anp32/LANP proteins
Q27680173Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone
Q27677410Structural basis of protein phosphatase 2A stable latency
Q24648497Structure and function of the PP2A-shugoshin interaction
Q24300049Structure and mechanism of the phosphotyrosyl phosphatase activator
Q27652517Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation
Q24307934Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
Q27642733Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity
Q27678559Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation
Q24337251Structure of the protein phosphatase 2A holoenzyme
Q39619521Structure, evolution and expression of a second subfamily of protein phosphatase 2A catalytic subunit genes in the rice plant (Oryza sativa L.).
Q21263143Structure-Function analysis of the CTLA-4 interaction with PP2A
Q39660456Studying the Regulation of MAP Kinase by MAP Kinase Phosphatases In Vitro and in Cell Systems
Q34974064Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia
Q40900582Sugar signaling of fructan metabolism: New insights on protein phosphatases in sucrose-fed wheat leaves.
Q28551662Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach
Q37356277Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells
Q36533561Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B″ subunit targeting of PP2A to centrosomes in C. elegans
Q37322293Supramolecular assemblies and localized regulation of voltage-gated ion channels.
Q37017778Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
Q36406308Systematic study of cis-antisense miRNAs in animal species reveals miR-3661 to target PPP2CA in human cells
Q36969905Systemic lupus erythematosus: new molecular targets
Q38366569Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics.
Q44246783TAP46 plays a positive role in the ABSCISIC ACID INSENSITIVE5-regulated gene expression in Arabidopsis.
Q48111731TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Q39155096TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes
Q35000235Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A-dependent phospho-Akt inactivation in estrogen receptor-negative human breast cancer cells
Q30886700Target gene approaches: Gene expression in Daphnia magna exposed to predator-borne kairomones or to microcystin-producing and microcystin-free Microcystis aeruginosa
Q57169683Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late
Q33348585Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice
Q37800284Targeting cytoskeleton reorganisation as antimetastatic treatment.
Q24658001Targeting protein serine/threonine phosphatases for drug development
Q42243989Tau kinases and phosphatases
Q49884014Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe
Q39034077Tetra-arsenic tetra-sulfide (As4S 4) promotes apoptosis in retinoid acid -resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein
Q37119753The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation
Q64257020The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neurons
Q46988520The Arabidopsis rcn1-1 mutation impairs dephosphorylation of Phot2, resulting in enhanced blue light responses
Q47072136The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction.
Q35834456The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
Q33967311The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition
Q36782507The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.
Q39836205The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex
Q28088697The Basic Biology of PP2A in Hematologic Cells and Malignancies
Q44072892The B″ regulatory subunit of protein phosphatase 2A mediates the dephosphorylation of rice retinoblastoma-related protein-1.
Q28748241The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly
Q89835318The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets
Q47109520The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1.
Q30426855The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation
Q42231430The G2 checkpoint-a node-based molecular switch
Q37999289The Greatwall kinase: a new pathway in the control of the cell cycle
Q28546976The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway
Q92651386The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction
Q41453687The Neurospora crassa PP2A Regulatory Subunits RGB1 and B56 Are Required for Proper Growth and Development and Interact with the NDR Kinase COT1.
Q34707593The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells.
Q36229017The PP2A inhibitor SET regulates natural killer cell IFN-gamma production
Q83154823The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants
Q40095189The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration
Q35775532The Proteome Profiles of the Cerebellum of Juvenile, Adult and Aged Rats--An Ontogenetic Study.
Q24337165The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1
Q38618873The Role of Ceramide in the Pathogenesis of Alcoholic Liver Disease
Q89944283The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
Q30884268The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size.
Q27935515The Saccharomyces cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A.
Q35203598The Ser/Thr phosphatase PP2A regulatory subunit widerborst inhibits notch signaling
Q35956614The Small C-terminal Domain Phosphatase 1 Inhibits Cancer Cell Migration and Invasion by Dephosphorylating Ser(P)68-Twist1 to Accelerate Twist1 Protein Degradation
Q41859703The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Q34470987The Zds proteins control entry into mitosis and target protein phosphatase 2A to the Cdc25 phosphatase
Q37333718The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.
Q28570863The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells
Q26824764The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity
Q101237515The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction
Q37048453The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway
Q46291674The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.
Q39774265The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
Q53344894The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.
Q24318638The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase
Q35015930The effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin
Q36050987The emerging role of the PI3-K-Akt pathway in prostate cancer progression
Q40680194The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit
Q38319012The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function
Q39798753The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication
Q64261612The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver
Q38813273The neglected messengers: Control of cardiac myofilaments by protein phosphatases.
Q24646616The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
Q36449154The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3
Q28214238The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status
Q37834642The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins
Q43628470The predicted beta12-beta13 loop is important for inhibition of PP2Acalpha by the antitumor drug fostriecin
Q90290783The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer
Q95326058The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα-SOD2 pathway
Q39886482The protein phosphatase 2A regulatory subunit B56γ mediates suppression of T cell receptor (TCR)-induced nuclear factor-κB (NF-κB) activity
Q28573860The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation
Q38090432The regulatory roles of phosphatases in cancer
Q27003263The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases
Q36180733The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling
Q37406716The role of PP2A A subunits in tumor suppression
Q33842870The role of SET/I2PP2A in canine mammary tumors.
Q34468774The role of adenovirus E4orf4 protein in viral replication and cell killing
Q28256247The role of mTOR signaling in Alzheimer disease
Q35128680The role of serine/threonine protein phosphatases in exocytosis
Q37832908The role of shugoshin in meiotic chromosome segregation
Q46736518The secondary structure of calcineurin regulatory region and conformational change induced by calcium/calmodulin binding
Q38506608The secreted proteome profile of developing Dictyostelium discoideum cells
Q50875190The serine/threonine protein phosphatase 2A controls autoimmunity.
Q28581352The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission
Q27666843The structural basis for tight control of PP2A methylation and function by LCMT-1.
Q24307546The tumor suppressor PP2A Abeta regulates the RalA GTPase
Q47137224The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model
Q37600516The ubiquitin-proteasome pathway and endothelial (dys)function
Q35037262Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia
Q28583084Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor
Q64776549To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling
Q28593741Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1
Q28749743Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell
Q48117016Transgenic and knockout models of PP2A.
Q34768889Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility
Q39884396Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia.
Q33876600Treatment of cardiovascular disease by traditional Chinese medicine against pregnane X receptor
Q33786655Treatment of rheumatoid arthritis with traditional chinese medicine.
Q40134384Truncated form of the Epstein-Barr virus protein EBNA-LP protects against caspase-dependent apoptosis by inhibiting protein phosphatase 2A.
Q37082620Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells
Q24796679Tumor cell-collagen interactions: Identification and semi-quantitative evaluation of selectively-expressed genes by combination of differential display- and multiplex-PCR
Q42125094Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal
Q34115132Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.
Q39619527Two genes encoding protein phosphatase 2A catalytic subunits are differentially expressed in rice
Q39951396Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling.
Q43962307Tyrosine hydroxylase dephosphorylation by protein phosphatase 2A in bovine adrenal chromaffin cells
Q24811827Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction
Q28570987Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A
Q28189055Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
Q37201381Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling
Q35083891Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease
Q47606567Upregulated osterix expression elicited by Runx2 and Dlx5 is required for the accelerated osteoblast differentiation in PP2A Cα-knockdown cells
Q39565343Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen
Q27472766Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.
Q40425153Use of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicals
Q90103104Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function
Q79365408Validation of interactions with protein phosphatase-1
Q35146774Viewing serine/threonine protein phosphatases through the eyes of drug designers
Q28240818Viral infections and cell cycle G2/M regulation
Q28542846Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells
Q40690657Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia
Q35004570Whole genome sequencing identifies a deletion in protein phosphatase 2A that affects its stability and localization in Chlamydomonas reinhardtii
Q30366739XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding.
Q30421808Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex
Q30584884Xiao Yao San Improves Depressive-Like Behavior in Rats through Modulation of β-Arrestin 2-Mediated Pathways in Hippocampus
Q27939447Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment
Q92919406Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12
Q38889604Zinc binds to and directly inhibits protein phosphatase 2A in vitro
Q58542293cAMP regulation of protein phosphatases PP1 and PP2A in brain
Q46712109discordia1 and alternative discordia1 function redundantly at the cortical division site to promote preprophase band formation and orient division planes in maize
Q40383681mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
Q38554814miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells
Q37735611miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma
Q36869603p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility
Q39216523p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis
Q51761646α4 coordinates small intestinal epithelium homeostasis by regulating stability of HuR.
Q39588362α4 is highly expressed in carcinogen-transformed human cells and primary human cancers

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